Dectin1 Cancer Research Results

Dectin1, Dectin-1 (CLEC7A): Click to Expand ⟱
Source:
Type:
Dectin-1>/b> is a C-type lectin pattern-recognition receptor, best known as a receptor for β-glucans from fungal cell walls. In cancer, it matters because it sits at the interface of innate immunity, myeloid-cell signaling, fungal/mycobiome sensing, and tumor microenvironment control. Its downstream signaling commonly involves SYK, CARD9, NF-κB, MAPK, and cytokine programs.
There are two broad oncology strategies being discussed:
-Activate Dectin-1 to enhance innate/adaptive anti-tumor immunity, often using β-glucan-based adjuvant approaches or combination immunotherapy.
-Block Dectin-1 in tumors where it is driving suppressive macrophage biology and poor T-cell function. This is why recent reviews call Dectin-1 a dual-role target rather than a universally targetable pathway in one direction.
Scientific Papers found: Click to Expand⟱
5570- B-Gluc,    Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1
- Review, Var, NA
Imm↑, BioAv↝, eff↑, AntiCan↑, Dectin1↝, Dose↝, BioAv↓,
5573- B-Gluc,    Continuous Exposure to Non-Soluble β-Glucans Induces Trained Immunity in M-CSF-Differentiated Macrophages
- in-vitro, Nor, NA
*Dectin1↑, *Imm↑, *TNF-α↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Immune & Inflammatory Signaling ⓘ

Dectin1↝, 1,   Imm↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↝, 1,   Dose↝, 1,   eff↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  

Infection & Microbiome ⓘ

Dectin1↝, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling ⓘ

Dectin1↑, 1,   Imm↑, 1,   TNF-α↓, 1,  

Infection & Microbiome ⓘ

Dectin1↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: Dectin1, Dectin-1 (CLEC7A)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1455  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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