DNMT3B Cancer Research Results

DNMT3B, Maintenance DNA Methyltransferase: Click to Expand ⟱
Source:
Type: oncogenic
DNMT3B 
Often UPREGULATED (mainly solid tumors)
Effect
-Aberrant de novo methylation at non-physiologic loci
-Silencing of differentiation and tumor suppressor genes
-Reinforces epigenetic chaos rather than orderly programming

Classification
-Contextual oncogenic epigenetic amplifier


Scientific Papers found: Click to Expand⟱
9287- BR, BRJ,    Anticancer and Anti-Inflammatory Potential of Betalains: A Systematic Review on Preclinical Studies
- Review, Var, NA
tumCV↓, TumCP↓, Apoptosis↑, Casp↑, TumCCA↑, Inflam↓, NF-kB↓, CCN2/CTGF↓, IL6↓, COX2/PTGS2↓, iNOS↓, toxicity↓, *ROS↓, ROS↑, *SOD↑, *Catalase↑, PI3K↓, Akt↓, mTOR↓, DNMT1↓, DNMT3A↓, DNMT3B↓, HDAC6↓,
7007- Fuc,    The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles
- Review, Var, NA
TumCCA↑, Apoptosis↑, NK cell↑, chemoP↑, TumCG↓, *Inflam↓, *antiOx↑, *AntiThr↑, *AntiViral↑, angioG↓, ChemoSen↑, ROS↑, GSH↓, mtDam↓, MMP↓, DNMT3B↓, TumCG↓, Dose↝, Dose↝, QoL∅, fatigue∅, Dose↝,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, Synergy↑, ChemoSen↑,
7654- IP,    Dietary Supplementation of Inulin Contributes to the Prevention of Estrogen Receptor-Negative Mammary Cancer by Alteration of Gut Microbial Communities and Epigenetic Regulations
- in-vivo, BC, NA
TumCG↓, GutMicro↑, PA↑, HDAC2↓, HDAC8↓, DNMT3B↓, Akt↓, PI3K↓, NF-kB↓, Dose↝, Dose↝,
9180- ITCs,  SFN,    Epigenetics/epigenomics and prevention of early stages of cancer by isothiocyanates Review
- Review, Var, NA
HDAC↓, DNMT1↓, DNMT3B↓, BioAv↑, chemoPv↑, NRF2↑, HO-1↑, NQO1↑, GSK‐3β↓, β-catenin/ZEB1↓, EMT↓, ac‑H3↑, ac‑H4↑, Wnt↓, HDAC3↓, p‑γH2AX↑, hTERT/TERT↓, NA↑, cMyc↓, HDAC2↓, HDAC3↓, KLF4↓, TumVol↓, Dose?,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GSK‐3β↓, 1,   PA↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   Casp↑, 1,   IAP1↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 1,   p‑Akt↓, 1,   MEK↓, 1,   mTOR↓, 2,   PI3K↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMT3B↓, 5,   ac‑H3↑, 1,   ac‑H4↑, 1,   HDAC↓, 1,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC6↓, 1,   HDAC8↓, 1,   KLF4↓, 1,   tumCV↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

hTERT/TERT↓, 2,   P53↑, 1,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 3,   TumCP↓, 2,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

CCN2/CTGF↓, 1,   EMT↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL6↓, 1,   Inflam↓, 1,   MyD88↑, 1,   NF-kB↓, 3,   NK cell↑, 1,   TLR4↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 2,   Dose?, 1,   Dose↝, 5,   MDR1↓, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

hTERT/TERT↓, 2,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   chemoPv↑, 1,   fatigue∅, 1,   QoL∅, 1,   toxicity↓, 1,   TumVol↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 72

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   ROS↓, 1,   SOD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: DNMT3B, Maintenance DNA Methyltransferase
1 Beetroot
1 Fucoidan
1 Genistein (soy isoflavone)
1 Inulin Prebiotic
1 Isothiocyanates
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1409  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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