hepatoP Cancer Research Results

hepatoP, L,hepatoprotective: Click to Expand ⟱
Source:
Type:
Hepatoprotective is the ability of a chemical substance to prevent damage to the liver.

Grapefruit:
-hepatoprotective potential has emerged from the study of naringenin and naringin.
Blueberries/cranberries:
-proanthocyanidins
Grape:
Nopal (Cactus pear) and tuna (Cactus pear fruit) “Opuntia ficus-indica”:
Chamomile (Matricaria chamomilla or Chamomilla recutita):
Silymarin (Silybum marianum):
Blue green algae spirulina :
Propolis (bee glue):

POLYSACCHARIDES
β-glucans
Scientific Papers found: Click to Expand⟱
6477- 1,8-Cin,    Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling
- in-vivo, Nor, NA
*MDA↓, *GSH↑, *GPx↑, *Inflam↓, *TLR4↓, *MyD88↓, *NF-kB↓, *AST↓, *ALAT↓, *hepatoP↑, *ROS↓,
5428- AG,    Meta-Analysis of Astragalus-Containing Traditional Chinese Medicine Combined With Chemotherapy for Colorectal Cancer: Efficacy and Safety to Tumor Response
- Review, CRC, NA
ChemoSen↑, chemoP↑, QoL↑, RenoP∅, hepatoP∅,
4395- AgNPs,    Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata
- in-vivo, LiverDam, NA
*hepatoP↑, *LDH↓,
4390- AgNPs,    Therapeutic Potential of Cucumis melo (L.) Fruit Extract and Its Silver Nanopartciles Against DEN-Induced Hepatocellular Cancer in Rats
- in-vivo, Liver, NA
hepatoP↑, AST↓, ALAT↓, ALP↓,
4387- AgNPs,    Attenuation of diethylnitrosamine (DEN) - Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles
- in-vitro, Liver, NA
IL6↓, TNF-α↓, IL1β↓, hepatoP↑,
4386- AgNPs,    Evaluation of hepatic cancer stem cells (CD73+, CD44+, and CD90+) induced by diethylnitrosamine in male rats and treatment with biologically synthesized silver nanoparticles
- in-vitro, Var, NA
hepatoP↑, CD44↓, CSCs↓,
4385- AgNPs,    Hepatoprotective effect of engineered silver nanoparticles coated bioactive compounds against diethylnitrosamine induced hepatocarcinogenesis in experimental mice
- in-vitro, Liver, NA
hepatoP↑, *AST↓, *ALAT↓, *Catalase↑, *GPx↑, *GSTA1↑, *SOD↑,
4361- AgNPs,  GoldNP,    Biocompatible silver, gold and silver/gold alloy nanoparticles for enhanced cancer therapy: in vitro and in vivo perspectives
- in-vivo, Liver, HepG2
TumCD↑, TumVol↓, *toxicity↝, hepatoP↑,
2207- AgNPs,  TQ,    Protective effects of Nigella sativa L. seeds aqueous extract-based silver nanoparticles on sepsis-induced damages in rats
- in-vivo, Nor, NA
*eff↑, *RenoP↑, *hepatoP↑, *MDA↓, *SOD↑, *GSH↑, *TNF-α↓, *IL1β↓,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
2205- AgNPs,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
5355- AL,    Mini-review: The health benefits and applications of allicin
- Review, Var, NA
*BioAv↑, *cardioP↑, *hepatoP↑, *RenoP↑, *Half-Life↝, *BioAv↓, *neuroP↑, *cognitive↑, *ROS↓, *lipid-P↓, *DNArepair↑, *ChemoSen↑,
2658- AL,    The Toxic Effect Ways of Allicin on Different Cell Lines
- Review, Var, NA
*antiOx↑, *AntiAg↑, *cardioP↑, Ca+2↑, ROS↑, Casp↑, p38↑, MAPK↑, hepatoP↑, chemoP↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
2667- AL,    Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment
- Review, GC, NA
AntiCan↑, ChemoSen↑, angioG↓, chemoP↑, *GutMicro↑, *antiOx↑, other↝, GSH↓, Thiols↓, *ROS↓, *hepatoP↑, *Inflam↓, *NF-kB↓,
6763- AL,    Revealing the Therapeutic Uses of Garlic (Allium sativum) and Its Potential for Drug Discovery
- Review, Nor, NA
