chemoPv Cancer Research Results

chemoPv, ChemoPreventive: Click to Expand ⟱
Source:
Type:
Chemopreventive: An agent that lowers the probability of cancer development or delays progression from premalignant states.
Mechanisms
-Reduce DNA damage / mutagenesis
-Enhance detoxification or repair
-Modulate hormones or inflammation
-Promote differentiation or apoptosis of abnormal cells


Scientific Papers found: Click to Expand⟱
7981- AAS/EEAA,    Chemopreventive Potential of Oils Extracted from Seeds of Three Annona Species
- Review, Var, NA
other↝, chemoPv↑,
4599- AgNPs,  ProBio,    Impacts of dietary silver nanoparticles and probiotic administration on the microbiota of an in-vitro gut model
- in-vivo, Nor, NA
*GutMicro∅, *chemoPv↑,
5168- AL,    Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells
- in-vitro, Var, NA
TumCG↓, Casp3↑, Casp8↑, Casp9↑, chemoPv↑,
7400- Amla,    Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer
- Review, Var, NA
radioP↑, ChemoSen↑, chemoPv↑, *ROS↓, antiOx↑, Inflam↓, Imm↑, *hepatoP↑, *cardioP↑, *lipid-P↓, TumCCA↑, Chk2↑, CDK1↓, CycB/CCNB1↓, CDC25↓, TumMeta↓,
6595- Anamu,    Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of aryl hydrocarbon receptor
- in-vivo, Nor, NA
CYP1A1↓, CYP1B1↓, chemoPv↑,
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, CompStab↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, Synergy↑, AntiAg↑, Synergy↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2596- Api,  LT,    Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment
- Review, Var, NA
NRF2↓, chemoPv↑, ChemoSen↑,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, CompStab↓, chemoPv↑,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, Synergy↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, ChemoSen↑,
4814- ASTX,    Chemopreventive and therapeutic efficacy of astaxanthin against cancer: A comprehensive review
- Review, Var, NA
Apoptosis↑, EMT↓, AntiCan↑, *cardioP↑, *neuroP↑, TumCG↓, *antiOx↑, *Bacteria↓, *Imm↑, *hepatoP↑, *AntiDiabetic↑, ROS↓, *chemoPv↑,
5427- ASTX,    Astaxanthin and Cancer Chemoprevention
- Review, Var, NA
chemoP↑, AntiCan↑, chemoPv↑, Risk↓, lipid-P↓, Pain↓, BioAv↑, Dose↝,
147- ATG,  EGCG,  CUR,    Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, MCF7
Bax:Bcl2↑, NF-kB↓, PI3K/Akt↓, STAT3↓, chemoPv↑, TumCP↓, TumCCA↑, TumCMig↓,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, Synergy↑, chemoPv↑, BioAv↓,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,
5632- BCA,    Pharmacokinetics and bioavailability of the isoflavone biochanin A in rats
- in-vivo, Var, NA
chemoPv↑, *BioAv↓,
6512- BCP,    Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells
- in-vitro, MM, NA
CB2 / CNR2↑, BAX↑, Bcl-2↓, Casp3↑, TumCP↓, Apoptosis↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Inflam↓, chemoPv↑, neuroP↑, *BioAv↝, CB2 / CNR2↑, tumCV↓,
5582- BetA,    Targeting mitochondrial apoptosis by betulinic acid in human cancers
- Review, Var, NA
Apoptosis↑, MMP↓, Cyt‑c↑, ROS↑, NF-kB↑, angioG↓, mtDam↑, TOP1↓, selectivity↑, ChemoSen↑, TumCG↓, chemoPv↑, RadioS↑,
2736- BetA,  Chemo,    Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis
- Review, Var, NA
chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,
