CYP2C9 Cancer Research Results

CYP2C9, CYP2C9: Click to Expand ⟱
Source:
Type:
CYP2C9, cytochrome P450 enzyme
– CYP2C9 is involved in the metabolism of a range of xenobiotics, including several anticancer drugs, which can affect drug efficacy and toxicity.
– Although CYP2C9 is not traditionally considered an oncogene or tumor suppressor, its expression and genetic variants can influence patient responses to chemotherapy.
Scientific Papers found: Click to Expand⟱
1152- Api,    Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
- Analysis, Nor, NA
*BioAv↓, Half-Life∅, *BioAv↓, Dose∅, Synergy↑, CYP1A2↓, CYP2C9↓, CYP3A4↓,
5480- BM,    Inhibition of Human Cytochrome P450 Enzymes by Bacopa monnieri Standardized Extract and Constituents
- Human, Nor, NA
P450↓, CYP3A4↓, CYP2C9↓,
6137- CHr,    Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters
- in-vitro, Var, NA
CYP2C9↓, OATPs↓, ABCG2↓, BioEnh↝,
7769- IBC,    Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters
- in-vivo, Var, NA
*AntiCan↑, *AntiAg↑, *AntiFungal↑, CYP2C9↓, UGT1A↓, CYP2D6↓, CYP2E1↓,
8217- LCA,    Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice
- Study, Nor, NA
*CYP1A1↓, *CYP2C19↓, *CYP2C8↓, *CYP2C9↓, *CYP3A4↓, *CYP2E1↓, *CYP2D6↓, *BioEnh↑, eff↑,
9279- SES, SSM,    Sesamin exhibits potential food-drug interactions through the inhibition of cytochrome P450s and human UDP-glucuronosyltransferases in vitro
- Review, Var, NA
*Inflam↓, *antiOx↓, *hepatoP↓, *TC↓, *CYP2C9↓, *CYP2C19↓, *other↝,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Barriers & Transport(tgid=15) ⓘ

OATPs↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioEnh↝, 1,   CYP1A2↓, 1,   CYP2C9↓, 4,   CYP2D6↓, 1,   CYP2E1↓, 1,   CYP3A4↓, 2,   Dose∅, 1,   eff↑, 1,   Half-Life∅, 1,   P450↓, 1,   Synergy↑, 1,   UGT1A↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioEnh↑, 1,   CYP1A1↓, 1,   CYP2C19↓, 2,   CYP2C8↓, 1,   CYP2C9↓, 2,   CYP2D6↓, 1,   CYP2E1↓, 1,   CYP3A4↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

TC↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   hepatoP↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,  
Total Targets: 17

Scientific Paper Hit Count for: CYP2C9, CYP2C9
1 Apigenin (mainly Parsley)
1 Bacopa monnieri
1 Chrysin
1 Isobavachalcone
1 Licochalcone A
1 Sesamin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1130  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page