Na+ Cancer Research Results

Na+, Sodium ion: Click to Expand ⟱
Source:
Type:
Na+, Sodium Ion -Na⁺ influx enhances metastatic potential.
-VGSC activation → Na⁺ influx
-Na⁺ entry alters cell membrane potential.(Vm)
-in cancer: VGSC expression: ↑ upregulated
-in cancer: Na⁺ influx: ↑ increased
Na⁺ gradients support several transporters:
Transporter	             Effect
Na⁺/H⁺ exchanger (NHE1)	     extracellular acidification
Na⁺/Ca²⁺ exchanger	     Ca²⁺ signaling
Na⁺/glucose cotransporter    metabolic adaptation
-Sodium channel blockers can reduce metastasis in models.
Scientific Papers found: Click to Expand⟱
5859- CAP,    Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
- Review, Var, NA
*TRPV1↑, *Ca+2↑, *Na+↑, *UCPs↑, *SIRT1↑, *PPARγ↑, *Inflam↓, *lipid-P↑, *IL6↓, *TNF-α↓, *NF-kB↓, *p‑Akt↑, *NRF2↑, *HO-1↑, *ROS↑, *GutMicro↑,
8322- LIN,  doxoR,    Effect of linalool as a component of Humulus lupulus on doxorubicin-induced antitumor activity
- vitro+vivo, Var, NA
ChemoSen↑, TumW↓, Na+↝,
7387- MF,    Effects of Sinusoidal Magnetic Field Observed on Cell Proliferation, Ion Concentration, and Osmolarity in Two Human Cancer Cell Lines
- in-vitro, AML, HL-60 - in-vitro, adrenal, SK-HEP-1
Dose↝, TumCG↓, Na+↑, K+↑,
5535- MFrot,    Spatiotemporal magnetic fields enhance cytosolic Ca2+ levels and induce actin polymerization via activation of voltage-gated sodium channels in skeletal muscle cells
- in-vitro, Nor, NA
*Dose↝, *Vm/CMP↑, *Na+↑, *VGSC↑, *Vm/CMP↑,
5608- NaHCO3,    Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism
- Study, Var, NA
TumCG↓, TumMeta↓, e-pH↑, Pyro↑, Imm↑, Na+↑,
8442- OM,    Marjoram Extract Modulates Ion Currents, Intracellular Calcium Signaling, and MTT-Reducing Activity in Bovine Chromaffin Cells and Rat Cortical Neurons
- in-vitro, Nor, NA
*Ca+2↝, *Na+↝,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Pyro↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 2,  

Migration(tgid=13) ⓘ

Na+↑, 2,   Na+↝, 1,   TumMeta↓, 1,  

Barriers & Transport(tgid=15) ⓘ

K+↑, 1,   Na+↑, 2,   Na+↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

TumW↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   lipid-P↑, 1,   NRF2↑, 1,   ROS↑, 1,   UCPs↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SIRT1↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   Ca+2↝, 1,   Na+↑, 2,   Na+↝, 1,  

Barriers & Transport(tgid=15) ⓘ

Na+↑, 2,   Na+↝, 1,   TRPV1↑, 1,   VGSC↑, 1,   Vm/CMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 24

Scientific Paper Hit Count for: Na+, Sodium ion
1 Capsaicin
1 Linalool
1 doxorubicin
1 Magnetic Fields
1 Magnetic Field Rotating
1 Bicarbonate(Sodium)
1 Marjoram (Origanum majorana)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1452  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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