2759- BetA,    Chemopreventive and Chemotherapeutic Potential of Betulin and Betulinic Acid: Mechanistic Insights From In Vitro, In Vivo and Clinical Studies
- Review, Var, NA
chemoPv↑, ChemoSen↑, *Inflam↓, *NRF2↑, *NF-kB↓, *COX2/PTGS2↓, ROS↑, MMP↓, Sp1/3/4↓, VEGF↓,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *Synergy↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, Synergy↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, Synergy↑, MMP1↓, MMP2↓, Synergy↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑, *antiAll↑,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2/PTGS2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
5745- Buty,    Microbial Oncotarget: Bacterial-Produced Butyrate, Chemoprevention and Warburg Effect
- Review, Var, NA
selectivity↑, HDAC↓, TumCP↓, Apoptosis↑, Warburg↓, chemoPv↑,
5751- CA,    Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
- Review, Var, NA
*antiOx↑, *chemoPv↑, ROS↑, MMP2↓, MMP9↓, BioAv↓, eff↑, *Inflam↓, AMPK↑, lipid-P↑, Synergy↑, ChemoSen↑, *memory↑, *ROS↓,
5868- CA,    Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29 - in-vitro, CRC, LoVo
Apoptosis↑, TumCMig↓, uPA↓, MMPs↓, COX2/PTGS2↓, TumCA↓, MMP9↓, MMP2↓, chemoPv↑,
5779- Calc,    Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials
- Study, CRC, NA
chemoPv↑,
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
5833- CAP,    Capsaicin: From Plants to a Cancer-Suppressing Agent
- Review, Var, NA
chemoPv↑, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Ca+2↑, JNK↑, Casp3↑, NADH↓, CDK2↓, CDK4↓, CDK6↓, P53↑,
5861- CAP,    Anticancer Properties of Capsaicin Against Human Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,
5198- CAP,    Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines
- in-vitro, CRC, LoVo - in-vitro, CRC, Colo320
tumCV↓, DNAdam↑, Apoptosis↑, ROS↑, MMP↑, Casp3↑, chemoPv↑,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
5772- CAPE,    The Pluripotent Activities of Caffeic Acid Phenethyl Ester
- Review, Var, NA
*Bacteria↓, *AntiCan↑, *Imm↑, *Wound Healing↑, *NF-kB↓, *5LO↓, *AntiDiabetic↑, ChemoSen↑, selectivity↑, chemoPv↑,
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
5926- CAR,    An Updated Review of Research into Carvacrol and Its Biological Activities
- Review, Nor, NA - Review, AD, NA - Review, Asthma, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *toxicity↓, *Pain↓, *TRPV3↑, *NRF2↑, *Ca+2↑, *ATP↑, *5LO↓, *COX2/PTGS2↓, PGE2↓, *hepatoP↑, *AntiAg↑, *Diar↓, *cardioP↑, *other↝, *chemoPv↑, *cognitive↑, *AChE↓, *GastroP↑, *Synergy↑, *BChE↓, *CRP↓, *antiAll↑,
5959- CEL,    Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NF-κB as a possible target
- in-vitro, Cerv, HeLa
Apoptosis↑, Casp8↑, Casp9↑, cl‑BID↑, MMP↓, NF-kB↑, Dose⇅, chemoPv⇅, COX2/PTGS2↓,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2/PTGS2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
6016- CGA,    Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
antiOx↑, *Bacteria↓, AntiCan↑, *Inflam↓, *cardioP↑, *AntiDiabetic↑, *GutMicro↑, *eff↑, *eff↑, *ROS↓, *IronCh↑, *neuroP↑, *AChE↓, *BChE↓, *chemoPv↑, *BioAv⇅,
6072- CHL,    Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
- in-vivo, Var, NA
AntiCan↑, AntiTum↑, chemoPv↑,
