PDE4 Cancer Research Results

PDE4, Phosphodiesterase 4: Click to Expand ⟱
Source:
Type:
Phosphodiesterase 4 (PDE4) has been increasingly implicated in the pathology of Alzheimer's Disease (AD), primarily due to its role in regulating cyclic AMP (cAMP) signaling in the brain.
-Hydrolyzes cAMP → AMP (thus decreasing cAMP levels)
-PDE4 inhibitors (like rolipram): Enhance memory in AD mouse models
Possible inhibitors:
Resveratrol, Baicalin, Luteolin, Quercetin, Apigenin, Icariin


Scientific Papers found: Click to Expand⟱
4986- ATV,  Dipy,    The combination of statins and dipyridamole is effective preclinically in AML, MM, and breast cancer
- Review, Var, NA
HMG-CoA↓, AntiAg↑, eff↑, Apoptosis↑, selectivity↑, *toxicity↓, TumCG↓, PDE4↓, other↑,
3785- Bor,    Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease
- Analysis, AD, NA
*Aβ↓, *antiOx↑, *IronCh↑, *PDE4↓,
6441- SAO,    Sandalwood Album Oil as a Botanical Therapeutic in Dermatology
- Review, PSA, NA
*Inflam↓, *eff↑, *5LO↓, *DPPH↓, *hepatoP↑, *ROS↓, *PGE2↓, *IL1β↓, *IL17↓, *PDE4↓, *tyrosinase↓, *AntiFungal↑, angioG↓, TumCG↓, DNAdam↑, *Snail↑, *Twist↑, *Vim↑, *EMT↓, *toxicity↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

HMG-CoA↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 2,  

Migration ⓘ

AntiAg↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

PDE4↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   DPPH↓, 1,   ROS↓, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   tyrosinase↓, 1,  

Migration ⓘ

5LO↓, 1,   Snail↑, 1,   Twist↑, 1,   Vim↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL17↓, 1,   IL1β↓, 1,   Inflam↓, 1,   PGE2↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

hepatoP↑, 1,   PDE4↓, 2,   toxicity↓, 2,  

Infection & Microbiome ⓘ

AntiFungal↑, 1,  
Total Targets: 20

Scientific Paper Hit Count for: PDE4, Phosphodiesterase 4
1 Atorvastatin
1 Dipyridamole
1 Boron
1 α-Santalol/Sandalwood oil
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1361  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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