GSDMD Cancer Research Results

GSDMD, gasdermin D: Click to Expand ⟱
Source:
Type:
GSDMD is best known for its central role in mediating pyroptosis, a form of inflammatory programmed cell death.

-Some studies suggest that increased GSDMD expression and associated pyroptosis may improve local antitumor immunity.
-Some preclinical studies indicate that enhanced pyroptosis via GSDMD activation may correlate with a better prognosis, likely through improved immune-mediated clearance of tumor cells.
Scientific Papers found: Click to Expand⟱
6148- Citrate,  immuno,    Sodium Citrate Nanoparticles Induce Dual-Path Pyroptosis for Enhanced Antitumor Immunotherapy through Synergistic Ion Overload and Metabolic Disturbance
- in-vitro, Var, NA
Dose↝, GSDMD↑, Pyro↑, eff↑,
6829- EMD,    Molecular Mechanisms of Action of Emodin: As an Anti-Cardiovascular Disease Drug
*diuretic↑, *Bacteria↓, *AntiViral↑, *Inflam↓, AntiCan↑, *cardioP↑, *NF-kB↓, *TNF-α↓, *IL1β↓, *NO↑, *eNOS↑, *PPARγ↑, *Casp9↓, *Casp3↓, *GSDMD↓, *Bcl-2↑, *STAT3↑, *ATP↑, *SOD↑, *GSH↑, *HDAC2↓, *SIRT3↑, ROS↑, PCNA↓, P53↑, cMyc↓,
6865- FA,    Ferulic Acid Regulates GSDMD through the ROS/JNK/Bax Mitochondrial Apoptosis Pathway to Induce Pyroptosis in Lung Cancer
- in-vitro, Lung, NA
TumCP↓, MMP↓, LDH↑, Pyro↑, GSDMD↑, ROS↑, JNK↑, BAX↑,
7201- GGB,    Ginkgolide B Inhibits EMT and Promotes Pyroptosis in Gastric Cancer via AKT/mTOR Pathway
- vitro+vivo, GC, AGS - in-vitro, GC, HGC27
TumCI↓, TumCMig↓, Apoptosis↑, Pyro↑, BAX↑, GSDMD↑, Bcl-2↓, TumCG↓, EMT↓, PCNA↓, N-cadherin↓, E-cadherin↑, PI3K↓, Akt↓, mTOR↓, Dose↝,
2509- H2,    Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
- in-vitro, Endo, AN3CA - in-vivo, Endo, NA
selectivity↑, mt-ROS↑, ROS↑, TumW↓, GSDMD↑, Pyro↑, Dose↝, eff↓, TumVol↓,
2508- H2,    Molecular hydrogen is a promising therapeutic agent for pulmonary disease
- Review, Var, NA - Review, Sepsis, NA
*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑,
3471- MF,    The prevention effect of pulsed electromagnetic fields treatment on senile osteoporosis in vivo via improving the inflammatory bone microenvironment
- in-vivo, Nor, NA
*BMD↑, *NLRP3↓, *proCasp1↓, *cl‑Casp1↓, *IL1β↓, *GSDMD↓,
3472- MF,    GSDMD_signaling_path">Pulsed electromagnetic field alleviates synovitis and inhibits the NLRP3/Caspase-1/GSDMD signaling pathway in osteoarthritis rats
- in-vivo, ostP, NA
*Inflam↓, *NLRP3↓, *Casp1↓, *GSDMD?,
2961- PL,    Piperlongumine inhibits esophageal squamous cell carcinoma in vitro and in vivo by triggering NRF2/ROS/TXNIP/NLRP3-dependent pyroptosis
- in-vitro, ESCC, KYSE-30
Pyro↑, TumCP↓, TumCMig↓, TumCI↓, ASC↑, cl‑Casp1↑, NLRP3↑, GSDMD↑, ROS↑, NRF2↓, TXNIP↑,
6422- QC,    Quercetin Protects Ethanol-Induced Hepatocyte Pyroptosis via Scavenging Mitochondrial ROS and Promoting PGC-1α-Regulated Mitochondrial Homeostasis in L02 Cells
- in-vitro, Alcohol, L02
*mt-ROS↓, *lipid-P↓, *MMP↑, *mtDam↓, *NLRP3↓, *ASC↓, *cl‑Casp1↓, *IL18↓, *IL1β↓, *GSDMD↓, *Pyro↓, *CYP2E1↓, *MFN1↓, *MFN2↓, *OPA1↓, *DRP1/DNM1L↑,

Showing Research Papers: 1 to 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↓, 1,   ROS↑, 5,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   LDH↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 2,   Bcl-2↓, 1,   cl‑Casp1↑, 1,   GSDMD↑, 6,   JNK↑, 1,   Pyro↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   PCNA↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 2,   TXNIP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 3,   eff↓, 1,   eff↑, 2,   eff↝, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoP↑, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 38

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

diuretic↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   CYP2E1↓, 1,   GSH↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MFN1↓, 1,   MFN2↓, 1,   MPO↑, 1,   NRF2↑, 1,   OPA1↓, 1,   ROS↓, 1,   mt-ROS↓, 1,   SIRT3↑, 1,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   DRP1/DNM1L↑, 1,   MMP↑, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

NADPH↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

ASK1↓, 1,   Bcl-2↑, 1,   Casp1↓, 1,   cl‑Casp1↓, 2,   proCasp1↓, 1,   Casp3↓, 1,   Casp9↓, 1,   GSDMD?, 1,   GSDMD↓, 3,   Pyro↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC2↓, 1,   STAT3↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

eNOS↑, 1,   NO↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   HMGB1↓, 1,   IL18↓, 1,   IL1β↓, 3,   Inflam↓, 3,   NF-kB↓, 1,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 3,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 48

Scientific Paper Hit Count for: GSDMD, gasdermin D
2 Hydrogen Gas
2 Magnetic Fields
1 Citric Acid
1 immunotherapy
1 Emodin
1 Ferulic acid
1 Ginkgolide B
1 Piperlongumine
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1317  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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