6078- CHL,    Update on the bioavailability and chemopreventative mechanisms of dietary chlorophyll derivatives
- Review, Nor, NA
*BioAv↑, chemoPv↑, *ROS↓, eff↑,
6065- CHL,    Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin
- Review, HCC, NA
*eff↑, *chemoPv↑, *other↝,
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
6084- CHOC,    Cocoa Polyphenols and Their Potential Benefits for Human Health
- Review, Nor, NA - Review, Stroke, NA - Review, IBD, NA
*lipid-P↓, *ROS↓, *Inflam↓, *BP↓, *cardioP↑, *chemoPv↑, *BioAv⇅, *antiOx↑, *Risk↓, *5LO↓, *AntiAg↑, *Imm↑, *NF-kB↓, *other↓, CYP1A1↓, COX2/PTGS2↓, *Obesity↓, *cognitive↑,
6085- CHOC,    Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model
- in-vivo, PC, NA
selectivity↑, TumCP↓, p‑Akt↓, NF-kB↓, TumCG↓, *BioAv↑, *chemoPv↑,
6126- CHr,    Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
- in-vitro, Melanoma, NA
tumCV↓, selectivity↑, MPT↑, Cyt‑c↑, Casp3↑, Casp9↑, Apoptosis↑, mtDam↑, chemoPv↑,
2796- CHr,    Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice
- in-vivo, Lung, NA
PCNA↓, COX2/PTGS2↓, NF-kB↓, chemoPv↑, *SOD↑, *Catalase↓, *GR↓, *GPx↓, *lipid-P↓, *COX2/PTGS2↓, *NF-kB↓, *ROS↓,
2799- CHr,    Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-κB
- in-vivo, RCC, NA
*chemoPv↑, *ROS↓, *Inflam↓,

Showing Research Papers: 1 to 50 of 172
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 172

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↓, 1,   Catalase↑, 2,   Fenton↑, 1,   GCLM↑, 1,   GPx↓, 1,   GSH↓, 8,   GSH↑, 3,   GSH/GSSG↓, 2,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 2,   H2O2↓, 1,   H2O2↑, 1,   HO-1↑, 2,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↑, 1,   NADH↓, 1,   NOX↓, 1,   NQO1↑, 4,   Nrf1↑, 2,   NRF2↓, 4,   NRF2↑, 4,   Prx↓, 2,   ox-PrxI↑, 1,   RNS↑, 1,   ROS↓, 7,   ROS↑, 42,   ROS⇅, 2,   mt-ROS↑, 3,   selenoP↑, 1,   SOD↓, 2,   SOD↑, 2,   SOD2↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Mets↑, 1,   Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR↓, 1,   CDC16↓, 1,   CDC25↓, 1,   compI↓, 2,   ETC↓, 1,   mitResp↓, 2,   mitResp↑, 1,   mtDam↑, 4,   OCR↓, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↑, 10,   ATP↓, 2,   FASN↓, 2,   glucose↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 4,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   HK2↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   NADPH↑, 2,   PDK1 / PDPK1↓, 1,   PKM2↓, 1,   SCFAs↑, 1,   SIRT1↓, 2,   SIRT1↑, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 3,   Apoptosis↓, 1,   Apoptosis↑, 63,   BAD↓, 1,   Bak↑, 1,   BAX↑, 18,   Bax:Bcl2↑, 10,   Bcl-2↓, 20,   Bcl-xL↓, 3,   BID↑, 3,   cl‑BID↑, 1,   Casp↑, 5,   cl‑Casp↑, 1,   Casp12↑, 2,   Casp3↑, 30,   cl‑Casp3↑, 4,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 9,   cl‑Casp8↑, 1,   Casp9↑, 17,   cl‑Casp9↑, 3,   cFLIP↓, 1,   Cyt‑c↑, 23,   Diablo↑, 1,   DR5↑, 5,   FADD↑, 3,   Fap1↓, 1,   Fas↑, 1,   FasL↑, 3,   IAP1↓, 1,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 4,   Mcl-1↓, 6,   Mcl-1↑, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p38↑, 3,   p‑p38↓, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 9,   TRAIL↑, 1,   TumCD↑, 4,   XIAP↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 30,   