BrainVol Cancer Research Results

BrainVol, Hippocampal Volume: Click to Expand ⟱
Source:
Type:
Brain volume is a key biomarker in Alzheimer’s disease (AD) and is closely associated with the progression of the disease
-AD is characterized by progressive brain shrinkage (atrophy)
-Hippocampus: One of the earliest and most affected areas; crucial for memory formation.
-Medial Temporal Lobe: Including the entorhinal cortex; important in converting short-term to long-term memory.
-Parietal and Frontal Lobes: Atrophy spreads here as the disease progresses, affecting language, spatial awareness, and executive function.
-MRI imaging is widely used to measure brain volume loss.
-Rate of volume loss can predict cognitive decline and transition from:
-Normal aging → Mild Cognitive Impairment (MCI) → Alzheimer’s Disease.

Rate of Brain Volume Loss
  Population Group	Estimated Brain Volume Loss / Year
  Healthy aging adults	~0.2–0.5%
  MCI patients	        ~1–2%
  AD patients	        ~2–3% or more


Scientific Papers found: Click to Expand⟱
6754- DHA,    Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial
- Trial, AD, NA
*DHA↑, *eff↝, *BrainVol∅, *cognitive∅,
4139- Ex,    Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases
- Review, AD, NA
*BDNF↑, *eff↑, *eff↑, *cognitive↑, *memory↑, *BrainVol↑, *TrkB↑, *GABA↑,
6867- FA,  Ang,    Effect of Feru-guard 100M on amyloid-beta deposition in individuals with mild cognitive impairment
- Trial, AD, NA
*Aβ∅, *BrainVol∅, *cognitive∅,
6961- FA,  VitB12,  VitB6,  Silicon,  Alum  B Vitamins Prevent Iron-Associated Brain Atrophy and Domain-Specific Effects of Iron, Copper, Aluminum, and Silicon on Cognition in Mild Cognitive Impairment
- Trial, AD, NA
*BrainVol↝, *cognitive↝, *cognitive↑, *Dose↝, *other↝, *Hcy/homoC↓, *Risk↓, *BrainVol∅, *BrainVol↑, *other↝, *cognitive↑, *cognitive↑, *other↝, *Risk↝,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   MPO↓, 1,   NRF2↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

DHA↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,   MAPK?, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IFN-γ↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   RANTES↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   BrainVol↑, 3,   BrainVol↝, 1,   BrainVol∅, 3,   GABA↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ∅, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 2,   eff↑, 2,   eff↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Hcy/homoC↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 4,   cognitive↝, 1,   cognitive∅, 2,   memory↑, 1,   Risk↓, 1,   Risk↝, 1,  
Total Targets: 42

Scientific Paper Hit Count for: BrainVol, Hippocampal Volume
1 Docosahexaenoic Acid
1 Exercise
1 Ferulic acid
1 Angelica archangelica / Garden Angelica
1 Folic Acid, Vit B9
1 Vitamin B12
1 Vitamin B6,pyridoxine
1 Silicic Acid
1 Aluminum
1 Ginger/6-Shogaol/Gingerol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1372  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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