CYP3A4 Cancer Research Results

CYP3A4, CYP3A4: Click to Expand ⟱
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Type:
CYP3A4 is the most abundant cytochrome P450 enzyme in the liver and is also expressed in extrahepatic tissues.
– It metabolizes a wide range of drugs and endogenous substrates, including hormones.

– In some studies, higher CYP3A4 expression has been correlated with poorer response to treatment and potentially worse survival.
Scientific Papers found: Click to Expand⟱
5442- AG,  Ome,    Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats
- in-vivo, Nor, NA
*other?, *P-gp/ABCB1↑, *CYP3A4↑,
1152- Api,    Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
- Analysis, Nor, NA
*BioAv↓, Half-Life∅, *BioAv↓, Dose∅, Synergy↑, CYP1A2↓, CYP2C9↓, CYP3A4↓,
5718- BF,    Bufalin inhibits CYP3A4 activity in vitro and in vivo
- in-vivo, Nor, NA
CYP3A4↓, Apoptosis↑, AntiTum↑,
5597- Bical,    Bicalutamide: clinical pharmacokinetics and metabolism
- Review, Pca, NA
Dose↝, BioAv↑, Half-Life↑, CYP3A4↓, PSA↓,
5480- BM,    Inhibition of Human Cytochrome P450 Enzymes by Bacopa monnieri Standardized Extract and Constituents
- Human, Nor, NA
P450↓, CYP3A4↓, CYP2C9↓,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp/ABCB1↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5714- Brut,    Probable Interaction of Bergamottin and Cyclosporine in a Lung Transplant Recipient
- Case Report, Nor, NA
*CYP3A4↓,
8849- DIM,  I3C,    Indoles Derived From Glucobrassicin: Cancer Chemoprevention by Indole-3-Carbinol and 3,3'-Diindolylmethane
- Review, Var, NA
DNMTs↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, chemoPv↑, AntiCan↑, CYP3A4↓, Dose↝, GutMicro↑, Synergy↑,
6603- Ech,  doxoR,    The effect of Echinacea purpurea on the pharmacokinetics of docetaxel
- Trial, Var, NA
other∅, other↝, Imm↑, CYP3A4⇅, other↑,
8589- FS,    Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
- Study, Var, NA
Risk↓, Ingr?, *antiOx?, *Inflam↓, *Estro↓, *Ingr↑, *neuroP↑, *Obesity↓, TumMeta↓, TumCP↓, *AntiAg↑, *AntiDiabetic↑, *ROS↓, *GutMicro↑, FOXM1↓, PCNA↓, Ki-67↓, CDK2↓, Akt↓, PDGF↓, ERK↓, p‑GSK‐3β↓, IGFR↓, p‑MDM2↓, EGFR↓, FASN↓, CYP3A4↓, COX2/PTGS2↓, Cyt‑c↑, cl‑PARP↑, Casp3↑, p‑P53↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, BRCA1↓, BRCA2↓, survivin↓, GADD45A↓, FAK↓, pax↓, Rho↓, Rac1↓, Cdc42↓, MMP2↓, TIMP1↑, TIMP2↑, angioG↓, MMP↓, ChemoSen↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
7751- ISL,  LE,    Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents
- in-vitro, Nor, NA
*CYP2C6↓, *CYP3A4↓, *P450↓, *other↑,
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
8252- LCA,    Effects of licochalcone A on the bioavailability and pharmacokinetics of nifedipine in rats: possible role of intestinal CYP3A4 and P-gp inhibition by licochalcone A.
- in-vivo, Nor, NA
*CYP3A4↓, *P-gp/ABCB1↓,
8216- LCA,    Effects of licochalcone A on the bioavailability and pharmacokinetics of nifedipine in rats: possible role of intestinal CYP3A4 and P-gp inhibition by licochalcone A
- in-vivo, Nor, NA
*Dose↝, *CYP3A4↓, *P-gp/ABCB1↓,
8217- LCA,    Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice
- Study, Nor, NA
*CYP1A1↓, *CYP2C19↓, *CYP2C8↓, *CYP2C9↓, *CYP3A4↓, *CYP2E1↓, *CYP2D6↓, *BioEnh↑, eff↑,
8190- LGE,  doxoR,    Cymbopogon citratus and Citral Overcome Doxorubicin Resistance in Cancer Cells via Modulating the Drug's Metabolism, Toxicity, and Multidrug Transporters
- in-vitro, BC, MCF7 - in-vitro, Liver, HepG2 - in-vitro, Ovarian, SKOV3
ChemoSen↑, CYP3A4↓, PXR, NR1I2↓, GSTA1↓, MDR1↓, MRP1/ABCC1↓, ABCG2↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
1722- SFN,    Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems
- Review, Var, NA
TumCCA↑, CYP1A1↓, CYP3A4↓, Cyt‑c↑, Casp9↑, Apoptosis↑, ROS↑, MAPK↑, P53↑, BAX↑, ChemoSen↑, HDAC↓, GSH↓, HO-1↑,