Akt↑, 1,   p‑Akt↓, 7,   AKT1↓, 1,   AMPKα↓, 1,   CDC7↓, 1,   CK2↓, 3,   cMET↓, 1,   EGFR↓, 8,   ERK↓, 7,   p‑ERK↓, 5,   FOXD3↑, 1,   HER2/EBBR2↓, 3,   Hippo↑, 1,   Hippo↝, 1,   IGF-2R↑, 1,   IKKα↓, 3,   IκB↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 3,   JNK↓, 1,   JNK↑, 7,   p‑JNK↓, 2,   MAPK↓, 6,   MAPK↑, 1,   mTOR↓, 12,   P70S6K↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 23,   PI3K/Akt↓, 2,   PRAS40↓, 1,   PTEN↑, 6,   RAS↓, 2,   Sp1/3/4↓, 4,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 16,   p‑STAT3↓, 4,   p‑STAT3↑, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

CBP↑, 1,   cJun↓, 1,   cJun↑, 1,   cMyc↓, 4,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO3↓, 1,   FOXO3↑, 3,   HDAC↓, 7,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 2,   HDAC8↓, 2,   HOTAIR↓, 1,   miR-106b↓, 2,   miR-10a-5p↝, 1,   miR-143↑, 1,   miR-148a↓, 1,   miR-155↝, 1,   miR-194↑, 1,   miR-19b↓, 2,   miR-200b↑, 2,   miR-21↓, 3,   miR-27a-3p↓, 1,   miR-29b↓, 1,   miR-34a↑, 3,   miR-34a↝, 1,   MYCN↓, 1,   OCT4↓, 1,   other↓, 2,   other↑, 1,   other↝, 2,   SOX4↓, 1,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 3,   ER Stress↑, 10,   GRP78/BiP↑, 3,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   HSP90↑, 1,   HSPs↓, 1,   IRE1↑, 2,   NQO2↑, 1,   PDI↑, 1,   PERK↑, 1,   UPR↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 5,   ATG7↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 4,   LC3II↑, 4,   p62↑, 2,   TumAuto↑, 9,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   CUL4B↑, 1,   DNAdam↑, 7,   DNArepair↓, 1,   hTERT/TERT↓, 2,   MSH2↑, 1,   NKX3.1↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 17,   p53 Wildtype↓, 2,   PARP↑, 1,   cl‑PARP↑, 14,   PCNA↓, 7,   Telomerase↓, 3,   TOP1↓, 2,   TOP2↓, 1,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 7,   CDK4↓, 8,   CDK4/6↓, 1,   CDK6↓, 5,   cellSen↑, 1,   Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 18,   CycD3↓, 1,   cycE/CCNE↓, 5,   cycF↓, 1,   E2Fs↓, 1,   Ki-67↓, 5,   P21↓, 2,   P21↑, 10,   p27/CDKN1B↑, 4,   pRB↑, 1,   p‑pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   Securin↓, 1,   TumCCA↑, 38,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   BMP2↓, 1,   CD133↓, 1,   CSCs↓, 6,   Diff↑, 2,   EP300↑, 1,   FGF↓, 1,   Gli↓, 1,   Gli1↓, 4,   HH↓, 3,   IGF-1↓, 4,   IGF-1↑, 1,   IGFBP1↑, 1,   IGFBP3↑, 1,   Ki-67↓, 5,   Let-7↑, 1,   mTORC1↓, 1,   NF2↑, 1,   NOTCH↓, 2,   NOTCH3↓, 1,   PTCH1↓, 2,   SCF↓, 2,   Shh↓, 3,   Smo↓, 2,   TumCG↓, 23,   TumCP↓, 35,   TumCP↑, 1,   Wnt↓, 11,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 3,   Ca+2↓, 1,   Ca+2↑, 11,   i-Ca+2?, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   E-cadherin↑, 6,   EMT↓, 13,   FAK↓, 4,   p‑FAK↓, 2,   GLI2↓, 2,   ITGB4↓, 1,   MET↑, 1,   MMP1↓, 2,   MMP2↓, 16,   MMP7↓, 1,   MMP9↓, 20,   MMPs↓, 7,   MUC4↓, 3,   N-cadherin↓, 7,   PDGF↓, 3,   Rac1↓, 1,   Rho↝, 1,   Slug↓, 2,   Snail↓, 4,   TIMP1↑, 2,   TIMP2↑, 3,   TSC1↑, 1,   TumCA↓, 1,   TumCI↓, 18,   TumCMig↓, 16,   TumMeta↓, 18,   TumMeta↑, 2,   Twist↓, 3,   uPA↓, 6,   Vim↓, 4,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 19,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 29,   CD31/PECAM-1↓, 1,   HIF-1↓, 1,   Hif1a↓, 