HOMA Cancer Research Results

HOMA, HOMA-IR (Homeostatic Model Assessment of Insulin Resistance): Click to Expand ⟱
Source:
Type:
HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a surrogate index of:
-Insulin resistance
-Compensatory hyperinsulinemia
Functionally, a high HOMA-IR indicates chronic activation of insulin–IGF signaling, which is directly oncogenic.
HOMA-IR < 1.0: Low oncogenic insulin signaling
HOMA-IR 1.5–2.5: Mild risk amplification
HOMA-IR > 2.5–3.0: Sustained oncogenic signaling environment

Reducing HOMA-IR downregulates oncogenic signaling:
-Caloric restriction / fasting
-Exercise (↑ insulin sensitivity, ↑ irisin)
-AMPK activation (e.g., metformin)
-Weight reduction (↓ leptin, ↓ resistin

A high HOMA-IR reflects a pro-cancer signaling state, characterized by:
-PI3K–AKT–mTOR hyperactivation
-Loss of metabolic checkpoints
-Inflammation–hormone synergy


Scientific Papers found: Click to Expand⟱
5061- Ex,    Role of physical exercise in modulating the insulin-like growth factor system for improving breast cancer outcomes: A meta-analysis
- Review, BC, NA
IGF-2↓, IGFBP1↓, HOMA↓, glucose∅, IGF-1∅, eff↑,
8586- FS,    The Role of Flaxseed in Improving Human Health
- Review, Nor, NA
*lipidLev↓, *BP↓, *HOMA↓, *AntiCan↑, *antiOx↑, *BioAv↑, *Ingr↑, *Ingr↝, *Ingr↝, *GutMicro↑, *CompStab↝, *TC↓, *TG/TAG↓, *LDL↓, *HDL↑, *BP↓, *AntiDiabetic↑, *AntiCan↑, TumCD↑, selectivity↑, TumCP↓, Apoptosis↑, DNAdam↑, i-ROS↑, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, ChemoSen↑, Synergy↑, *Inflam↓, *hs-CRP↓, *VCAM-1↓, *BDNF↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

i-ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose∅, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   TumCD↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1∅, 1,   IGF-2↓, 1,   IGFBP1↓, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↑, 1,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

HOMA↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HDL↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,   lipidLev↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VCAM-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   CompStab↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 2,   HOMA↓, 1,   hs-CRP↓, 1,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 2,  
Total Targets: 19

Scientific Paper Hit Count for: HOMA, HOMA-IR (Homeostatic Model Assessment of Insulin Resistance)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1425  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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