Showing Research Papers: 1 to 19 of 19

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 19

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ARE↑, 1,   GPx4↓, 1,   GSH↓, 3,   HO-1↓, 1,   HO-1↑, 2,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 5,   Trx↑, 1,   TrxR↑, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   compIII↓, 1,   ETC↓, 1,   OCR↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 1,   FASN↓, 1,   Glycolysis↓, 1,   p‑GSK‐3β↓, 1,   PDK1 / PDPK1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 5,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   BIM↑, 1,   Casp↑, 2,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 4,   Fas↑, 1,   Ferroptosis↑, 1,   p‑MDM2↓, 1,   MOMP↑, 1,   p38↓, 1,   survivin↓, 2,   TumCD↑, 1,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   EGFR↓, 3,   ERK↓, 2,   HER2/EBBR2↓, 2,   IGFR↓, 1,   MAPK↑, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DNMTs↓, 1,   FOXM1↓, 1,   FOXO1↓, 1,   FOXO3↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   OCT4↓, 1,   other↑, 1,   other↝, 2,   other∅, 1,   SOX2↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   BRCA2↓, 1,   DNAdam↑, 1,   P53↑, 2,   p‑P53↑, 1,   cl‑PARP↑, 2,   PCNA↓, 1,   Telomerase↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   GADD45A↓, 1,   Ki-67↓, 1,   P21↑, 1,   p27/CDKN1B↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   Ki-67↓, 1,   Nanog↓, 1,   NOTCH2↑, 1,   TumCG↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Cdc42↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   FAK↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   MMP2↓, 3,   MMP9↓, 1,   MMPs↓, 1,   pax↓, 1,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 1,   Snail↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 2,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   CD31/PECAM-1↓, 1,   Hif1a↓, 2,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   DR4↑, 1,   Imm↑, 2,   NF-kB↓, 2,   PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PXR, NR1I2↓, 1,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 7,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2C9↓, 2,   CYP2E1↑, 1,   CYP3A4↓, 11,   CYP3A4⇅, 1,   Dose↓, 1,   Dose↝, 5,   Dose∅, 1,   eff↑, 1,   GSTA1↓, 1,   Half-Life↑, 1,   Half-Life∅, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P450↓, 3,   RadioS↑, 2,   selectivity↑, 2,   selectivity↝, 1,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↓, 1,   EGFR↓, 3,   FOXM1↓, 1,   HER2/EBBR2↓, 2,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 2,   Risk↓, 3,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,  
Total Targets: 161

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↑, 1,   GPx1↑, 1,   ROS↓, 3,   SOD1↑, 1,   SOD2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,   other↑, 1,   other↝, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Estro↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioEnh↑, 2,   CYP1A1↓, 1,   CYP2C19↓, 1,   CYP2C6↓, 1,   CYP2C8↓, 1,   CYP2C9↓, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   CYP3A4↓, 6,   CYP3A4↑, 1,   Dose↝, 3,   eff↑, 2,   Half-Life↝, 2,   P-gp/ABCB1↓, 3,   P-gp/ABCB1↑, 1,   P450↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   neuroP↑, 3,   Obesity↓, 1,   toxicity↑, 1,   toxicity↝, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,  
Total Targets: 39

Scientific Paper Hit Count for: CYP3A4, CYP3A4
3 Licochalcone A
2 doxorubicin
2 Phenethyl isothiocyanate
2 Sulforaphane (mainly Broccoli)
1 Astragalus
1 Omeprazole
1 Apigenin (mainly Parsley)
1 Bufalin/Huachansu
1 Bicalutamide
1 Bacopa monnieri
1 borneol
1 Bruteridin(bergamot juice)
1 Diindolylmethane
1 Indole-3-carbinol
1 Echinacea
1 Flaxseed/Linseed
1 Ginkgetin
1 Isoliquiritigenin
1 Licorice
1 Isothiocyanates
1 Allyl isothiocyanate
1 Benzyl isothiocyanate
1 Lemongrass Extract/Citral
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1131  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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