BRD4 Cancer Research Results

BRD4, BRD4: Click to Expand ⟱
Source:
Type:
BRD4 (Bromodomain-containing protein 4) is a BET epigenetic reader that binds acetylated histones, organizes enhancer/super-enhancer transcriptional programs, and promotes transcriptional elongation of growth and survival genes such as MYC. In cancer it is generally pro-oncogenic, supporting proliferation, cell-state maintenance, and therapy resistance.
Scientific Papers found: Click to Expand⟱
5541- BBM,    Berbamine Suppresses the Growth of Gastric Cancer Cells by Inactivating the BRD4/c-MYC Signaling Pathway
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
TumCP↓, TumCCA↑, Apoptosis↑, BRD4↓, selectivity↑, TumCG↓, cMyc↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

BRD4↓, 1,  

Cell Cycle & Senescence ⓘ

BRD4↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: BRD4, BRD4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1454  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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