condition found tbRes List
sonoP, sonoporation: Click to Expand ⟱
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Sonoporation is a technique that uses ultrasound waves to transiently increase the permeability of cell membranes, allowing for the enhanced delivery of drugs, genes, or other therapeutic agents into cells.

-Microbubbles (gas-filled contrast agents commonly used in ultrasound imaging) are often administered alongside the therapeutic agent. When exposed to ultrasound, these microbubbles oscillate and can collapse (a process known as cavitation). This cavitation enhances the permeability of nearby cell membranes, thus facilitating drug or gene uptake.
Scientific Papers found: Click to Expand⟱
2548- SDT,    Sonoporation, a Novel Frontier for Cancer Treatment: A Review of the Literature
- Review, Var, NA
sonoP↑, Sonoporation has garnered significant attention for its potential to temporarily permeabilize cell membranes through the application of ultrasound waves, thus enabling an efficient cellular uptake of molecules
Dose↝, When, however, the acoustic intensity (ISATA) exceeds a certain threshold, typically 5 W/cm2 [8,9], the microbubble collapses forcefully, mechanically breaking the membrane;
eff↓, very low-intensity ultrasound (VLIUS) to tumor and normal cells, revealing that a specific VLIUS intensity (120 mW/cm2) significantly enhanced the uptake of nanoparticles and improved the delivery of the chemotherapy drug trabectedin in cancer cells
Dose↝, nanoparticles were combined with low-intensity focused ultrasound with a frequency of 1.0 MHz, a duty cycle of 50%, and an acoustic intensity of 2000, 2400, and 2800 mW/cm2
BioEnh↑,
toxicity↝, Ultrasound, especially at high acoustic intensities, can induce collateral damages that are not easy to predict; this is why low-intensity applications must be promoted.

2549- SDT,    Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
- Review, Var, NA
sonoP↑, Numerous studies have provided us with firm evidence that sonoporation may assist cancer treatment through effective drug and gene delivery. provide greater drug distribution within tissues.
tumCV↓, Until now, numerous studies have reported various cellular alterations caused by US, e.g., a decreased viability [23], disrupted cell membrane potential [24,25], altered calcium signalling [26,27], production of reactive oxygen species
MMP↓,
ROS↑, When the gas pressure increases significantly or the temperature rapidly rises during the collapse of MBs, such extreme conditions can generate reactive oxygen species (ROS) as well as electromagnetic waves
Ca+2↑, an increased intracellular concentration of Ca2+ ions is known to induce the production of free radicals by mitochondria.
eff↝, US, microbubble responds in a wide range of behaviours that cause acoustic cavitation
eff↑, Several studies have shown that the higher the concentration of MBs, the more intensified the sonoporation and the bigger the pores in the cell membrane
selectivity↑, Interestingly, they found that MCF-7/ADR cells displayed a higher sensitivity to sonoporation
Half-Life↝, discovered that the size of the generated pore determined the reversibility of the sonoporation: membrane perforations smaller than 30 μm2 disappeared within 1 min after US treatment, whereas pores >100 μm2 were still open within half an hour.
Dose↝, Whereas US exposure at 0.75 W/cm2 provided the highest level of methane dicarboxylic aldehyde (MDA) in doxorubicin resisted cells
P-gp↓, Microbubble-based sonoporation has been shown to reduce the expression of Pgp in the blood-brain barrier in rats. Aryal et al. [136] observed a suppression of Pgp that lasted more than 72 h.
ER Stress↑, Zhong et al. revealed that sonoporation is not only capable of ER stress induction but also that these signals can be transduced to mitochondria and guide US-treated cells toward apoptosis.
other↑, This review has clearly highlighted that ultrasound (US)-triggered bioeffects are not limited to the cell membrane, but they also alter cell functioning at diverse levels.

2550- SDT,    Intracellular Delivery and Calcium Transients Generated in Sonoporation Facilitated by Microbubbles
- in-vitro, Nor, NA
*Ca+2↑, Only cells adjacent to the ultrasound-driven microbubble exhibited propidium iodide (PI) uptake with simultaneous [Ca2+]i increase and fura-2 dye loss.
sonoP↑, Sonoporation has the ability to enhance the delivery of large-molecular weight drugs, genes, and proteins to cells,
BioEnh↑,

2551- SDT,    Sonoporation: Past, Present, and Future
- Review, Var, NA
other↝, several novel non-bubble-based sonoporation mechanisms are under development
sonoP↑, This review will cover both the bubble-based and non-bubble-based sonoporation mechanisms being employed for intracellular delivery,
Dose↝, Sonoporation enhances the intracellular delivery of cargos into cells by employing acoustic waves to disrupt their membranes.

2539- SNP,  SDT,    Combined effect of silver nanoparticles and therapeutical ultrasound on ovarian carcinoma cells A2780
- in-vitro, Melanoma, A2780S
tumCV↓, Experimental results indicate a significant decrease of viability of cell, which was affected by the combined action of ultrasound field and silver nanoparticles, compared to the separate exposure of silver nanoparticles or ultrasonic field.
sonoP↑, One of the characteristic effects of sonodynamic therapy is the loosening of cell membranes, thus causing their increased porosity
BioEnh↑,


* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Results for Effect on Cancer/Diseased Cells:
BioEnh↑,3,   Ca+2↑,1,   Dose↝,4,   eff↓,1,   eff↑,1,   eff↝,1,   ER Stress↑,1,   Half-Life↝,1,   MMP↓,1,   other↑,1,   other↝,1,   P-gp↓,1,   ROS↑,1,   selectivity↑,1,   sonoP↑,5,   toxicity↝,1,   tumCV↓,2,  
Total Targets: 17

Results for Effect on Normal Cells:
Ca+2↑,1,  
Total Targets: 1

Scientific Paper Hit Count for: sonoP, sonoporation
5 SonoDynamic Therapy UltraSound
1 Silver-NanoParticles
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1318  State#:%  Dir#:%
  wNotes=on  sortOrder:rid,rpid

 

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