*Inflam↓, *AntiBio↑, *AntiDiabetic↑, *hepatoP↑, *antiOx↑, *AntiFungal↑, *Wound Healing↑, *other↑, *BP↓, *LDL↓, *AntiAg↑, *cognitive↑, *memory↑, Risk↑, *COX1↓, *TXA2↓, *antiAll↑,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3446- ALA,  CUR,    The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression
- in-vivo, Nor, NA
*hepatoP↑, *α-SMA↓, *COL3A1↓, *ROS↓, *GSH↑, *ALAT↓, *AST↓, *ALP↓, *MDA↓,
7398- Amla,    Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis
- in-vivo, Nor, NA
*hepatoP↑,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
7403- Amla,    Aqueous Extract of Emblica officinalis Linn (Indian gooseberry) in Combination with Iodine is More Efficacious than Iodine Alone in Mitigating Mucositis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: Retrospective Observations
- Trial, HNSCC, NA
Mucositis↓, Dose↝, Dose↝, *Bacteria↓, *AntiFungal↑, *AntiViral↑, *hepatoP↑, *RenoP↑, *neuroP↑, Dose↝,
7400- Amla,    Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer
- Review, Var, NA
radioP↑, ChemoSen↑, chemoPv↑, *ROS↓, antiOx↑, Inflam↓, Imm↑, *hepatoP↑, *cardioP↑, *lipid-P↓, TumCCA↑, Chk2↑, CDK1↓, CycB/CCNB1↓, CDC25↓, TumMeta↓,
7839- AO,  ISQ,    The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model
- in-vivo, AD, NA - in-vivo, Obesity, NA
*Dose↝, *Obesity↓, *Leptin↓, *adiP↑, *hepatoP↑, *PSEN1/PS1↓, *PSEN2/PS-2↓, *BACE/β-secretase↓, *Synergy↑,
2636- Api,    Apigenin unveiled: an encyclopedic review of its preclinical and clinical insights
- Review, Nor, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *Inflam↓, *antiOx↑, *hepatoP↑, ChemoSen↑,
2317- Api,    Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1α mediated oxidative stress
- in-vivo, Nor, NA
*hepatoP↑, *PKM2↓, *Hif1a↓, *MDA↓, *Catalase↓, *GSH↑, *SOD↑, *GPx↑, *TAC↑, *α-SMA↓, *Vim↓, *ROS↓,
2571- ART/DHA,    Cancer combination therapies with artemisinin-type drugs
- Review, Var, NA
AntiTum↑, ChemoSen↑, hepatoP↝,
5394- Ash,    Safety and pharmacokinetics of Withaferin-A in advanced stage high grade osteosarcoma: A phase I trial
- Trial, OS, NA
toxicity↝, hepatoP↓, BioAv↓, Apoptosis↑, ROS↑, TumCCA↑,
3174- Ash,    Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
NF-kB↓, angioG↓, Inflam↓, TumCP↓, TumCMig↓, TumCI↓, Sp1/3/4↓, VEGF↓, angioG↓, uPA↓, PDGF↓, MCP1/CCL2↓, ICAM-1↓, *NRF2↑, *hepatoP↑,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP/DDIT3↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3164- Ash,    Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
- in-vitro, Nor, NA
*hepatoP↑, *IKKα↓, *NLRP3↓, *NRF2↑, *AMPK↑, *Inflam↓, *Apoptosis↓, *cl‑Casp3↓, *cl‑PARP1↓, *NLRP3↓, *ROS↓, *ALAT↓, *AST↓, *GSH↑,
3170- Ash,    Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms
- in-vitro, Nor, NRK52E - in-vivo, NA, NA
*RenoP↑, *hepatoP↑, *creat↓, *BUN↓, *uricA↓, *Apoptosis↓, *α-SMA↓,
5384- AsP,  MLT,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
4814- ASTX,    Chemopreventive and therapeutic efficacy of astaxanthin against cancer: A comprehensive review
- Review, Var, NA
Apoptosis↑, EMT↓, AntiCan↑, *cardioP↑, *neuroP↑, TumCG↓, *antiOx↑, *Bacteria↓, *Imm↑, *hepatoP↑, *AntiDiabetic↑, ROS↓, *chemoPv↑,
5506- Ba,    Improved Bioavailability and Hepatoprotective Activity of Baicalein Via a Self-assembled Solutol HS15 Micelles System
- in-vivo, Nor, NA
*AST↓, *ALAT↓, *GSH↓, *SOD↓, *MDA↓, *hepatoP↑, *Inflam↓, BioAv↑,
5502- Ba,    An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways
- Review, Var, NA
*AntiCan↑, *antiOx↑, *hepatoP↑, *neuroP↑, *ROS↓, Ca+2↑, ROS↑, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, MMP↓, Mcl-1↓, PI3K↓, Akt↓, mTOR↓, BAD↓, ERK↓, MEK↓, DR5↑, Fas↑, TumMeta↓, EMT↓, SMAD4↓, TGF-β↓, MMP9↓, MMP2↓, HIF-1↓, 12LOX↓,
