TumCA Cancer Research Results

TumCA, Tumor Cell adhesion: Click to Expand ⟱
Source:
Type:
Tumor Cell adhesion
Scientific Papers found: Click to Expand⟱
5271- 3BP,    The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
- Review, Var, NA
selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,
5868- CA,    Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29 - in-vitro, CRC, LoVo
Apoptosis↑, TumCMig↓, uPA↓, MMPs↓, COX2/PTGS2↓, TumCA↓, MMP9↓, MMP2↓, chemoPv↑,
9116- Cim,    Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells
- Trial, CRC, NA
eff↑, Dose↝, OS↑, E-sel↓, TumCA↓,
9117- Cim,    Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression
- vitro+vivo, CRC, NA
OS↑, TumCA↓, TumMeta↓, E-sel↑,
6238- CUSP9,    A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
- Trial, GBM, NA
toxicity↓, TrxR↓, ROS↓, TumCI↓, TumCMig↓, TumCA↓, MMP2↓, MMP9↓, COX2/PTGS2↓, ALDH↓, TumAuto↑, P-gp/ABCB1↓, eff↑,
6590- DAS,    Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells
- in-vitro, Pca, NA
Src↓, ABL1↓, BioAv↑, TumCG↓, Dose↓, TumCA↓, TumCMig↓, TumCI↓,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, Synergy↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, Synergy↑,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
7695- IP6,    The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1β-stimulated colon cancer cells
- in-vitro, Colon, Caco-2
AntiCan↑, TumCA↓, TumCMig↓, MMP13↓, MMP3↓, MMP2↓, TIMP1↓, MMP1↓, MMP9↓, TIMP2↓,
7693- IP6,    Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: I. In vitro studies of adhesion, migration and invasion of MDA-MB 231 human breast cancer cells
- in-vitro, BC, MDA-MB-231
TumCA↓, MMP9↓,
9244- ISO, IH,    Isorhamnetin inhibits bladder cancer progression by mediating glycolysis through targeting the SRC/PI3K/Akt axis
- in-vitro, Bladder, 5637
TumCP↓, TumCMig↓, TumCI↓, TumCA↓, Glycolysis↓, TumCCA↑, Apoptosis↑, p‑Src↓, PI3K↓, Akt↓, mTOR↓, HK2↓, GLUT1↓, PFKFB3↓, ECAR↓, OCR↓, GlucoseCon↓, lactateProd↓,
8343- Lut,    Association of Lutein with Cancer: A Systematic Review of the Lutein Effects on Cellular Processes Involved in Cancer Progression
- Review, Var, NA
*antiOx↑, *Inflam↓, Risk↓, AntiCan∅, Apoptosis↑, ROS↓, NRF2↓, Akt↓, ERK↓, NF-kB↓, Bcl-2↓, BAX↑, Casp3↑, DNAdam↑, ROS↓, P53↑, PCNA↓, cycD1/CCND1↓, TumCP↓, Hif1a↓, NOTCH↓, miR-590-3p↑, TumCMig↓, TumCI↓, TumMeta↓, TumCA↓, *BioAv↓,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2/PTGS2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
4535- MAG,  5-FU,    Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways
- in-vitro, Cerv, NA
ChemoSen↑, TumCP↓, vinculin↓, TumCA↓, TumCMig↓, TumCI↓, p‑Akt↓, p‑PI3K↓, mTOR↓, E-cadherin↑, β-catenin/ZEB1↑, Snail↓, Slug↓,
8864- MOR,    Morin, a flavonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-MB‑231 partly through suppression of the Akt pathway
- vitro+vivo, BC, MDA-MB-231
*antiOx↑, *Inflam↓, *AntiCan↑, TumCA↓, TumCI↓, MMP9↓, N-cadherin↓, EMT↓, p‑Akt↓, Akt↓,
9307- MushMait,    Antitumoral Effects of D-Fraction from Grifola Frondosa (Maitake) Mushroom in Breast Cancer
- in-vitro, BC, NA
TumCP↓, TumCD↑, TumCMig↓, TumCI↓, TumMeta↓, tumCV↓, TumCA↓,
9017- Phyco,    Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
eff↑, TumCP↓, Tumccf↓, TumCCA↑, cycE/CCNE↓, CDK2↓, P21↑, Apoptosis↑, γH2AX↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, TumCMig↓, TumCA↑, angioG↓, COX2/PTGS2↓, PGE2↓, MAPK↓, toxicity↓,
8381- QC,  LT,    Mechanism of Quercetin and Luteolin on Colon Cancer Metastasis: Network Pharmacological Study and Experimental Validation
- vitro+vivo, Colon, CT26
AntiCan↑, TumCG↓, TumCA↓, TumCMig↓, TumCI↓,
2210- SK,    Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway
- in-vitro, BC, MGC803
TumCA↓, TumCI↓, TumCMig↓, MMP2↓, MMP7↓, TLR2↓, p65↓, NF-kB↓, eff↑, ROS↑,
4851- Uro,    Urolithin A suppressed osteosarcoma cell migration and invasion via targeting MMPs and AKT1
- in-vitro, OS, MG63
TumCMig↓, TumCI↓, TumCA↑, MMP2?, MMP9?,
9145- WN,    Dietary walnut altered gene expressions related to tumor growth, survival, and metastasis in breast cancer patients: a pilot clinical trial
- Trial, BC, NA
Dose?, Apoptosis↑, TumCA↓, TumCP↓, TumCMig↓, eff↑, Synergy↑,

