CYP2C6 Cancer Research Results

CYP2C6, CYP2C6: Click to Expand ⟱
Source:
Type:
CYP2C6 belongs to the cytochrome P450 family of enzymes, which are primarily involved in the metabolism of both endogenous and exogenous compounds—including drugs and potential carcinogens.

-More than 95% of drugs and natural products are metabolized by CYPs, of which CYP1A, CYP2C, CYP2D, and CYP3A are the most important.
Scientific Papers found: Click to Expand⟱
7751- ISL,  LE,    Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents
- in-vitro, Nor, NA
*CYP2C6↓, *CYP3A4↓, *P450↓, *other↑,
8496- MAG,    Metabolic interactions of magnolol with cytochrome P450 enzymes: uncompetitive inhibition of CYP1A and competitive inhibition of CYP2C
- in-vitro, Nor, NA
*CYP1A1↓, *CYP2C6↓,
2216- SK,    Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
- in-vivo, Nor, NA
*NRF2↑, *AhR↑, *CYP1A1↑, *CYP1A2↑, *CYP2C6↑, *CYP2D1↑, *CYP3A2↑, *NQO1↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NQO1↑, 1,   NRF2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2C6↓, 2,   CYP2C6↑, 1,   CYP2D1↑, 1,   CYP3A2↑, 1,   CYP3A4↓, 1,   P450↓, 1,  
Total Targets: 13

Scientific Paper Hit Count for: CYP2C6, CYP2C6
1 Isoliquiritigenin
1 Licorice
1 Magnolol
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1267  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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