hyperG Cancer Research Results

hyperG, hyperglycemia: Click to Expand ⟱
Source:
Type:
Hyperglycemia is defined as elevated blood glucose levels and may result from diabetes mellitus, insulin resistance, or stress-induced metabolic changes.

– Elevated glucose levels provide abundant energy resources, potentially facilitating rapid tumor cell division and growth.
– Some cancers upregulate glucose transporters (such as GLUT1) to utilize the increased availability of glucose.

Oxidative Stress and DNA Damage:
– Hyperglycemia is associated with the production of reactive oxygen species (ROS) and advanced glycation end-products (AGEs).
– Both ROS and AGEs can lead to DNA damage, genomic instability, and alterations in cell signaling pathways that promote tumor progression.

– Studies have linked hyperglycemia with increased tumor aggressiveness in several cancer types, including breast, colorectal, and pancreatic cancers.
– Patients with hyperglycemia may experience more rapid disease progression and a higher likelihood of metastasis.
– In some cases, elevated glucose levels have been associated with chemotherapy resistance and decreased sensitivity to radiation therapy.

– Effective control of blood sugar through dietary interventions, medications (e.g., insulin, metformin), and lifestyle modifications may beneficially impact cancer outcomes.
– Regular monitoring of blood glucose and hemoglobin A1c (HbA1c) can inform oncologists about potential metabolic challenges during cancer treatment.
Scientific Papers found: Click to Expand⟱
9141- CC,    Camu Camu (Myrciaria dubia (Kunth) McVaugh): An Amazonian Fruit with Biofunctional Properties–A Review
- Review, Nor, NA
*Ingr↝, *antiOx↑, *hyperG↓, *Obesity↓, *QoL↓, *AntiBio↑, *Inflam↓, *TumCP↓, *hepatoP↑, *Ingr↝, *eff↝, *antiAll↑, *AntiTum↑, *NRF2↑, *NQO1↑, *NA↑,
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, Synergy↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, Synergy↑,
7824- MBS,  IVT,  VT,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *ROS↓, *Inflam↓, *AChE↓, *BBB↑, *memory↑, *hepatoP↑, *Imm↑, *hyperG↓, *AntiCan↑, *eff↑, *Stroke↓, *BACE/β-secretase↓, *PI3K↓, *Akt↓, *mTOR↓, *Dose↓,
8960- mushLions,    Recent Advances in Erinacine A: Preparation, Biological Activities, and Biosynthetic Pathway
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *NGF↑, *other↝, *antiOx↑, *Inflam↓, *antiCG↑, *Bacteria↓, *hyperG↝, *AntiDiabetic↑, *AntiCan↑, *neuroG↑, *cognitive↑, *Stroke↓, *IL1β↓, *IL6↓, *TNF-α↓, *RNS↓, *iNOS↓, *MAPK↓, *CHOP/DDIT3↓, TumCD↓, ROS↑, TumCP↓, TumCI↓, ROCK1↓, LIMK2↓, Cofilin↓, PI3K↓, mTOR↓, P70S6K↓, TumCMig↓, TumMeta↓, TGF-β↓, MMP9↓, *AntiAge↑, *RIP1↓, *cl‑Casp8↓, *cl‑Casp3↓, *NRF2↑, *HO-1↑, *SOD1↑,
1681- PBG,    Propolis: Its Role and Efficacy in Human Health and Diseases
- Review, Nor, NA
*Inflam↓, *AntiCan↑, *antiOx↑, *hyperG↓, *BG↓, *HbA1c↓, *NF-kB↓, *ROS↓, *TGF-β↑, *selectivity↑,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

hyperG↓, 1,   ROS↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑GSK‐3β↑, 1,  

Cell Death(tgid=5) ⓘ

ASK1↑, 1,   BIM↑, 1,   Casp3↑, 1,   TumCD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   mTOR↓, 1,   mTOR↑, 2,   P70S6K↓, 1,   PI3K↓, 1,   PI3K↑, 2,   PKA↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

KLF2↓, 1,   KLF5↓, 1,   OCT4↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK4↑, 2,   CDK6↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Nanog↓, 1,   TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

Cofilin↓, 1,   LIMK2↓, 1,   MMP9↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,   eff∅, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 36

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   HO-1↑, 1,   hyperG↓, 3,   hyperG↝, 1,   NQO1↑, 1,   NRF2↑, 2,   RNS↓, 1,   ROS↓, 2,   SOD1↑, 1,  

Cell Death(tgid=5) ⓘ

cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   MAPK↓, 1,   mTOR↓, 1,   PI3K↓, 1,   RIP1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

TGF-β↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 4,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↓, 1,   eff↑, 1,   eff↝, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   HbA1c↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 1,   AntiCan↑, 3,   antiCG↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 2,   Obesity↓, 1,   QoL↓, 1,   Stroke↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   Bacteria↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 58

Scientific Paper Hit Count for: hyperG, hyperglycemia
1 Camu camu
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Mung Bean Sprouts
1 Isovitexin
1 Vitexin
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Propolis -bee glue
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1167  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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