BloodF Cancer Research Results

BloodF, Blood Flow: Click to Expand ⟱
Source:
Type:
Blood Flow

Scientific Papers found: Click to Expand⟱
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, *ROS↑, *BloodF↑, *Pain↓, *antiOx↑, *Inflam↓, *AMPK↑, *SIRT3↑, *NRF2↑, *PINK1↑, *PARK2↑, *LC3B↑, *Beclin-1/ATG6↑, *TFAM↑, *NLRP3↓, *NF-kB↓, *COX2/PTGS2↓, *p62↓, *NP/CIPN↓,
8994- Citicoline,    Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion
- Trial, AD, NA
*Dose?, *cognitive↑, *BloodF↑, *other↝, *IL1β↓, *eff↑,
6293- Cro,    Crocetin: an agent derived from saffron for prevention and therapy for cancer
- Review, Var, NA
*toxicity↓, *lipid-P↓, *neuroP↑, *BloodF↑, *BP↓, *RenoP↑, *ATP↑, AntiCan↑, TumCP↓, Apoptosis↑, lipid-P↓, ROS↓, GSTs↑, Catalase↑, SOD↑,
7428- CS,    Exploring the Cardiovascular Potential of Artichoke—A Comprehensive Review
- Review, Nor, NA
*BloodF↓, *BP↓,
7421- CS,    Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial
- Trial, Nor, NA
*hepatoP↑, *Dose↝, *toxicity↓, *BloodF↑, *ALAT↓, *AST↓, *Bil↓, *LDL↓, *HDL↓, *TG/TAG↓,
6732- Dipy,    Dipyridamole enhances ischaemia-induced arteriogenesis through an endocrine nitrite/nitric oxide-dependent pathway
- in-vivo, Nor, NA
*BloodF↑, *NO↑, *AntiAg↑, *AntiThr↑, *antiOx↑, *angioG↑,
6733- Dipy,    Dipyridamole reverses peripheral ischemia and induces angiogenesis in the Db/Db diabetic mouse hind-limb model by decreasing oxidative stress
- in-vivo, Diabetic, NA
*BloodF↑, *NO↑,
6735- Dipy,    Dipyridamole Reverses Peripheral Ischemia and Induces Angiogenesis in the Db/Db Diabetic Mouse Hind Limb Model by Decreasing Oxidative Stress
- in-vivo, Nor, NA
*AntiAg↑, *BloodF↑, *NOX↑, *antiOx↑, *NO↑,
7229- EGb 761,    Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia
- Review, AD, NA
*toxicity↓, *Dose↝, *ROS↓, *PAF↓, *memory↑, *BloodF↑, *antiOx↑, *Inflam↓, *Tinn↓,
7228- EGb 761,    Current Perspectives on the Beneficial Role of Ginkgo biloba in Neurological and Cerebrovascular Disorders
- Review, AD, NA
*Dose↝, *PAF↑, *AntiAg↑, *BloodF↑, *Inflam↓, *neuroP↑, *Stroke↓, *Dose↝, *Sepsis↓, *memory↑,
7829- FA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BioAv↑, *cognitive↓, *Dose↝, *neuroP↑, *Aβ↓, *BACE/β-secretase↓, *ADAM10↑, *Ac-histone H3↑, *BloodF↑, *IRes↑, *memory↑, *Dose↝,
6930- FLS,    40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice
- in-vivo, Nor, NA
*GlyFlow↑, *e-ADO↑, *Sleep↑, *Dose↝, *AQPs↑, BloodF↑,
6983- Form,    Formononetin enhances angiogenesis in diabetic wounds by inhibiting ferroptosis through suppression of mtROS-mediated xCT/GPX4 upregulation
- vitro+vivo, Nor, HUVECs - vitro+vivo, Diabetic, NA
