MOMP Cancer Research Results

MOMP, Mitochondrial Outer Membrane Permeabilization: Click to Expand ⟱
Source:
Type:
MOMP is the point-of-no-return decision step of intrinsic apoptosis. It is the event in which the mitochondrial outer membrane becomes permeable, allowing release of pro-death factors that irreversibly commit a cell to die. Cancer progression is characterized by systematic suppression, buffering, or decoupling of MOMP from lethal execution.

MOMP occurs when BAX and/or BAK oligomerize in the mitochondrial outer membrane, forming pores that release:
-Cytochrome c → apoptosome → caspase-9
-Smac/DIABLO → IAP neutralization
-Other apoptogenic factors (e.g., Omi/HtrA2)
Once sufficient mitochondria undergo MOMP, cell death is inevitable (even if caspases are later inhibited).
Redox, Metabolism, and MOMP (Critical)
-High xCT / GSH → suppress mitochondrial ROS → MOMP ↓
-Autophagic flux → removes damaged mitochondria → MOMP ↓
-Pro-oxidant overload → mitochondrial dysfunction → MOMP ↑


Scientific Papers found: Click to Expand⟱
5130- ART/DHA,    Dihydroartemisinin Induces Apoptosis in Human Bladder Cancer Cell Lines Through Reactive Oxygen Species, Mitochondrial Membrane Potential, and Cytochrome C Pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, eff↓, Apoptosis↑, Casp3↑, ROS↑, Cyt‑c↑, MMP↓, Bcl-2↓, BAX↑, MOMP↑, TumCG↓,
5378- ART/DHA,    Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives
- Review, Var, NA
Ferroptosis↑, Iron↑, lipid-P↑, MOMP↑, AntiCan↑, NCOA4↑, GSH↓, GPx4↓, ROS↑, ChemoSen↑, ER Stress↑, DNAdam↑, angioG↓, TumCCA↑, eff↓,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP/DDIT3↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
6543- BSB,    alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells
- in-vitro, GBM, U87MG
tumCV↓, selectivity↑, TumCD↑, Apoptosis↑, MOMP↓, Cyt‑c↑, cl‑PARP↑,
6236- CUSP9,  EP,    Tumor Treating Fields (TTFields) combined with the drug repurposing approach CUSP9v3 induce metabolic reprogramming and synergistic anti-glioblastoma activity in vitro
- in-vitro, GBM, U251
Apoptosis↑, MOMP↓, Casp2↑, Bcl-2↓, Mcl-1↓, eff↑, OCR↓, OXPHOS↓, TumCMig↓,
6350- DRE,    Tracking Evidences of Dandelion for the Treatment of Cancer: From Chemical Composition, Bioactivity, Signaling Pathways in Cancer Cells to Perspective Study
- Review, Var, NA
AntiCan↑, *Bacteria↓, *Inflam↓, *antiOx↑, TumCCA↑, Apoptosis↑, MOMP↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, MMP↓, Bcl-2↓, TumCMig↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓, TumAuto↑, mTOR↓, 4E-BP1↓, Glycolysis↓, angioG↓,
6367- DRE,    Antioxidant and antimicrobial activities of Dandelion root extract (Taraxacum officinale) and its cytotoxic effect on MDA-MB-231 breast cancer cells
- in-vitro, BC, MDA-MB-231
TumCD↑, *antiOx↑, *ROS↓, tumCV↓, Apoptosis↑, ROS↑, TumCCA↑, MOMP↑, ROS↑,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
5519- EP,    Nanosecond Pulsed Electric Fields (nsPEFs) for Precision Intracellular Oncotherapy: Recent Advances and Emerging Directions
- Review, Var, NA
MMP↓, Ca+2↑, eff↑, ER Stress↑, selectivity↑, CSCs↓, CD44↓, CD133↓, ROS↑, Imm↑, DNAdam↑, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp9↑, TumCD↑, Fas↑, UPR↑, Dose↝, Dose↝, Dose↓, Dose↑, HMGB1↓, eff↑, EPR↑, ChemoSen↑, ETC↝, *AntiAge↑, *Hif1a↑, *SIRT1↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
5125- Sal,    Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
- in-vitro, GBM, NA
ER Stress↑, UPR↑, autoF↓, lysosome↝, ROS↑, lipid-P↑, CSCs↓, necrosis↑, ATP↓, MMP↓, MOMP↑, DNAdam↑, AIF↑, lysoMP↑, MitoP↑, Ca+2↑,

Showing Research Papers: 1 to 12 of 12

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 2,   GPx4↓, 2,   GSH↓, 1,   HO-1↓, 1,   Iron↑, 1,   lipid-P↑, 3,   MDA↑, 1,   NRF2↓, 1,   OXPHOS↓, 1,   ROS↑, 10,   xCT↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

NCOA4↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 1,   ETC↝, 1,   MMP↓, 5,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CYP3A4↓, 1,   Glycolysis↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 8,   BAX↑, 4,   Bcl-2↓, 6,   Bcl-xL↓, 1,   BID↑, 1,   Casp↑, 1,   cl‑Casp↑, 1,   Casp2↑, 1,   Casp3↑, 5,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↑, 8,   DR4↑, 1,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 2,   lysoMP↑, 1,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 1,   MOMP↓, 3,   MOMP↑, 9,   necrosis↑, 1,   survivin↓, 1,   TumCD↑, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 4,   GRP78/BiP?, 1,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

autoF↓, 1,   lysosome↝, 1,   MitoP↑, 1,   SESN2↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 4,   P53↑, 2,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   CD133↓, 1,   CD44↓, 1,   CSCs↓, 2,   GSK‐3β↑, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 2,   TumCG↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   FAK↓, 1,   MMP2↓, 2,   MMP9↓, 2,   TIMP2↑, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 2,   TumMeta↑, 1,   uPA↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   EPR↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CXCR2↓, 1,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   Imm↑, 2,   JAK2↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 4,   Dose↓, 1,   Dose↑, 1,   Dose↝, 4,   eff↓, 2,   eff↑, 4,   RadioS↑, 1,   selectivity↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   toxicity↓, 1,  
Total Targets: 115

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

diuretic↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   SIRT1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 3,   JAK↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   toxicity↑, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 21

Scientific Paper Hit Count for: MOMP, Mitochondrial Outer Membrane Permeabilization
2 Artemisinin
2 Electrical Pulses
2 Dandelion Root
1 Betulinic acid
1 α-Bisabolol / Chamomile oil
1 CUSP9
1 Emodin
1 Ginkgetin
1 Nimbolide
1 salinomycin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1434  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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