LC3A Cancer Research Results

LC3A, Microtubule-associated protein 1 light chain 3 alpha: Click to Expand ⟱
Source:
Type:
LC3A is one of the isoforms of the LC3 family and plays a critical role in the autophagy pathway.

– Enhanced Autophagy and Tumor Survival: In some cancers, increased LC3A expression (and therefore autophagic activity) is associated with a cytoprotective response, helping tumor cells survive under stress conditions such as hypoxia, nutrient deprivation, or treatment-induced damage. This has been linked in some cases to more aggressive tumor behavior and resistance to therapies.
Scientific Papers found: Click to Expand⟱
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27/CDKN1B↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
8880- MOR,    Morin, a Natural Flavonoid, Activates the PINK1/Parkin Pathway to Induce Mitophagy, Promote Apoptosis, and Suppress Cancer Stemness in Pancreatic Cancer
- in-vitro, PC, NA
tumCV↓, TumCMig↓, TumCI↓, CSCs↓, N-cadherin↓, Snail↓, Zeb1↓, SOX2↓, Nanog↓, OCT4↓, E-cadherin↑, ALDH↓, mtDam↑, MMP↓, compV↓, mt-ROS↑, PINK1↑, PARK2↑, AMPK↑, LC3A↑, LC3B↑, MFN2↓, MitoP↑, Apoptosis↑, Casp3↑, Casp9↑, Cyt‑c↑,
8879- MOR,  doxoR,    Synergistic Effects of Morin and Doxorubicin Overcome Chemoresistance in Ovarian Cancer: Preclinical Insights From in vitro and in vivo Models
- vitro+vivo, Ovarian, OVCAR-3 - NA, Melanoma, A2780S
Dose↝, ChemoSen↑, cycA1/CCNA1↓, cycD1/CCND1↓, TumVol↓, Apoptosis↑, TumCCA↑, ROS↝, chemoP↑, TumAuto↑, ROS↓, SOD↑, Catalase↑, GSH↑, MDA↓, cardioP↑, mTOR↓, PI3K↓, Akt↓, Bcl-2↓, Casp3↑, Casp9↑, LC3A↑, ATG5↑, Beclin-1/ATG6↑,
2274- VitK2,    Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop
- in-vitro, Nor, SH-SY5Y
*Bcl-2↓, *BAX↑, *MMP↑, *ROS↓, *p62↓, *LC3A↑, *Dose↝, *Apoptosis↓, *PINK1↑, *PARK2↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   Copper↑, 1,   GPx4↓, 1,   GSH↓, 1,   GSH↑, 1,   HO-1↓, 1,   MDA↓, 1,   NRF2↓, 1,   ROS↓, 1,   ROS↑, 1,   ROS↝, 1,   mt-ROS↑, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compV↓, 1,   MFN2↓, 1,   mtDam↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Casp3↑, 3,   Casp9↑, 3,   Cyt‑c↑, 2,   DR5↑, 1,   survivin↓, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   PTEN↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

OCT4↓, 1,   SOX2↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   IRE1↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3A↑, 3,   LC3B↑, 1,   MitoP↑, 1,   p62↓, 1,   PARK2↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   p27/CDKN1B↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CSCs↓, 1,   Nanog↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   CAFs/TAFs↓, 1,   E-cadherin↑, 2,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 2,   ROCK1↓, 1,   Snail↓, 2,   TumCI↓, 2,   TumCMig↓, 1,   Twist↓, 1,   Vim↓, 2,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PD-L1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoP↑, 1,   TumVol↓, 1,  
Total Targets: 81

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PINK1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↑, 1,   Bcl-2↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3A↑, 1,   p62↓, 1,   PARK2↑, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  
Total Targets: 10

Scientific Paper Hit Count for: LC3A, Microtubule-associated protein 1 light chain 3 alpha
2 Morin
1 Baicalein
1 doxorubicin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1282  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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