*BloodF↑, *Ferroptosis↓, *eff↓, *mtDam↓, *xCT/SLC7A11↑, *GPx4↑, *Wound Healing↑, *CD31/PECAM-1↑, *mt-ROS↓,
7012- Fuc,    Fucoidan: A promising natural therapeutic agent for protecting human kidney health
- Review, EC, NA
*RenoP↑, *Inflam↓, *antiOx↑, *ROS↓, *BloodF↑, *diuretic↑, *BioAv↓, *BioAv↑, *MAPK↓, *ERK↑, *NLRP3↓, *NRF2↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *lipid-P↓, *DNAdam↓, *Fibrosis↓, *JAK2↓, *STAT3↓, *uricA↓, *COL1↓, *α-SMA↓, *SIRT1↑, *HO-1↑, *GLP-1R↑, *HMGB1↓, *RAGE↓, *NF-kB↓, *TGF-β1↓, *PI3K↓, *Akt↓, *GutMicro↑, *SCFAs↑, *Buty↑, *IBI↑, *TJ↑, *Dose↝,
7212- GBE,    The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *mitResp↑, *Casp9↓, *Casp3↓, *Apoptosis↓, *ATP↑, *neuroP↑, *IL1β↓, *IL6↓, *TNF-α↓, *PGE2↓, *memory↑, *cognitive↑, *BloodF↑, *lipid-P↓, *Aβ↓, *MAOA↓, *DA↑, *Dose↝, *toxicity↓,
8582- GBE,  Cro,  Sage,  MO,    A comprehensive systematic review of human trials investigating herbal treatments for Alzheimer’s disease and dementia
- Review, AD, NA
*NA↑, *cognitive↑, *eff↑, *BloodF↑, *MMP↝, *ROS↓, *SOD↑, *GSH↑, *AChE↓, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Mood?,
7649- HPT,  Rad,    A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy
- in-vivo, Laryn, FaDu
Dose↝, BloodF↑, Hypoxia↓, RadioS?,
7599- HPT,  Rad,    Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome
- Review, Var, NA
NA↑, RadioS↑, DNArepair↓, Hypoxia↓, EPR↑, LC↑, OS↑, *toxicity↓, Dose↝, BloodF↑, pH↝, Imm↑, HSP70/HSPA5↑,
7622- HPT,    A Review of the Current Clinical Evidence for Loco-Regional Moderate Hyperthermia in the Adjunct Management of Cancers
- Review, Var, NA
LC↑, OS↑, QoL↑, toxicity↓, Dose↝, Dose↝, ROS↑, DNArepair↓, EPR↑, DNAdam↑, HSP70/HSPA5↑, BloodF↑, Hypoxia↓,
7575- HPT,  Rad,  Chemo,  immuno,    From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy
- Analysis, Var, NA
RadioS↑, ChemoSen↑, Imm↑, BloodF↑, Hypoxia↓, Dose↝, DNArepair↓, e-pH↓,
7572- HPT,  Rad,    The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
RadioS↑, TumCD↑, BRCA2↓, Dose↝, BloodF↑, ROS↑, Imm↑,
7676- iod,    Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)
- in-vivo, BC, NA
TumCP↓, Apoptosis↑, Dose↝, other↑, BloodF↓, VEGF↓, UroPA↓, PPARα↓, DR4↑, Casp3↑, PPARγ↑, antiNeop↑, Risk↓, 6IL↑,
7850- ISQ,    Effect of quercetin glycosides on cognitive functions and cerebral blood flow: a randomized, double-blind, and placebo-controlled study
- Trial, Nor, NA
*Dose↝, *RT↓, *BloodF↑, *Aβ↓,
9068- L-THE,  PI,    An imaging approach for determining the mechanism of enhancement of intestinal absorption of an L-theanine supplement
- in-vivo, Nor, NA
*BioAv↑, *BloodF↑,
8278- LE,    Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
- Review, Var, NA
