LRP1 Cancer Research Results

LRP1, Low-Density Lipoprotein Receptor-Related Protein 1: Click to Expand ⟱
Source:
Type:
LRP1, Low-Density Lipoprotein Receptor-Related Protein 1
-LRP1 dysfunction or downregulation impairs Aβ clearance, contributing to amyloid pathology.
-involved in Aβ transport across the blood-brain barrier (BBB) and clearance via glial cells.

LRP1 supports malignancy by:
-Facilitating migration through integrin signaling
-Enhancing survival pathways (PI3K–AKT, ERK) in stressed tumor cells
-Modulating TGF-β signaling, which can promote EMT and immune evasion
-Supporting tumor–stroma crosstalk, especially via fibroblasts and macrophages


Scientific Papers found: Click to Expand⟱
7396- Amla,    Enhancing cognitive memory function using Phyllanthus emblica polysaccharides via modulating autophagy and reshaping the gut microbiota
- in-vivo, AD, NA
*Inflam↓, *antiOx↓, *GutMicro↑, *cognitive↑, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *IL4↑, *IL10↑, *TAC↑, *ATG5↑, *Beclin-1↑, *LC3B↑, *LRP1↑, *BACE/β-secretase↓, *APP↓, *Aβ↓, *tau↓,
5952- Cela,    Celastrol attenuates Alzheimer’s disease-mediated learning and memory impairment by inhibiting endoplasmic reticulum stress-induced inflammation and oxidative stress
- in-vivo, AD, NA
*memory↑, *Inflam↓, *ROS↓, *ER Stress↓, *neuroP↑, *Dose↝, *MDA↓, *SOD↑, *Catalase↑, *Aβ↓, BACE/β-secretase↓, LRP1↑, RAGE↓,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
3835- Moringa,    Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *AChE↓, *neuroP↑, *Mood↑, *cognitive↑, *memory↑, *Aβ↓, *BACE/β-secretase↓, *AEP↓, *IDE↑, *NEP↑, *LRP1↑, *PSD95↑, *STEP↓, *APP↓,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   antiD↓, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↑, 1,   MDA↓, 2,   ROS↓, 1,   SOD↑, 1,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   BUN↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3B↑, 1,  

Migration(tgid=13) ⓘ

APP↓, 2,   LRP1↑, 2,   PAI-1/SERPINE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL10↑, 1,   IL1β↓, 1,   IL4↑, 1,   IL6↓, 1,   Inflam↓, 3,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   PSD95↑, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AEP↓, 1,   Aβ↓, 3,   BACE/β-secretase↓, 2,   IDE↑, 1,   NEP↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 1,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 2,   Mood↑, 1,   neuroP?, 1,   neuroP↑, 2,   RenoP↑, 1,   STEP↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 53

Scientific Paper Hit Count for: LRP1, Low-Density Lipoprotein Receptor-Related Protein 1
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Celastrol
1 Hyperoside
1 Moringa oleifera
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1366  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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