5248- Ba,  BA,  doxoR,    Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, Nor, HUVECs
toxicity↝, ChemoSen↑, selectivity↑, Apoptosis↑, necrosis↑, MMP↓, DNAdam↑, cl‑PARP↑, MRP1/ABCC1↓, Bcl-2↓, hepatoP↑, cardioP↑, BioAv↝,
2610- Ba,    Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice
- in-vivo, Nor, NA
*TNF-α↑, *IL6↑, *hepatoP↑,
2609- Ba,    Baicalein: unveiling the multifaceted marvel of hepatoprotection and beyond
- Review, Nor, NA
*hepatoP↑, *neuroP↑, *Inflam↓,
2607- Ba,  SIL,    Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2
- in-vivo, Nor, NA
*BioEnh↑, *hepatoP↑, *antiOx↑, *Inflam↓,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2614- Ba,    Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders
- Review, Nor, NA
*toxicity↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *MCP1/CCL2↓, *hepatoP↑, *neuroP↑, *antiAll↑,
2613- Ba,    Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *SOD↑, *Catalase↑, *GSH↑, *MAPK↓, *p‑JAK2↓, *p‑STAT3↓, *ALAT↓, *AST↓, *ROS↓, *antiOx↑,
2675- BBR,    The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress
- Review, Var, NA
*Inflam↓, *antiOx↑, *ER Stress↓, *cardioP↑, *RenoP↑, *hepatoP↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
4275- BBR,    Pharmacological effects of berberine on mood disorders
- Review, AD, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *eff↑, *5HT↑, *Mood↑, *BDNF↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
2718- BetA,    The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis
- in-vitro, AML, U937
TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1/CCL2↓, MMP9↓, COX2/PTGS2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
5474- BM,    Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
- Review, Var, NA
*memory↑, *neuroP↑, *cognitive↑, *hepatoP↑, *antiOx↑, *AntiDiabetic↑, *fatigue↓, *GSK‐3β↓, *PI3K↑, *Akt↑, *tau↓, *ROS↓, *Inflam↓,

Showing Research Papers: 1 to 50 of 321
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 321

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↓, 3,   Catalase↑, 3,   GPx↑, 3,   GPx4↓, 2,   GSH↓, 13,   GSH↑, 5,   GSR↑, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 8,   Iron↑, 2,   lipid-P↓, 4,   lipid-P↑, 4,   MDA↓, 2,   MDA↑, 3,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 3,   NRF2↑, 8,   Prx↓, 1,   PrxII↓, 1,   ROS↓, 13,   ROS↑, 63,   ROS⇅, 1,   ROS↝, 3,   i-ROS↑, 2,   mt-ROS↑, 2,   SOD?, 1,   SOD↓, 3,   SOD↑, 4,   SOD1↑, 2,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   Trx↓, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 1,   CDC25↓, 2,   compI↓, 2,   compII↓, 1,   ETC↓, 2,   mitResp↓, 1,   mtDam↑, 5,   OXPHOS↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ALAT↓, 13,   AMP↑, 1,   AMPK↑, 4,   ATP↓, 10,   ATP↑, 1,   mt-ATP↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 4,   GlutMet↓, 1,   Glycolysis↓, 11,   GSK‐3β↓, 3,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 1,   HK2↓, 7,   lactateProd↓, 5,   LDHA↓, 2,   PCK1↓, 1,   PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PKM2↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   TCA↓, 2,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 2,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 61,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAD↑, 3,   Bak↑, 4,   BAX↓, 1,   BAX↑, 40,   Bax:Bcl2↑, 9,   Bcl-2↓, 38,   Bcl-2↑, 2,   Bcl-xL↓, 10,   