*Ingr↝, *AntiCan↑, *AntiDiabetic↑, *AntiBio↑, *Inflam↓, *antiAll↑, *hepatoP↑, *cough?, *SoreThr?, *toxicity↝, *cardioP↑, *BioAv↝, *PGE2↓, *COX2/PTGS2↓, *AntiAg↑, *ROS↓, *NLRP3↓, *NF-kB↓, *AP-1↓, TumCCA↑, Apoptosis↑, TumMeta↑, *Dose↝, *Dose↝, Ingr↝, TumAuto↑, LC3II↑, PI3K↓, Akt↓, mTOR↓, *cognitive↑, *BloodF↑, ChemoSen↑, ROS↓, *chemoP↑, ROS↑, tumCV↓, MMP↓, *AntiBio↑, *toxicity↝,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE/β-secretase↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *Synergy↑,
8734- M-Blu,    From Mitochondrial Function to Neuroprotection – An Emerging Role for Methylene Blue
- Review, AD, NA
*ETC↑, *compIV↑, *ROS↓, *NeuroI↓, *neuroP↑, *Stroke↓, *cognitive↑, *BBB↑, *BloodF↑, *NOS2↓, *lipid-P↓, *Inflam↓, *Synergy↑, *OCR↑, *compIV↑, *ATP↑, *Casp↓, *MMP↑, *tau↓,
8733- M-Blu,    Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
- Review, AD, NA - Review, Stroke, NA
*ETC↑, *ROS↓, *Inflam↓, *memfluid↑, *BloodF↑, *BBB↑, *OCR↑, *ATP↑, *BioAv↑, *Aβ↓, *compIV↑, *Stroke↓, *compI↑, *compII↑, *compIII↑, *GlucoseCon↑, *neuroG↑,
6541- MeSal,    Toxicology Answer: Oil of Wintergreen
- Review, Nor, NA
*Inflam↓, *Pain↓, *BioAv↝, *BloodF↑, *toxicity↑,
5241- MF,    A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment
- Review, Var, NA
other↑, BloodF↑, Glycolysis↓, ATP↓, VEGF↓, ROS↑, P-gp/ABCB1↓, Apoptosis↑, selectivity↑, Ca+2↑, Catalase↑,
6938- MF,    Effect of pulsed electromagnetic field therapy on prostate volume and vascularity in the treatment of benign prostatic hyperplasia: a pilot study in a canine model
- in-vivo, BPH, NA
*Dose↝, *toxicity↓, *BloodF↑, *Dose↝, *PV↓, *Inflam↓,
6937- MF,    Noninvasive treatment for men suffering from enlarged prostate
- Review, BPH, NA
*PV↓, *Inflam↓, *BloodF↑, *Dose↝,
6936- MF,  Ex,    Pulsed electromagnetic field with or without exercise therapy in the treatment of benign prostatic hyperplasia
- Trial, BPH, NA
*eff↑, *Synergy↑, *BloodF↑, *Diff↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *Dose↝, *UFR↑, *UR↓, *PSA↓, *other↑, *Inflam↓,
6940- MF,    Meta-analysis of the effectiveness and safety of magnetic stimulation for chronic pelvic pain
- Review, BPH, NA
*UFR↑, *other?, *Pain↓, *BloodF↑, *other↑, *Inflam↓, *QoL↑,
9113- PRO,    Does propranolol have a role in cancer treatment? A systematic review of the epidemiological and clinical trial literature on beta-blockers
- Review, Var, NA
ADRB2↓, Risk↓, other⇅, TumMeta↓, Inflam↓, angioG↓, EGFR↓, COX2/PTGS2↓, VEGF↓, Hypoxia↓, BloodF⇅, RadioS↑, PD-1↓, Synergy↓,
6439- T4O,    Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health-A systematic review of randomized controlled trials
- Review, Nor, NA
*BioAv↝, *toxicity↝, *BloodF↑, *Sleep↑,

