PINK1 Cancer Research Results

PINK1, PTEN-induced kinase 1: Click to Expand ⟱
Source:
Type:
PINK1 (PTEN-induced kinase 1) is a mitochondrial kinase that plays a critical role in maintaining mitochondrial quality control through mitophagy.
- Many studies indicate that lower PINK1 expression tends to correlate with more aggressive disease and poorer prognosis—likely due to compromised mitochondrial quality control.
Scientific Papers found: Click to Expand⟱
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, *ROS↑, *BloodF↑, *Pain↓, *antiOx↑, *Inflam↓, *AMPK↑, *SIRT3↑, *NRF2↑, *PINK1↑, *PARK2↑, *LC3B↑, *Beclin-1/ATG6↑, *TFAM↑, *NLRP3↓, *NF-kB↓, *COX2/PTGS2↓, *p62↓, *NP/CIPN↓,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
7438- CYN,    Cynaropicrin Suppresses Cell Proliferation by Inducing Mitophagy through p38 MAPK-Mediated Mitochondrial ROS Generation in Human Hepatocellular Carcinoma Cells
- in-vitro, HCC, NA
tumCV↓, TumAuto↑, selectivity↑, mt-ROS↑, MMP↓, LC3B↑, Beclin-1/ATG6↓, p62↓, PINK1↑, PARK2↑, eff↓, p‑MAPK↑,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, Synergy↑, Synergy↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
7837- ISQ,    Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation
- in-vivo, Nor, NA
*Dose↝, *autophagy↓, *ATG7↓, *BNIP3↓, *LC3B↓, *PINK1↓, *ROS↓, *SOD1↑, *SOD2↑, *NRF2↑, *NQO1↑, *HO-1↑, *NOX2↓, *NOX4↓, *DUOX1↓, *IL1β↓, *IL6↓, *TNF-α↓, *JAK↓, *STAT3↓, *Inflam↓,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- in-vitro, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
8501- MAG,    Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy
- vitro+vivo, neuroblastoma, NA
MMP↓, mtDam↑, ROS↑, PINK1↑, TumCG↓, OS↑, TumAuto↑, MitoP↑,
7383- MF,    Magneto mitochondrial dysfunction mediated cancer cell death using intracellular magnetic nano-transducers
- vitro+vivo, Var, NA
mtDam↑, Apoptosis↑, MitoP↑, Dose↝, Dose↝, eff↑, PINK1↑, PARK2↑,
8880- MOR,    Morin, a Natural Flavonoid, Activates the PINK1/Parkin Pathway to Induce Mitophagy, Promote Apoptosis, and Suppress Cancer Stemness in Pancreatic Cancer
- in-vitro, PC, NA
tumCV↓, TumCMig↓, TumCI↓, CSCs↓, N-cadherin↓, Snail↓, Zeb1↓, SOX2↓, Nanog↓, OCT4↓, E-cadherin↑, ALDH↓, mtDam↑, MMP↓, compV↓, mt-ROS↑, PINK1↑, PARK2↑, AMPK↑, LC3A↑, LC3B↑, MFN2↓, MitoP↑, Apoptosis↑, Casp3↑, Casp9↑, Cyt‑c↑,
4874- Uro,  EGCG,    A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease
- in-vivo, AD, NA
*motorD↑, *memory↑, *MitoP↑, *Aβ↓, *mitResp↑, *Nrf1↑, *PINK1↑, *PARK2↑, *ATG5↑, *Bcl-2↑, *H2O2↓, *ROS↓, *lipid-P↓, *mt-ATP↑,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2/PTGS2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *BioAv↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑, *chemoP↑,
2274- VitK2,    Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop
- in-vitro, Nor, SH-SY5Y
*Bcl-2↓, *BAX↑, *MMP↑, *ROS↓, *p62↓, *LC3A↑, *Dose↝, *Apoptosis↓, *PINK1↑, *PARK2↑,

Showing Research Papers: 1 to 12 of 12

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   MDA↑, 1,   ROS↑, 4,   mt-ROS↑, 2,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compV↓, 1,   MFN2↓, 1,   mtDam↑, 4,   PINK1↑, 7,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Bcl-xL↓, 1,   Casp3↑, 2,   cl‑Casp3↑, 2,   proCasp3↓, 1,   proCasp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   Mcl-1↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 2,   JAK2↓, 1,   p‑MAPK↑, 1,   mTOR↓, 1,   mTOR↑, 1,   p‑mTOR↓, 1,   p‑PI3K↓, 1,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HDAC↓, 1,   miR-139-5p↑, 1,   OCT4↓, 1,   SOX2↓, 1,   tumCV↓, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3A↑, 1,   LC3B↑, 2,   LC3II↑, 2,   MitoP↑, 4,   p62↓, 2,   PARK2↑, 6,   TumAuto↑, 4,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 3,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK6↓, 1,   cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 1,   Ki-67↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMI1↓, 1,   CSCs↓, 1,   Ki-67↓, 1,   Nanog↓, 1,   TumCG↓, 2,   TumCP↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 2,   MMP9↓, 1,   MMPs↓, 1,   N-cadherin↓, 2,   Snail↓, 2,   TumCI?, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumMeta↓, 1,   Vim↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,   MMP↓, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   Dose↝, 2,   eff↓, 3,   eff↑, 2,   selectivity↑, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   OS↑, 1,   toxicity↝, 1,  
Total Targets: 95

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   DUOX1↓, 1,   H2O2↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   NOX2↓, 1,   NOX4↓, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↑, 3,   ROS↓, 3,   ROS↑, 1,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mitResp↑, 1,   PINK1↓, 1,   PINK1↑, 4,   SIRT3↑, 1,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   mt-ATP↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   BNIP3↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

JAK↓, 1,   STAT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   Beclin-1/ATG6↑, 1,   LC3A↑, 1,   LC3B↓, 1,   LC3B↑, 1,   MitoP↓, 1,   MitoP↑, 1,   p62↓, 2,   PARK2↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

Cartilage↑, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1β↓, 2,   IL6↓, 2,   Inflam↓, 5,   NF-kB↓, 1,   NLRP3↓, 1,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 3,   Half-Life↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 1,   chemoP↑, 1,   memory↑, 2,   motorD↑, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 1,   Pain↓, 1,   RenoP↑, 1,   Strength↑, 1,   toxicity↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   AntiViral↑, 1,   GutMicro↑, 1,  
Total Targets: 71

Scientific Paper Hit Count for: PINK1, PTEN-induced kinase 1
2 Urolithin
1 Beta-Caryophyllene
1 Cannabidiol
1 Butyrate
1 Cynaropicrin
1 Ferulic acid
1 isoquercitrin
1 Ivermectin
1 Magnolol
1 Magnetic Fields
1 Morin
1 EGCG (Epigallocatechin Gallate)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1239  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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