KLF5 Cancer Research Results

KLF5, Krüppel-like factor 5: Click to Expand ⟱
Source:
Type:
KLF5 is a zinc finger transcription factor that plays crucial roles in regulating cell proliferation, differentiation, survival, migration, and angiogenesis.

– KLF5 is often overexpressed in certain subtypes and has been implicated in promoting cell proliferation and survival.

– Evidence suggests that high KLF5 levels can be associated with increased tumor aggressiveness and may contribute to resistance to therapy in some contexts.
Scientific Papers found: Click to Expand⟱
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, Synergy↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, Synergy↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

hyperG↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑GSK‐3β↑, 1,  

Cell Death(tgid=5) ⓘ

ASK1↑, 1,   BIM↑, 1,   Casp3↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   mTOR↑, 2,   PI3K↑, 2,   PKA↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

KLF2↓, 1,   KLF5↓, 1,   OCT4↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK4↑, 2,   CDK6↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Nanog↓, 1,   TumCG↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,   eff∅, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: KLF5, Krüppel-like factor 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1195  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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