PIP3 Cancer Research Results

PIP3, Phosphatidylinositol (3,4,5)-trisphosphate: Click to Expand ⟱
Source:
Type:
PIP3 is a key lipid second messenger that plays a central role in the PI3K/AKT signaling pathway.

– Increased PIP3 levels are a hallmark of cancers characterized by PI3K pathway activation.

– Mutations or amplifications in PI3K subunits and loss of PTEN function often result in sustained PIP3 production, thereby driving oncogenic processes.

– Elevated PIP3 signaling contributes to increased cell proliferation, survival, metabolic reprogramming, and metastatic potential.
Scientific Papers found: Click to Expand⟱
2269- dietMet,    Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice
- in-vivo, Nor, NA
*adiP↑, *FGF↑, *Insulin↓, *glucose↓, *Akt↑, *GSH↓, *PTEN↓, *FGF21↑, *PIP3↑,
8530- Matr,    Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition
- in-vitro, HCC, NA
TumCP↓, TumCMig↓, TumCI↓, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, EMT↓, PIP3↑, PTEN↑, p‑Akt↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

PIP3↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 1,   PTEN↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   EMT↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   Vim↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   glucose↓, 1,   PIP3↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   PTEN↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FGF↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

FGF21↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: PIP3, Phosphatidylinositol (3,4,5)-trisphosphate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1280  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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