Bcl-xL↑, 1,   BIM↓, 1,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 10,   Casp1↑, 1,   Casp12↑, 1,   Casp3↑, 40,   cl‑Casp3↑, 3,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 15,   Casp9↓, 1,   Casp9↑, 27,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 25,   Diablo↑, 1,   DR5↑, 6,   FADD↑, 3,   Fas↑, 7,   FasL↑, 2,   Ferroptosis↑, 2,   GranB/GZMB↝, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 3,   iNOS↓, 4,   Mcl-1↓, 5,   MDM2↓, 2,   MDM2↑, 1,   MOMP↑, 2,   necrosis↑, 1,   p38↓, 1,   p38↑, 9,   p‑p38↓, 2,   p‑p38↑, 2,   Perforin↝, 1,   PUMA↑, 1,   survivin↓, 13,   TRAIL↑, 1,   TumCD↓, 1,   TumCD↑, 4,   XIAP↓, 9,   XIAP↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 40,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 5,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 1,   EGFR↓, 10,   ERK↓, 21,   ERK↑, 2,   p‑ERK↓, 3,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   Hippo↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   JAK1↓, 2,   JAK2↓, 6,   JNK↓, 3,   JNK↑, 4,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 12,   MAPK↑, 6,   p‑MAPK↑, 1,   MEK↓, 2,   mTOR↓, 21,   p‑mTOR↓, 1,   mTORC2↓, 1,   p42↑, 1,   P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 33,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 2,   PTEN↓, 1,   PTEN↑, 7,   Raf↓, 1,   RAS↓, 2,   RAS↑, 1,   RET↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 4,   STAT3↓, 27,   STAT3↑, 2,   p‑STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 2,   ChrMod↑, 1,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 17,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 2,   EZH2↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   p‑FOXO3↓, 1,   p‑H3↓, 1,   HATs↑, 2,   HDAC↓, 8,   HDAC1↓, 3,   HDAC2↓, 3,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-203↑, 1,   miR-34a↓, 2,   miR-34a↑, 1,   MYCN↓, 1,   NDRG1↑, 1,   OCT4↓, 3,   other↑, 2,   other↝, 4,   PhotoS↑, 2,   sonoS↑, 1,   SOX2↓, 4,   tumCV?, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 8,   GRP78/BiP↑, 1,   GRP78/BiP↝, 1,   HSP90↓, 3,   NQO2↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↑, 6,   LC3II↑, 3,   LC3s↑, 1,   p62↓, 2,   TumAuto↑, 12,   VMP-1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   DNAdam↑, 14,   hTERT/TERT↓, 2,   P53↓, 2,   P53↑, 24,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 4,   cl‑PARP↓, 1,   cl‑PARP↑, 12,   PCNA↓, 13,   Telomerase↓, 2,   TOP1↓, 2,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 5,   CDK1↑, 2,   CDK2↓, 9,   CDK4↓, 12,   CDK4↑, 1,   CDK6↓, 3,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↑, 2,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 10,   cycD1/CCND1↓, 23,   cycE/CCNE↓, 3,   cycE/CCNE↑, 1,   GADD45A↑, 1,   Ki-67↓, 11,   mitA↑, 1,   P21↑, 20,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 6,   pRB↓, 1,   p‑pRB↓, 1,   RB1↓, 1,   RB1↑, 1,   TumCCA↑, 61,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 1,   cFos↓, 3,   CSCs?, 1,   CSCs↓, 9,   Diff↑, 1,   Gli↓, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   Ki-67↓, 11,   Let-7↑, 1,   mTORC1↓, 2,   Nanog↓, 3,   Nestin↓, 1,   NOTCH↓, 7,   NOTCH↑, 1,   NOTCH1↓, 3,   NOTCH1↑, 3,   Shh↓, 3,   Smo↓, 1,   TumCG↓, 26,   TumCP↓, 44,   Wnt↓, 13,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   BACH1↓, 1,   CA↓, 1,   Ca+2↑, 9,   i-Ca+2↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 9,   EMT↓, 21,   EMT↝, 1,   FAK↓, 4,   FAK↑, 1,   p‑FAK↓, 2,   Fibronectin↓, 