16,   Hif1a↑, 1,   NO↝, 1,   PGI2↓, 1,   VEGF↓, 20,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 2,   GLUT1↓, 3,   GLUT4↓, 1,   MMP↓, 23,   MMP↑, 2,   MPT↑, 3,   TRPV1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CD44↓, 1,   cDC2↓, 1,   COX2/PTGS2↓, 24,   CXCL12↓, 1,   CXCR2↓, 2,   CXCR4↓, 5,   DR4↑, 3,   HMGB1↓, 1,   ICAM-1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL1α↓, 1,   IL1β↓, 3,   IL6↓, 6,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 11,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 30,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NLRP3↓, 1,   NLRP3↑, 1,   p‑p65↓, 1,   PD-L1↓, 1,   PGE2↓, 8,   PSA↓, 7,   RAGE↓, 1,   TCF↓, 1,   TLR4↝, 1,   TNF-α↓, 6,   TNF-α↑, 2,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PRNP↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 3,   ACE/ACE1↓, 1,   AR↓, 7,   AR↝, 2,   AR-V7?, 1,   COMT↓, 2,   CYP19?, 1,   ER-α36↝, 1,   ER(estro)↓, 1,   Estro↝, 1,   PPARα↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 8,   BioAv↑, 12,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 35,   ChemoSen∅, 1,   CompStab↓, 2,   CompStab↑, 1,   CYP1A1↓, 3,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP1B1↓, 1,   CYP3A4↓, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 17,   eff?, 1,   eff↓, 5,   eff↑, 14,   eff↝, 4,   GSTA1↓, 1,   Half-Life↓, 1,   Half-Life↝, 3,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 3,   P-gp/ABCB1⇅, 1,   P450↓, 1,   RadioS↑, 12,   selectivity?, 1,   selectivity↑, 22,   Synergy↑, 15,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 7,   AR↝, 2,   ascitic↓, 1,   AST↓, 1,   BRCA1↑, 1,   creat↓, 1,   EGFR↓, 8,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 2,   IL6↓, 6,   LDH↓, 1,   PD-L1↓, 1,   PSA↓, 7,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 24,   AntiDiabetic↑, 1,   antiNeop↑, 1,   AntiTum↑, 5,   cardioP↑, 2,   chemoP↑, 6,   chemoPv↑, 138,   chemoPv⇅, 1,   ChemoSideEff↓, 1,   hepatoP↑, 4,   mal↓, 1,   memory↑, 1,   Nausea↓, 1,   neuroP↑, 5,   OS↑, 1,   Pain↓, 1,   QoL↑, 2,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 10,   TGFβR1↑, 1,   toxicity↓, 6,   toxicity↝, 3,   TumVol↓, 4,   TumW↓, 1,   Vomit↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 477

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 27,   Catalase↓, 1,   Catalase↑, 3,   GPx↓, 1,   GPx↑, 3,   GSH↑, 9,   GSTs↑, 3,   HO-1↑, 2,   lipid-P↓, 5,   MDA↓, 3,   NQO1↑, 2,   NRF2↑, 7,   RNS↓, 2,   ROS?, 2,   ROS↓, 30,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 4,   TrxR↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 5,   ALAT↓, 1,   AMPK↑, 2,   ATP↑, 1,   ATP↝, 1,   glucose↓, 1,   LDL↓, 1,   lipidLev↓, 1,   NAD↝, 1,   NADPH↑, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,   Casp3∅, 1,   Casp9↓, 1,   Cyt‑c∅, 1,   iNOS↓, 3,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 1,   p‑CREB↑, 1,   ERK↑, 1,   JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   PKCδ↓, 1,   RAS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 2,   other↝, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 6,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 2,   EMT↓, 1,   MMP9↓, 1,   serineP↓, 1,   TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   