FGF21 Cancer Research Results

FGF21, FGF21: Click to Expand ⟱
Source:
Type:
Fibroblast Growth Factor 21 (FGF21). FGF21 is best known as a metabolic regulator involved in energy homeostasis.

– FGF21 is an endocrine member of the fibroblast growth factor family primarily secreted by the liver, but also produced by adipose tissue and skeletal muscle.
Scientific Papers found: Click to Expand⟱
7171- CHA,    Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201
- vitro+vivo, GBM, DIPG
TumCG↓, TumCP↓, Apoptosis↓, OS↑, H3K9↓, SUV39H↓, eff↑, CSCs↓, SOX9↓, HGF/c-Met↓, FGF21↓, EGFR↓, PDGFR-BB↓, Wnt↓, MYCN↑, OLIG2↓, AURKB↓, HO-1↑, P21↑,
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
2269- dietMet,    Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice
- in-vivo, Nor, NA
*adiP↑, *FGF↑, *Insulin↓, *glucose↓, *Akt↑, *GSH↓, *PTEN↓, *FGF21↑, *PIP3↑,
2270- dietMet,    Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice
- in-vivo, Var, NA
Weight↓, TumVol↓, P21↑, p27↑, *adiP↑, *glucose↓, *IGF-1↓, *FGF21↑, *OS↑, Ki-67↓, Casp3↑, cycD1/CCND1↓,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AURKB↓, 1,   H3K9↓, 1,   MYCN↑, 1,   OLIG2↓, 1,   SUV39H↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   GSTs↑, 1,   HO-1↑, 1,   ROS↑, 2,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FGF21↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 1,   Casp3↑, 1,   HGF/c-Met↓, 1,   p27↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

SOX9↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 1,   HDAC1↓, 1,   PI3K↓, 1,   PTEN↑, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   Ki-67↓, 2,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MMPs↓, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   EGFR↓, 2,   HIF-1↓, 1,   PDGFR-BB↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMPs↑, 1,   EGFR↓, 2,   Ki-67↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   OS↑, 1,   TumVol↓, 1,   Weight↓, 1,  
Total Targets: 52

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   GSH↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 1,   mt-ROS↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 2,   FGF21↑, 3,   glucose↓, 2,   GlucoseCon↑, 1,   Glycolysis↑, 1,   H2S↑, 1,   HK2↑, 1,   PFK↑, 1,   PIP3↑, 1,   PKM2↑, 1,   PPARα↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FGF↑, 1,   IGF-1↓, 2,   mTOR↓, 1,   PTEN↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT4↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   cardioP↑, 1,   cognitive↑, 1,   neuroP↑, 2,   OS↑, 2,  
Total Targets: 37

Scientific Paper Hit Count for: FGF21, FGF21
3 diet Methionine-Restricted Diet
1 chaetocin
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1279  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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