1,   LAMs↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 21,   MMP2↑, 1,   MMP7↓, 2,   MMP9↓, 26,   MMP9↑, 2,   MMPs↓, 14,   MTA1↓, 1,   MUC4↓, 3,   N-cadherin↓, 5,   p44↑, 1,   PDGF↓, 3,   Rho↓, 2,   Rho↝, 1,   ROCK1↓, 1,   Slug↓, 2,   Smad1↑, 1,   SMAD4↓, 1,   Snail↓, 2,   TET1↑, 2,   TGF-β↓, 5,   TIMP1↑, 3,   TIMP2↓, 1,   TIMP2↑, 4,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 20,   TumCMig↓, 24,   TumMeta↓, 27,   TumMeta↑, 2,   Twist↓, 7,   uPA↓, 8,   Vim↓, 4,   Zeb1↓, 3,   ZEB2↓, 1,   β-catenin/ZEB1↓, 15,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 32,   angioG↑, 1,   CD31/PECAM-1↓, 1,   HIF-1↓, 2,   HIF-1↑, 1,   Hif1a↓, 20,   Hif1a↝, 1,   LOX1↓, 1,   TBXAS1/TxAS↓, 1,   VEGF↓, 29,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   GLUT1↓, 4,   GLUT4↓, 1,   MMP↓, 27,   NHE1↓, 1,   TRPM7↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 4,   CD47↓, 1,   CD8+↑, 3,   COX1↓, 1,   COX2/PTGS2↓, 22,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR4↓, 6,   DCells↑, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 2,   IL6↓, 17,   IL8↓, 4,   Imm↑, 6,   Imm↝, 2,   INF-γ↝, 1,   Inflam↓, 21,   Inflam↝, 1,   MCP1/CCL2↓, 2,   MDSCs↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 45,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 2,   NLRP3↑, 1,   PD-1↓, 1,   PD-L1↓, 5,   PGE2↓, 7,   PSA↓, 2,   T-Cell↑, 1,   TLR4↓, 1,   TNF-α↓, 16,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   ER(estro)↓, 2,   ERα/ESR1↓, 1,   PPARγ↓, 2,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 14,   BioAv↑, 17,   BioAv↝, 5,   BioEnh?, 1,   CBR1↓, 1,   ChemoSen↓, 1,   ChemoSen↑, 59,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   Dose?, 1,   Dose↝, 26,   eff↓, 2,   eff↑, 18,   eff↝, 6,   eff∅, 1,   Half-Life↓, 4,   Half-Life↝, 3,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   NAT↓, 1,   P-gp/ABCB1↓, 5,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 12,   selectivity↑, 21,   selectivity∅, 1,   Synergy↑, 35,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   AFP↑, 1,   ALAT↓, 13,   ALB↑, 1,   ALP↓, 3,   AR↓, 5,   AST?, 1,   AST↓, 9,   BP↓, 1,   BRCA1↓, 1,   BRCA1↑, 1,   BUN↓, 2,   creat↓, 3,   DBIL↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 10,   ERα/ESR1↓, 1,   EZH2↓, 2,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IBIL↓, 1,   IL6↓, 17,   Maspin↑, 1,   PC↑, 1,   PD-L1↓, 5,   PSA↓, 2,   RBC↑, 1,   TBIL↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 33,   AntiDiabetic↑, 1,   AntiTum↑, 9,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   cardioP↑, 16,   CardioT↑, 1,   chemoP↑, 32,   chemoPv↑, 9,   cognitive↑, 1,   hepatoP↓, 3,   hepatoP↑, 55,   hepatoP↝, 2,   hepatoP∅, 2,   Mucositis↓, 2,   neuroP↑, 11,   NP/CIPN↓, 3,   OS↓, 1,   OS↑, 6,   OS⇅, 1,   Pain↓, 3,   PFS↑, 1,   QoL↑, 4,   radioP↑, 8,   RenoP↑, 11,   RenoP∅, 1,   Risk↓, 4,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 11,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 1,   TumVol?, 1,   TumVol↓, 4,   TumW↓, 1,   Weight?, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 4,  
Total Targets: 555

