| Source: |
| Type: |
| In healthy neurons, tau binds to and stabilizes microtubules, which are essential for maintaining cell structure and facilitating axonal transport. In AD, tau becomes abnormally hyperphosphorylated. This excessive phosphorylation reduces its affinity for microtubules, leading to destabilization of the cytoskeletal structure. -Abnormal phosphorylated tau (p-tau) can be detected in cerebrospinal fluid (CSF) and blood plasma. -Imaging techniques like tau PET scans can visualize tau deposits in the brain. Natural Products targeting tau -Curcumin via GSK-3β inhibition -Resveratrol Activates SIRT1 -EGCG inhibits Tau, but BBB penetration is questionable |
| 3271- | ALA, | Decrypting the potential role of α-lipoic acid in Alzheimer's disease |
| - | Review, | AD, | NA |
| 3441- | ALA, | α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice |
| - | in-vivo, | AD, | NA |
| 3819- | Aroma, | Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation |
| - | Human, | AD, | NA | - | in-vitro, | AD, | NA |
| 3687- | Ash, | Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives |
| - | Review, | AD, | NA |
| 4303- | Ash, | Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review |
| - | Review, | AD, | NA |
| 4305- | Ba, | Study on the Molecular Mechanism of Baicalin Phosphorylation of Tau Protein Content in a Cell Model of Intervention Cognitive Impairment |
| - | in-vitro, | NA, | SH-SY5Y |
| 4304- | Ba, | Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation |
| - | in-vitro, | AD, | NA |
| 3682- | BBR, | Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease |
| - | in-vitro, | AD, | NA |
| 3684- | BBR, | Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies |
| - | Review, | AD, | NA |
| 4298- | BBR, | Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance |
| - | in-vivo, | AD, | NA |
| - | in-vivo, | AD, | NA |
| 4300- | BBR, | Effect of berberine on cognitive function and β-amyloid precursor protein in Alzheimer’s disease models: a systematic review and meta-analysis |
| - | Review, | AD, | NA |
| 5483- | BM, | The Role of Bacopa monnieri in Alzheimer’s Disease: Mechanisms and Potential Clinical Use—A Review |
| - | Review, | AD, | NA |
| 5474- | BM, | Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation |
| 3791- | CA, | Caffeic Acid and Diseases—Mechanisms of Action |
| - | Review, | AD, | NA |
| 3854- | CAP, | Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice |
| - | in-vivo, | AD, | NA |
| 3855- | CAP, | Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice |
| - | in-vivo, | AD, | NA |
| 3889- | Cin, | Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models |
| - | in-vivo, | AD, | NA |
| 3894- | Cin, | Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis |
| - | in-vitro, | AD, | NA |
| 3888- | Cin, | Cinnamon, a promising prospect towards Alzheimer's disease |
| - | NA, | AD, | NA |
| 3893- | Cin, | Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro |
| - | Review, | AD, | NA |
| - | Review, | AD, | NA | - | Review, | Var, | NA |
| 3624- | Cro, | Crocus Sativus L. (Saffron) in Alzheimer's Disease Treatment: Bioactive Effects on Cognitive Impairment |
| - | Review, | AD, | NA |
| 3794- | CUR, | Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities |
| - | Review, | AD, | NA |
| 3793- | CUR, | Curcumin Downregulates GSK3 and Cdk5 in Scopolamine-Induced Alzheimer’s Disease Rats Abrogating Aβ40/42 and Tau Hyperphosphorylation |
| - | in-vivo, | AD, | NA |
| 3795- | CUR, | Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence |
| - | Review, | AD, | NA |
| 3588- | CUR, | The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies |
| - | Review, | AD, | NA |
| 3576- | CUR, | Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease |
| - | Review, | AD, | NA |
| 4290- | EGCG, | EGCG impedes human Tau aggregation and interacts with Tau |
| - | in-vitro, | AD, | NA |
| 4291- | EGCG, | Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro |
| - | in-vitro, | AD, | NA |
| 3591- | EGCG, | Epigallocatechin-3-Gallate Provides Protection Against Alzheimer's Disease-Induced Learning and Memory Impairments in Rats |
| - | in-vivo, | AD, | NA |
| 3592- | EGCG, | (-)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse model of Alzheimer's disease |
| - | in-vivo, | AD, | NA |
| 3830- | EMD, | Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 4071- | FA, | Folate and Alzheimer: when time matters |
| - | Review, | AD, | NA |
| 3782- | FA, | Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer’s disease-like pathology through Akt-ERK crosstalk pathway in male rats |
| - | in-vivo, | AD, | NA |
| 3715- | FA, | CUR, | PS, | The Additive Effects of Low Dose Intake of Ferulic Acid, Phosphatidylserine and Curcumin, Not Alone, Improve Cognitive Function in APPswe/PS1dE9 Transgenic Mice |
| - | in-vivo, | AD, | NA |
| 4025- | FulvicA, | Mumio (Shilajit) as a potential chemotherapeutic for the urinary bladder cancer treatment |
| - | in-vitro, | Bladder, | T24/HTB-9 | - | Review, | AD, | NA |
| 4017- | FulvicA, | Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease |
| - | NA, | AD, | NA |
| 4016- | FulvicA, | Shilajit: A Natural Phytocomplex with Potential Procognitive Activity |
| - | Review, | AD, | NA |
| 4020- | FulvicA, | Natural products as a rich source of tau-targeting drugs for Alzheimer’s disease |
| - | in-vitro, | AD, | NA |
| 4021- | FulvicA, | Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer’s Disease |
| - | in-vitro, | AD, | NA |
| 3723- | Gb, | Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies |
| - | Review, | AD, | NA |
| 4003- | Gins, | Neuroprotective Potentials of Panax Ginseng Against Alzheimer's Disease: A Review of Preclinical and Clinical Evidences |
| - | Review, | adrenal, | NA |
| 3829- | Gins, | Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 4302- | Gins, | Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease |
| - | Review, | AD, | NA |
| 4301- | Gins, | Red Ginseng Inhibits Tau Aggregation and Promotes Tau Dissociation In Vitro |
| - | in-vitro, | AD, | NA |
| 4243- | Gins, | Effects of Ginseng on Neurological Disorders |
| - | Review, | Stroke, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 4308- | H2, | A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer's disease therapy |
| - | in-vivo, | AD, | NA |
| 3768- | H2, | Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial |
| - | Trial, | AD, | NA |
| - | Review, | AD, | NA | - | Review, | Stroke, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:1231 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid