ITGB3 Cancer Research Results

ITGB3, integrin β3: Click to Expand ⟱
Source:
Type:
Integrin β3 is a subunit of several integrin receptors (most notably αvβ3) that play key roles in cell adhesion, migration, signaling, and survival.
- Integrin β3 levels could serve as a biomarker for aggressive and metastatic tumors


Scientific Papers found: Click to Expand⟱
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, Var, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, Synergy↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
3242- EGCG,    Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains
- in-vitro, Nor, NA
ITGB3↓,
7694- IP6,    Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: II. Effects on integrins and focal adhesions
- in-vitro, BC, MDA-MB-231
ITGA5↓, ITGB3↓,
8819- MCP,  PacT,    Pectasol‐C Modified Citrus Pectin targets Galectin‐3‐induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids
- in-vitro, Ovarian, SKOV3
Gal-3↓, ChemoSen↑, STAT3↓, Hif1a↓, Akt↓, TumCMig↓, TumCI↓, ITGA2↓, ITGA5↓, ITGA6↓, ITGB1↓, ITGB3↓, ITGB4↓,
8756- MeSA,    THE MAIN CYTOTOXIC EFFECTS OF METHYLSELENINIC ACID ON VARIOUS CANCER CELLS
- Review, Var, NA
ROS↑, GSH↓, RadioS↑, angioG↓, p‑Akt↓, IκB↓, NF-kB↓, ITGB3↓, p‑FOXO3↓, BAX↑, Cyt‑c↑, proCasp3↑, PARP↑, Glycolysis↓, TCA↓, NRF2↑, DNMT1↓, Hif1a↓, ER Stress↑, ChemoSen↑,
8763- MeSA,    Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin β3 Signaling
- vitro+vivo, Nor, HUVECs
eff↑, angioG↓, ITGB3↓, p‑Akt↓, p‑IκB↓, p‑NF-kB↓,
3481- MF,    No effects of pulsed electromagnetic fields on expression of cell adhesion molecules (integrin, CD44) and matrix metalloproteinase-2/9 in osteosarcoma cell lines
- in-vitro, OS, MG63 - in-vitro, OS, SaOS2
ITGA1∅, ITGB1∅, ITGA5∅, ITGB3∅, ITGB4∅, MMP2∅, MMP9∅, eff↑,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

frataxin↑, 1,   GSH↓, 1,   NRF2↑, 2,   ROS↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   GSK‐3β↓, 1,   NADPH↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 2,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   proCasp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Mcl-1↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   p‑Akt↓, 3,   IκB↓, 1,   p‑IκB↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DNMT1↓, 1,   p‑FOXO3↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

MGMT↓, 1,   P53↑, 1,   PARP↑, 1,  

Migration(tgid=13) ⓘ

EMT↓, 1,   FAK↓, 1,   ITGA1∅, 1,   ITGA2↓, 1,   ITGA5↓, 2,   ITGA5∅, 1,   ITGA6↓, 1,   ITGB1↓, 2,   ITGB1∅, 1,   ITGB3↓, 6,   ITGB3∅, 1,   ITGB4↓, 1,   ITGB4∅, 1,   MMP2↓, 1,   MMP2∅, 1,   MMP9↓, 1,   MMP9∅, 1,   MMPs↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   Vim↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Hif1a↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Gal-3↓, 1,   Inflam↓, 1,   NF-kB↓, 2,   p‑NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 3,   eff↑, 2,   RadioS↑, 1,   selectivity↑, 1,   Synergy↑, 1,  
Total Targets: 62

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: ITGB3, integrin β3
2 methylseleninic acid
1 Alpha-Lipoic-Acid
1 EGCG (Epigallocatechin Gallate)
1 phytic acid, Inositol hexakisphosphate
1 Modified Citrus Pectin
1 Paclitaxel/Taxol
1 Magnetic Fields
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1342  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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