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 9,   antiOx↑, 132,   ARE↑, 4,   Bil↓, 4,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 63,   DPPH↓, 1,   Fenton↓, 4,   GCLC↑, 2,   GCLC↝, 1,   GCLM↑, 2,   GCLM↝, 1,   GPx↓, 1,   GPx↑, 48,   GPx1↑, 1,   GPx4↓, 1,   GPx4↑, 1,   GSH↓, 3,   GSH↑, 82,   GSH/GSSG↑, 1,   GSR↑, 5,   GSSG↓, 2,   GSTs↓, 1,   GSTs↑, 14,   H2O2↓, 4,   HDL↓, 2,   HDL↑, 5,   HDL∅, 1,   HO-1?, 1,   HO-1↓, 3,   HO-1↑, 38,   HO-1⇅, 1,   hyperG↓, 1,   Iron↝, 1,   i-Iron↑, 1,   Keap1↓, 6,   Keap1↝, 2,   lipid-P?, 1,   lipid-P↓, 63,   lipid-P↑, 1,   MDA↓, 65,   MDA↑, 3,   MPO↓, 11,   NADH↓, 1,   NQO1↑, 9,   NQO1↝, 2,   NRF2?, 1,   NRF2↓, 3,   NRF2↑, 69,   RNS↓, 3,   ROS?, 2,   ROS↓, 171,   ROS↑, 7,   ROS⇅, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   selenoP↑, 1,   SOD↓, 3,   SOD↑, 89,   SOD1↑, 4,   SOD2↑, 2,   TAC↑, 5,   TBARS↓, 3,   Thiols↑, 2,   TOS↓, 1,   TOS↑, 1,   Trx↑, 2,   Trx1↑, 1,   uricA↓, 1,   VitC↑, 2,   VitE↑, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 7,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   compI↑, 1,   compII↑, 1,   compIII↓, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   ETC↓, 1,   Insulin↓, 2,   Insulin↑, 1,   MFN2↑, 1,   mtDam↓, 6,   PDH↑, 1,   PGC-1α↑, 5,   PGC-1α↝, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 3,   5LO↝, 1,   ACADS/SCAD↑, 1,   ACC↓, 2,   ACC↑, 1,   adiP↑, 1,   ALAT↓, 77,   ALAT↑, 4,   AMPK↓, 1,   AMPK↑, 20,   p‑AMPK↑, 2,   ATP↓, 2,   ATP↑, 6,   cAMP↑, 2,   CPT1A↑, 1,   CRM↑, 3,   CYP51/14LDM↑, 1,   FABP4↓, 1,   FAM↑, 1,   FASN↓, 2,   glucose↓, 10,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 2,   glyC↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 7,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 1,   H2S↑, 2,   HK2↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDL↓, 16,   lipidLev↓, 5,   NAD↓, 1,   NAD↑, 2,   NADPH↓, 4,   NADPH↑, 2,   NH3↓, 1,   PDKs↓, 1,   PFKP↓, 1,   PKM2↓, 2,   PLA2↓, 1,   SIRT1↑, 14,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 3,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 20,   ASC↓, 1,   BAX↓, 13,   Bax:Bcl2↓, 2,   Bcl-2↓, 3,   Bcl-2↑, 8,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 1,   Casp3↓, 22,   cl‑Casp3↓, 3,   proCasp3↓, 1,   Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 8,   Cyt‑c↓, 5,   Fas↓, 3,   Ferroptosis↓, 2,   Ferroptosis↑, 1,   GranB/GZMB↓, 1,   iNOS↓, 22,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 5,   p‑p38↓, 1,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 9,   p‑Akt↓, 1,   p‑Akt↑, 1,   Akt2↓, 1,   AMPKα↑, 1,   ERK↓, 4,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 3,   IKKα↑, 1,   p‑IKKα↓, 1,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 8,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 10,   MAPK↑, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   MEK↓, 1,   mTOR↓, 4,   mTOR↑, 4,   p‑mTOR↓, 1,   PDGFR-BB↓, 2,   PDGFRB↓, 1,   PI3K↓, 5,   PI3K↑, 6,   PKCδ↓, 1,   PP2A↑, 1,   PTEN↑, 1,   STAT↓, 2,   STAT3↓, 4,   STAT3↑, 1,   p‑STAT3↓, 1,   STAT5↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 7,   ATF2↑, 1,   ATF4↓, 3,   cJun↓, 1,   p‑cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   FOXO1↝, 1,   FOXO3↑, 1,   HDAC↑, 1,   miR-23a-3p↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↓, 3,   other↑, 6,   other↝, 11,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 6,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 9,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSPs↓, 1,   HSPs↑, 1,   IRE1↓, 1,   XBP-1↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 2,   LC3s↓, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 11,   DNArepair↑, 1,   P53↓, 4,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   Telomerase↓, 2,   TOP1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   GH↑, 1,   HH↓, 1,   