miR-221 Cancer Research Results

miR-221, miR-221: Click to Expand ⟱
Source:
Type:
miR-221 (usually discussed together with miR-222) is a context-dependent, predominantly oncogenic microRNA that promotes cell-cycle progression, EMT, invasion, therapy resistance, and immune evasion in many cancers. Unlike miR-15/101/206, miR-221 is often overexpressed rather than lost.
-In Cancer: frequently upregulated
Scientific Papers found: Click to Expand⟱
5727- BF,    Bufalin Inhibits Proliferation and Induces Apoptosis in Osteosarcoma Cells by Downregulating MicroRNA-221
- in-vitro, OS, U2OS
TumCP↓, Apoptosis↑, ROS↑, miR-221↓,
4707- CUR,    The Potential Role of Curcumin as a Regulator of microRNA in Colorectal Cancer: A Systematic Review
- Review, Var, NA
miR-497↑, miR-200c↑, miR-409-3p↑, miR-34a↑, miR-126↑, miR-145↑, miR-206↑, miR-491↑, miR-141↑, miR-429↑, miR-101↑, miR-15↑, miR-21↓, miR-155↓, miR-221↓, miR-222↓, miR-17↓, miR-130a↓, miR-27a-3p↓, miR-20↓,
8113- LA,    Analyzing of colorectal cancer related genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines
- in-vitro, CRC, HT-29 - in-vitro, CRC, SW480
BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MMP2↓, MMP9↓, miR-34a↑, miR-25-5p↑, miR-195↑, miR-27a-3p↑, Let-7↑, miR-106b↓, miR-17↓, miR-21↓, miR-155↓, miR-221↓, TumPF↓,
8281- LE,    A Licorice Roots Extract Induces Apoptosis and Cell Cycle Arrest and Improves Metabolism via Regulating MiRNAs in Liver Cancer Cells
- in-vitro, Liver, NA
Apoptosis↑, TumCCA↑, Let-7↑, miR-34b-5p↑, miR-122-5p↑, miR-126↑, miR-195↑, miR-199↑, miR-206↑, miR-326-5p↑, Hif1a↓, PI3K↓, cMyc↓, AMPK↑, P53↑, Glycolysis↓, HK2↓, LDHA↓, PKM2↓, PPP↓, G6PD↓, GlutaM↓, GLS↓, miR-21↑, miR-221↑, miR-222↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   G6PD↓, 1,   GLS↓, 1,   GlutaM↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PKM2↓, 1,   PPP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   miR-101↑, 1,   miR-106b↓, 1,   miR-122-5p↑, 1,   miR-126↑, 2,   miR-130a↓, 1,   miR-141↑, 1,   miR-145↑, 1,   miR-15↑, 1,   miR-155↓, 2,   miR-17↓, 2,   miR-195↑, 2,   miR-199↑, 1,   miR-200c↑, 1,   miR-206↑, 2,   miR-21↓, 2,   miR-21↑, 1,   miR-221↓, 3,   miR-221↑, 1,   miR-222↓, 1,   miR-222↑, 1,   miR-25-5p↑, 1,   miR-27a-3p↓, 1,   miR-27a-3p↑, 1,   miR-326-5p↑, 1,   miR-34a↑, 2,   miR-34b-5p↑, 1,   miR-409-3p↑, 1,   miR-429↑, 1,   miR-491↑, 1,   miR-497↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Let-7↑, 2,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

miR-20↓, 1,   MMP2↓, 1,   MMP9↓, 1,   TumPF↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  
Total Targets: 56

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-221, miR-221
1 Bufalin/Huachansu
1 Curcumin
1 Lactobacillus
1 Licorice
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1398  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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