PKM1 Cancer Research Results

PKM1, pyruvate kinase muscle isoform 1: Click to Expand ⟱
Source:
Type:
PKM1 (pyruvate kinase muscle isoform 1) is one of the isoenzymes of pyruvate kinase that drives the final step of glycolysis by converting phosphoenolpyruvate to pyruvate, with concomitant ATP production. Unlike PKM2, which is well known for its role in cancer metabolism (often favoring anabolic processes and rapid proliferation), PKM1 is constitutively active and promotes a more oxidative metabolism.

• In many cancers, a metabolic switch is observed where PKM2 is preferentially expressed to allow for metabolic flexibility and support biosynthetic needs. As a result, PKM1 is less frequently expressed in these tumor types.

• However, some studies have reported contexts in which a higher PKM1/PKM2 ratio is observed, which might be associated with a more oxidative and less proliferative metabolic state.
Scientific Papers found: Click to Expand⟱
6419- MEL,    The potential influence of melatonin on mitochondrial quality control: a review
- Review, Nor, NA
*mt-ACC⇅, *PKM1↑, *PKM2↑, *Glycolysis↝, *PDKs↑, *FAO↑, *ETC↑, *OXPHOS↑, *ATP↑, Glycolysis↓, OXPHOS↑, *Ca+2↓, *ROS↓, *antiOx↑, *SOD2↑, *GPx↑, *Catalase↑, *MFN1↑, *MFN2↑, *OPA1↑, *YAP/TEAD↑, *Hippo↑, *SIRT1↑, *PGC-1α↑, *DRP1/DNM1L↓,
2409- PTS,    Pterostilbene Induces Pyroptosis in Breast Cancer Cells through Pyruvate Kinase 2/Caspase-8/Gasdermin C Signaling Pathway
- in-vitro, BC, EMT6 - in-vitro, BC, 4T1 - in-vitro, Nor, HC11
Pyro↑, Glycolysis↓, *toxicity∅, selectivity↑, GSDMC↑, PKM2↓, PKM1↑, GlucoseCon↓, lactateProd↓, ATP↓, TumCG↓,
2431- QC,    The Protective Effect of Quercetin against the Cytotoxicity Induced by Fumonisin B1 in Sertoli Cells
- in-vitro, Nor, TM4
*Apoptosis↓, *ROS↓, *antiOx↓, *MMP↑, *GPI↑, *HK2↑, *ALDOA↑, *PKM1↑, *LDHA↑, *PFKL↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   Glycolysis↓, 2,   lactateProd↓, 1,   PKM1↑, 1,   PKM2↓, 1,  

Cell Death ⓘ

GSDMC↑, 1,   Pyro↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

DRP1/DNM1L↓, 1,   MFN1↑, 1,   MFN2↑, 1,   OPA1↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   OXPHOS↑, 1,   ROS↓, 2,   SOD2↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   ETC↑, 1,   MMP↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

mt-ACC⇅, 1,   ALDOA↑, 1,   FAO↑, 1,   Glycolysis↝, 1,   GPI↑, 1,   HK2↑, 1,   LDHA↑, 1,   PDKs↑, 1,   PFKL↑, 1,   PKM1↑, 2,   PKM2↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Hippo↑, 1,   YAP/TEAD↑, 1,  

Migration ⓘ

Ca+2↓, 1,  

Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 32

Scientific Paper Hit Count for: PKM1, pyruvate kinase muscle isoform 1
1 Melatonin
1 Pterostilbene
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1306  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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