IGF-1↓, 1,   Ki-67↓, 1,   neuroG↑, 3,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 12,   AP-1↓, 4,   BACH1↓, 1,   Ca+2↓, 7,   Ca+2↑, 1,   Ca+2↝, 2,   Cartilage↑, 1,   COL1↓, 4,   COL1↑, 1,   COL3A1↓, 2,   E-cadherin↑, 2,   EMT↓, 3,   Fibronectin↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 3,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 5,   MMP9↑, 1,   MUC1↑, 2,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   Smad7↑, 1,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TGF-β1↓, 2,   TIMP1↓, 1,   TumCI↓, 1,   TumMeta↓, 1,   Twist↑, 1,   TXNIP↓, 2,   Tyro3↓, 1,   uPA↑, 1,   Vim↓, 3,   Vim↑, 1,   α-SMA↓, 10,   α-SMA↑, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   eNOS↑, 1,   Hif1a↓, 3,   Hif1a↑, 2,   LOX1↓, 1,   NO↓, 20,   TXA2↓, 1,   VCAM-1↓, 6,   VEGF↓, 5,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 10,   BBB↝, 1,   BBB∅, 2,   GastroP↑, 10,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 3,   H+/K+-ATPase↓, 1,   IBI↑, 4,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 11,   OATPs↓, 1,   OCLN↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV3↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 4,   COX2/PTGS2↓, 39,   COX2/PTGS2↑, 2,   CXCL1↓, 1,   HMGB1↓, 1,   ICAM-1↓, 6,   IFN-γ↓, 10,   IL1?, 1,   IL1↓, 1,   IL10↓, 6,   IL10↑, 10,   IL12↓, 1,   IL17↓, 6,   IL18↓, 2,   IL1β↓, 39,   IL2↓, 4,   IL22↓, 1,   IL23↓, 1,   IL4↓, 5,   IL4↑, 1,   IL5↓, 1,   IL6?, 1,   IL6↓, 50,   IL6↑, 2,   IL8↓, 9,   Imm↓, 1,   Imm↑, 20,   Imm↝, 3,   Inflam↓, 158,   Inflam↑, 2,   IRF3↓, 1,   LPS↓, 2,   LTA/TNF-β↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 5,   MCT1↓, 1,   MIP2↓, 1,   MyD88↓, 4,   NeuroI↓, 2,   NF-kB↓, 67,   NK cell↑, 1,   NLRP3↓, 15,   NLRP3↑, 1,   p65↓, 3,   PGE2↓, 14,   RAGE↓, 1,   RANTES↓, 1,   TLR2↓, 1,   TLR4↓, 16,   TNF-α↓, 70,   TNF-α↑, 3,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 4,   Ach↑, 3,   AChE↓, 24,   AChE∅, 1,   BChE↓, 5,   BDNF↓, 1,   BDNF↑, 13,   ChAT↑, 3,   DHCR7↑, 1,   GABA↑, 2,   MAOA↓, 2,   MAOB↓, 2,   NGF↑, 4,   PSD95↑, 1,   SNAP25↑, 1,   TrkB↑, 3,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   APP↓, 1,   Aβ↓, 22,   Aβ42↓, 1,   BACE/β-secretase↓, 7,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   tau↓, 4,   p‑tau↓, 5,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 2,   ACE2↓, 1,   BNP↓, 1,   CYP19↓, 1,   Leptin↓, 1,   PPARα↑, 3,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 8,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 36,   BioAv↑, 39,   BioAv↝, 23,   BioEnh↑, 3,   ChemoSen↑, 3,   CompStab↑, 1,   CompStab↝, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 47,   eff↑, 19,   eff↝, 1,   GSTA1↑, 2,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 13,   P-gp/ABCB1↓, 3,   P450↓, 2,   P450↑, 2,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 77,   ALAT↑, 4,   ALB↑, 1,   ALP↓, 16,   AST↓, 75,   AST↑, 4,   BG↓, 5,   Bil↓, 4,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 6,   BP↓, 6,   BUN?, 1,   BUN↓, 4,   creat↓, 11,   CRP↓, 7,   hs-CRP↓, 2,   IL6?, 1,   IL6↓, 50,   IL6↑, 2,   IRes↑, 1,   IRes↝, 1,   LDH↓, 16,   LDH↑, 1,   NOS2↓, 2,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 4,   TMAO↓, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 4,   AntiAge↑, 9,   antiAll↑, 18,   AntiArt↑, 10,   AntiCan↑, 35,   antiCG↑, 1,   antiD↓, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 47,   antiNeop↑, 1,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 