HDAC6 Cancer Research Results

HDAC6, HDAC6: Click to Expand ⟱
Source:
Type:
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that plays a significant role in regulating various cellular processes, and its dysregulation has been implicated in cancer pathogenesis and progression.
-HDAC6 primarily deacetylates non-histone proteins, including α-tubulin and heat shock protein 90 (Hsp90).
-Many studies have reported overexpression or hyperactivation of HDAC6 in different cancer types.
Scientific Papers found: Click to Expand⟱
9185- BITC,  PEITC,  AITC,  ITCs,    Effects of Brassicaceae Isothiocyanates on Prostate Cancer
- Review, Pca, NA
antiOx↑, Inflam↓, Bacteria↓, chemoPv↑, TumCCA↑, Apoptosis↑, ChemoSen↑, TumCP↓, TumCI↓, TumMeta↓, DNMTs↓, HDAC↓, HDAC6↓, AR↓, selectivity↑, CDK1↓, CycB/CCNB1↓, P53↑, WEE1↑, CDC25↓, cMyc↓, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, XIAP↓, survivin↓, Bcl-2↓, compIII↓, APAF1↑, ROS↑, OXPHOS↓, MMP↓, Ca+2↑, CXCR4↓, IL6↓, JAK2↓, STAT3↓, mTOR↓, Synergy↑, CSCs↓, uPAR↓, NF-kB↓, TGF-β↓, angioG↓,
9287- BR, BRJ,    Anticancer and Anti-Inflammatory Potential of Betalains: A Systematic Review on Preclinical Studies
- Review, Var, NA
tumCV↓, TumCP↓, Apoptosis↑, Casp↑, TumCCA↑, Inflam↓, NF-kB↓, CCN2/CTGF↓, IL6↓, COX2/PTGS2↓, iNOS↓, toxicity↓, *ROS↓, ROS↑, *SOD↑, *Catalase↑, PI3K↓, Akt↓, mTOR↓, DNMT1↓, DNMT3A↓, DNMT3B↓, HDAC6↓,
2878- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6-mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
TumCMig↓, TumCI↓, MMP9↓, α-tubulin↑, HDAC6↓, HSP90↓,
2874- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6‐mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
MMP9↓, α-tubulin↑, TumCI↓, HDAC6↓, HSP90↓, TumCMig↓, EGFR↓,
3359- QC,    Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells
- in-vitro, Cerv, HeLa
DNMTs↓, HDAC↓, HMTs↓, DNMT3A↓, EZH2↓, HDAC1↓, HDAC2↓, HDAC6↓, HDAC11↓, G9a↓, TIMP3↑, PTEN↑, SOCS1↑,
9188- SFN,    Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside
- Review, Pca, NA
chemoPv↑, antiNeop↑, Risk↓, Ingr↝, NRF2↑, NQO1↑, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, STAT3↓, Bcl-2↓, cycD1/CCND1↓, survivin↓, HDAC↓, DNMTs↓, HDAC3↓, HDAC6↓, Akt↓, TumCG↓, BioAv↑, Half-Life↝, PSA↓, PSADT↑,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   compIII↓, 1,   OXPHOS↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis↑, 3,   Bcl-2↓, 2,   Casp↑, 1,   Cyt‑c↑, 1,   iNOS↓, 1,   survivin↓, 2,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   EGFR↓, 1,   JAK2↓, 1,   mTOR↓, 2,   PI3K↓, 1,   PTEN↑, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   DNMT1↓, 1,   DNMT3A↓, 2,   DNMT3B↓, 1,   DNMTs↓, 3,   EZH2↓, 1,   HDAC↓, 3,   HDAC1↓, 1,   HDAC11↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC6↓, 6,   HMTs↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

G9a↓, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK4↓, 1,   CDK6↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   TumCCA↑, 2,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   TumCG↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   CCN2/CTGF↓, 1,   MMP9↓, 2,   TGF-β↓, 1,   TIMP3↑, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumMeta↓, 1,   uPAR↓, 1,   α-tubulin↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CXCR4↓, 1,   IL6↓, 2,   Inflam↓, 2,   NF-kB↓, 2,   PSA↓, 1,   SOCS1↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   Half-Life↝, 1,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 1,   EZH2↓, 1,   IL6↓, 2,   PSA↓, 1,   PSADT↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,   chemoPv↑, 2,   Risk↓, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 87

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   ROS↓, 1,   SOD↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: HDAC6, HDAC6
2 Honokiol
1 Benzyl isothiocyanate
1 Phenethyl isothiocyanate
1 Allyl isothiocyanate
1 Isothiocyanates
1 Beetroot
1 Quercetin
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1335  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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