Showing Research Papers: 1 to 36 of 36

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 36

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 2,   GSTs↑, 1,   lipid-P↓, 1,   ROS↓, 2,   ROS↑, 4,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 1,   Glycolysis↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 4,   Casp3↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   EGFR↓, 1,   mTOR↓, 1,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other⇅, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA2↓, 1,   DNAdam↑, 1,   DNArepair↓, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   TumMeta↓, 1,   TumMeta↑, 1,   UroPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hypoxia↓, 5,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

EPR↑, 2,   MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   DR4↑, 1,   Imm↑, 3,   Inflam↓, 1,   PD-1↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,   e-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

6IL↑, 1,   ADRB2↓, 1,   PPARα↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,   Dose↝, 7,   P-gp/ABCB1↓, 1,   RadioS?, 1,   RadioS↑, 4,   selectivity↑, 1,   Synergy↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↓, 1,   BloodF↑, 7,   BloodF⇅, 1,   EGFR↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   antiNeop↑, 1,   LC↑, 2,   OS↑, 2,   QoL↑, 1,   Risk↓, 2,   toxicity↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 66

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   Bil↓, 1,   Catalase↑, 1,   GPx↑, 1,   GPx4↑, 1,   GSH↑, 1,   HDL↓, 1,   HO-1↑, 2,   lipid-P↓, 4,   MDA↓, 1,   NOX↑, 1,   NRF2↑, 3,   ROS↓, 8,   ROS↑, 1,   mt-ROS↓, 1,   SOD↑, 3,   uricA↓, 1,   xCT/SLC7A11↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   compIV↑, 3,   ETC↑, 2,   mitResp↑, 1,   mtDam↓, 1,   OCR↑, 2,   PINK1↑, 1,   SIRT3↑, 1,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

e-ADO↑, 1,   ALAT↓, 1,   AMPK↑, 1,   ATP↑, 5,   Buty↑, 1,   GlucoseCon↑, 1,   GSK‐3β↓, 1,   LDL↓, 1,   SCFAs↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bax:Bcl2↓, 1,   Casp↓, 1,   Casp3↓, 2,   Casp9↓, 1,   Casp9↑, 1,   Ferroptosis↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   CREB↑, 1,   ERK↑, 1,   JAK2↓, 1,   MAPK↓, 1,   PI3K↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ac-histone H3↑, 1,   AntiThr↑, 1,   other?, 1,   other↑, 2,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

GRP78/BiP↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3B↑, 1,   p62↓, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   AP-1↓, 1,   COL1↓, 1,   Fibrosis↓, 1,   TGF-β1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↑, 1,   NO↑, 3,  

Barriers & Transport(tgid=15) ⓘ

AQPs↑, 1,   BBB↑, 3,   GlyFlow↑, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 1,   MMP↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   HMGB1↓, 1,   IL1β↓, 3,   IL33↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 13,   NeuroI↓, 1,   NF-kB↓, 4,   NLRP3↓, 3,   PAF↓, 1,   PAF↑, 1,   PGE2↓, 2,   PSA↓, 1,   RAGE↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   ADAM10↑, 1,   BDNF↑, 1,   DA↑, 1,   MAOA↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 5,   BACE/β-secretase↓, 2,   tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GLP-1R↑, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 4,   Dose?, 1,   Dose↝, 27,   eff↓, 1,   eff↑, 3,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   Bil↓, 1,   BloodF↓, 1,   BloodF↑, 26,   BP↓, 2,   IL6↓, 2,   IRes↑, 1,   NOS2↓, 1,   PSA↓, 1,   PV↓, 2,   RAGE↓, 1,   TG/TAG↓, 1,   UFR↑, 2,   UR↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 1,   chemoP↑, 1,   cognitive↓, 1,   cognitive↑, 6,   cough?, 1,   diuretic↑, 1,   hepatoP↑, 2,   memory↑, 5,   Mood?, 1,   neuroP↑, 6,   NP/CIPN↓, 1,   Pain↓, 3,   QoL↑, 1,   RenoP↑, 2,   RT↓, 1,   Sleep↑, 2,   SoreThr?, 1,   Stroke↓, 3,   Tinn↓, 1,   toxicity↓, 6,   toxicity↑, 1,   toxicity↝, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 166

Scientific Paper Hit Count for: BloodF, Blood Flow
5 Hyperthermia
5 Magnetic Fields
4 Radiotherapy/Radiation
3 Dipyridamole
2 Crocetin
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Ginkgo biloba-EGb 761
2 Ginkgo biloba
2 Methylene blue
1 Beta-Caryophyllene
1 Cannabidiol
1 Citicoline, CDP-Choline
1 Ferulic acid
1 Mung Bean Sprouts
1 Flickering Light Stimulation
1 Formononetin
1 Fucoidan
1 Salvia officinalis
1 Lemon Balm/Melissa officinalis
1 Chemotherapy
1 immunotherapy
1 iodine
1 isoquercitrin
1 L-Theanine
1 Piperine
1 Licorice
1 Luteolin
1 Methyl salicylate / Sweet Birch oil
1 Exercise
1 Propranolol
1 Terpinen-4-ol / Tea Tree Oil
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1374  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

Home Page