9,   cardioP?, 1,   cardioP↑, 76,   cardioP⇅, 1,   chemoP↑, 12,   chemoPv↑, 5,   cognitive↑, 27,   cough?, 1,   diuretic↑, 5,   fatigue↓, 3,   hepatoP↓, 10,   hepatoP↑, 255,   Learn↑, 1,   memory?, 1,   memory↑, 29,   Mood↑, 1,   motorD↓, 1,   motorD↑, 5,   Mucositis↓, 1,   neuroP?, 3,   neuroP↓, 2,   neuroP↑, 106,   Obesity↓, 20,   OS↑, 4,   Pain↓, 4,   PDE4↓, 1,   QoL↑, 1,   radioP↑, 9,   RenoP↓, 1,   RenoP↑, 46,   Sleep↑, 1,   SoreThr?, 1,   Stress↓, 2,   Stroke↓, 11,   toxicity↓, 32,   toxicity↑, 1,   toxicity↝, 15,   toxicity∅, 4,   Wound Healing↓, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 15,   AntiFungal↑, 10,   AntiViral↑, 13,   Bacteria↓, 33,   Bacteria↑, 1,   Diar↓, 3,   GutMicro↑, 23,   insect↑, 1,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↝, 12,   Phen↑, 1,   QC↑, 1,  
Total Targets: 574

Scientific Paper Hit Count for: hepatoP, L,hepatoprotective
23 Silymarin (Milk Thistle) silibinin
20 Thymoquinone
11 Silver-NanoParticles
10 Baicalein
9 Carvacrol
8 Emodin
8 Selenium NanoParticles
7 Resveratrol
7 Ferulic acid
7 Hydrogen Gas
6 Chlorogenic acid
6 Chrysin
6 Dandelion Root
6 Matrine
5 Allicin (mainly Garlic)
5 Curcumin
5 Ashwagandha(Withaferin A)
5 Kaempferol
5 Licochalcone A
5 Piperine
5 Rosmarinic acid
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Centella asiatica / Gotu kola → asiaticoside
4 Crocetin
4 EGCG (Epigallocatechin Gallate)
4 Isoliquiritigenin
4 Luteolin
4 Moringa oleifera
4 Quercetin
3 Berberine
3 Boron
3 buckwheat sprouts
3 Rutin
3 Chemotherapy
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Radiotherapy/Radiation
3 Hibiscus sabdariffa
3 Honokiol
3 Hyperoside
3 Isobavachalcone
3 Isovitexin
3 Linalool
3 Lycopene
3 Shikonin
2 Alpha-Lipoic-Acid
2 isoquercitrin
2 Apigenin (mainly Parsley)
2 Baicalin
2 doxorubicin
2 Betulinic acid
2 Selenium
2 Thymol-Thymus vulgaris
2 Sorafenib (brand name Nexavar)
2 Vitamin C (Ascorbic Acid)
2 Propolis -bee glue
2 methotrexate
2 Hydroxycinnamic-acid
2 Polyphenols
2 Cucurbitacin
2 Date Fruit Extract
2 Indole-3-carbinol
2 Flaxseed/Linseed
2 Fucoidan
2 Graviola
2 Licorice
2 Cisplatin
2 Mung Bean Sprouts
2 Vitexin
2 Metformin
2 Magnetic Fields
2 Morin
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Ursolic acid
1 1,8-Cineole
1 Astragalus
1 Gold NanoParticles
1 Acer okamotoanum
1 Artemisinin
1 Ascorbyl Palmitate
1 Melatonin
1 Astaxanthin
1 Biochanin A
1 Bacopa monnieri
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celastrol
1 Chlorophyllin
1 Choline
1 Chyawanprash
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Coenzyme Q10
1 Calorie Restriction Mimetics
1 Carvone
1 Diclofenac
1 diet Fermented Foods
1 Diindolylmethane
1 D-limonene
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Eugenol
1 Sesame seeds and Oil
1 Fenbendazole
1 Fennel Oil/Foeniculum vulgare
1 Fisetin
1 Formononetin
1 Gallic acid
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Helleborus niger extracts – Christmas Rose
1 Inositol
1 L-ornithine
1 Lactoferrin/Talactoferrin
1 Magnetic Field Rotating
1 Mucuna pruriens/Velvet Bean
1 Mistletoe/Viscum album Extracts
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Naringin
1 Neem
1 Paclitaxel/Taxol
1 Aidi injection
1 Propyl gallate
1 Piperlongumine
1 Pterostilbene
1 Capsaicin
1 α-Santalol/Sandalwood oil
1 Sulforaphane (mainly Broccoli)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1179  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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