TRF2 Cancer Research Results

TRF2, Telomeric Repeat–Binding Factor 2: Click to Expand ⟱
Source:
Type:
TRF2 is a core component of the shelterin complex that caps telomeres and prevents chromosome ends from being recognized as DNA double-strand breaks. In cancer, TRF2 is frequently overexpressed or functionally reprogrammed, enabling unlimited proliferation while suppressing lethal DNA damage responses.
TRF2 Status in Cancer
-Upregulated in many solid tumors (breast, lung, colorectal, glioma, melanoma)
-High TRF2 correlates with:
  -Advanced stage
  -Genomic instability tolerance
  -Poor prognosis
-Often elevated independently of telomerase (TERT)

TRF2 vs Telomerase
| Feature                  | TRF2               | Telomerase (TERT) |
| ------------------------ | ------------------ | ----------------- |
| Function                 | Protects telomeres | Extends telomeres |
| Cancer role              | Hides damage       | Restores length   |
| Required for immortality | Often yes          | Often yes         |
| Can substitute partially | ✔                  | ✔                 |


Scientific Papers found: Click to Expand⟱
347- AgNPs,    The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?
- Review, Var, NA
ROS↑, TumCCA↑, ER Stress↑, TumCG↓, TumCP↓, DNAdam↑, P53↑, MMP2↓, MMP9↓, angioG↓, TumMeta↓, MMP↓, Casp3↑, cycD1/CCND1↓, PCNA↓, TNF-α↓, IL6↓, P21↑, p27/CDKN1B↑, CDK2↓, CDK4↓, Fas↑, FADD↑, BAX↑, PUMA↑, Bcl-2↓, Bcl-xL↓, ATP↓, PDK1 / PDPK1↓, Glycolysis↓, Cyt‑c↑, cl‑PARP↑, TRF2↓, hTERT/TERT↓, ETC↓, GSH↓, eff↑, ChemoSen↑, EMT↓,
5137- ART/DHA,    Autophagy-dependent cell cycle arrest in esophageal cancer cells exposed to dihydroartemisinin
- vitro+vivo, ESCC, Eca109
tumCV↓, TumCCA↑, ROS↑, TumAuto↑, eff↓, TRF2↓, TumCP↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 1,   Glycolysis↓, 1,   PDK1 / PDPK1↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   Cyt‑c↑, 1,   FADD↑, 1,   Fas↑, 1,   PUMA↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   hTERT/TERT↓, 1,   P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,   TRF2↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   p27/CDKN1B↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

EMT↓, 1,   MMP2↓, 1,   MMP9↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↓, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

hTERT/TERT↓, 1,   IL6↓, 1,  
Total Targets: 44

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TRF2, Telomeric Repeat–Binding Factor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1435  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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