Showing Research Papers: 1 to 21 of 21

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 21

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ARE↓, 1,   GSH↓, 1,   lipid-P↓, 1,   NRF2↓, 2,   ROS↓, 5,   ROS↑, 4,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

EGF↓, 1,   mtDam↑, 2,   OCR↓, 1,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 2,   ECAR↓, 1,   GAPDH↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   HK2↓, 2,   lactateProd↓, 1,   PFKFB3↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 7,   BAX↑, 2,   Bax:Bcl2↑, 2,   Bcl-2↓, 4,   Casp3↑, 4,   cl‑Casp3↑, 1,   Casp9↑, 2,   cl‑Casp9↑, 1,   Cyt‑c↑, 3,   iNOS↓, 1,   Mcl-1↓, 1,   MDM2↓, 1,   MOMP↑, 1,   NOXA↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ABL1↓, 1,   Akt↓, 6,   p‑Akt↓, 2,   EGFR↓, 1,   ERK↓, 2,   MAPK↓, 1,   mTOR↓, 3,   mTORC2↓, 1,   PI3K↓, 2,   p‑PI3K↓, 1,   Src↓, 1,   p‑Src↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cJun↓, 1,   cMyc↓, 1,   HDAC↓, 1,   miR-590-3p↑, 1,   other↝, 1,   TCF-4↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CUL1↝, 1,   CUL5↝, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   IRE1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   p62↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   hTERT/TERT↓, 1,   P53↑, 1,   PARP↓, 1,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 2,   P21↑, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   cFos↓, 1,   mTORC1↓, 1,   NOTCH↓, 1,   TumCG↓, 3,   TumCP↓, 7,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   E-cadherin↑, 2,   EMT↓, 2,   FAK↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2?, 1,   MMP2↓, 5,   MMP3↓, 1,   MMP7↓, 3,   MMP9?, 1,   MMP9↓, 7,   MMPs↓, 1,   N-cadherin↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 1,   TumCA↓, 18,   TumCA↑, 3,   TumCI↓, 13,   TumCMig↓, 16,   TumMeta↓, 3,   uPA↓, 2,   vinculin↓, 1,   β-catenin/ZEB1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   E-sel↓, 1,   E-sel↑, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CX43/GJA1↓, 1,   GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   HLA-I/II↑, 1,   ICAM-1↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 1,   NF-kB↓, 5,   p65↓, 1,   PGE2↓, 1,   TLR2↓, 1,   TLR4↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 3,   Dose?, 1,   Dose↓, 1,   Dose↝, 2,   eff↑, 5,   P-gp/ABCB1↓, 2,   RadioS↑, 1,   selectivity↑, 2,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   Tumccf↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiCan∅, 1,   chemoPv↑, 1,   OS↑, 2,   Risk↓, 1,   toxicity↓, 2,  
Total Targets: 155

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1↓, 1,   IL12↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 2,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   radioP↑, 1,  
Total Targets: 11

Scientific Paper Hit Count for: TumCA, Tumor Cell adhesion
2 Cimetidine
2 phytic acid, Inositol hexakisphosphate
1 3-bromopyruvate
1 Carnosic acid
1 CUSP9
1 Dasatinib/Phyrago
1 Fisetin
1 Gossypol/AT-101
1 Isorhamnetin
1 Lutein
1 Lycopene
1 Magnolol
1 5-fluorouracil
1 Morin
1 Mushroom Maitake
1 Phycocyanin
1 Quercetin
1 Luteolin
1 Shikonin
1 Urolithin
1 Walnut
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1265  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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