MMP∅, 2,   TRPV1↑, 1,   TRPV3↑, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 9,   IL18↓, 1,   IL1β↓, 3,   IL2↑, 1,   IL4↑, 1,   IL6↓, 3,   IL8↓, 1,   Imm↑, 5,   Inflam↓, 34,   Inflam↑, 1,   NF-kB↓, 10,   PGE2↓, 1,   TNF-α↓, 7,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 2,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↓, 1,   PPARα↑, 1,   p‑PPARγ↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 10,   BioAv⇅, 2,   BioAv↝, 10,   CompStab↝, 1,   CYP2E1↓, 1,   Dose↓, 1,   Dose↑, 3,   Dose↝, 7,   eff↑, 9,   GSTA1↑, 1,   Half-Life?, 1,   Half-Life↓, 1,   Half-Life↝, 4,   selectivity↑, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   BMD↑, 1,   BP↓, 2,   Calcium↑, 1,   CRP↓, 1,   hs-CRP↓, 1,   IL6↓, 3,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 3,   AntiCan↓, 1,   AntiCan↑, 3,   AntiDiabetic↓, 1,   AntiDiabetic↑, 10,   cardioP↑, 8,   cardioP⇅, 1,   chemoP↑, 2,   chemoPv↑, 34,   ChemoSideEff↓, 1,   cognitive↑, 3,   hepatoP↑, 10,   memory↑, 4,   neuroP↑, 11,   Obesity↓, 2,   OS↑, 1,   Pain↓, 3,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,   Stroke↓, 1,   toxicity↓, 8,   toxicity↝, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   Bacteria↓, 6,   Diar↓, 1,   GutMicro↑, 1,   GutMicro∅, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 153

Scientific Paper Hit Count for: chemoPv, ChemoPreventive
8 Curcumin
7 Phenethyl isothiocyanate
6 Chemotherapy
6 Capsaicin
6 Chrysin
6 Resveratrol
6 Quercetin
6 Sulforaphane (mainly Broccoli)
4 Apigenin (mainly Parsley)
4 Diindolylmethane
4 Indole-3-carbinol
4 D-limonene
4 Fisetin
4 Nimbolide
4 Thymoquinone
3 EGCG (Epigallocatechin Gallate)
3 Betulinic acid
3 Chlorophyllin
3 Chocolate
3 α-Santalol/Sandalwood oil
2 Astaxanthin
2 Arctigenin
2 Biochanin A
2 Carvacrol
2 Celecoxib
2 Cucurbitacin
2 methylseleninic acid
2 Genistein (soy isoflavone)
2 Eugenol
2 Formononetin
2 Grapeseed extract
2 Hibiscus sabdariffa
2 Inositol
2 phytic acid, Inositol hexakisphosphate
2 Isovitexin
2 Vitexin
2 Licochalcone A
1 Annona atemoya Seed Extract
1 Silver-NanoParticles
1 probiotics
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Luteolin
1 Ashwagandha(Withaferin A)
1 Berberine
1 Beta-Caryophyllene
1 Boron
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Calcium
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Chlorogenic acid
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Crocetin
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Deguelin
1 Diclofenac
1 Dandelion Root
1 Ginkgo biloba-EGb 761
1 5-fluorouracil
1 Garcinol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Honokiol
1 Hops (Humulus lupulus)
1 Hyperoside
1 Inulin Prebiotic
1 Isoliquiritigenin
1 isoflavones
1 Juglone
1 Kaempferol
1 Lasiodin
1 SDG/lignans
1 Magnolol
1 mebendazole
1 Sulindac
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 Lemon Balm/Melissa officinalis
1 Moringa oleifera
1 Morin
1 Oleuropein
1 Psoralidin
1 Rutin
1 buckwheat sprouts
1 Selenium
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Selenite (Sodium)
1 Sutherlandioside D
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1417  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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