OCLN Cancer Research Results

OCLN, Occludin: Click to Expand ⟱
Source:
Type:
Occludin 
Target/Pathway: Occludin
Abbreviation: OCLN
Category: Tight junction / intestinal barrier
Direction in IBD: usually down
Cancer relevance: usually barrier-loss associated, especially in inflammation-linked colorectal cancer


Scientific Papers found: Click to Expand⟱
5932- CAR,    Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
- in-vivo, IBD, NA - in-vivo, Park, NA
*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2/PTGS2↓, *IFN-γ↓, IL1β↓, ADAM10?,
6011- CGA,    Chlorogenic Acid’s Role in Metabolic Health: Mechanisms and Therapeutic Potential
- Review, Nor, NA
*BioAv↓, *antiOx↑, *Inflam↓, *Bacteria↓, *hepatoP↑, *cardioP↑, *neuroP↑, *ROS↓, *NF-kB↓, *NRF2↑, *Obesity↓, *GutMicro↑, *AntiAg↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *OCLN↓, *VEGF↓, BioAv↝,
7429- CS,    Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
- Review, Nor, NA - Review, IBD, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *ICAM-1↓, *IL1β↓, *IL6↓, *MUC1↑, *OCLN↑, *IBI↑, *ROS↓, *cardioP↑, *SOD↑, *GPx↑, *GSH↑, *TG/TAG↓, *LDL↓, *neuroP↑, *5HT↑, *BDNF↑,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
7006- Fuc,    Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug—A Review
- Review, Var, NA
*toxicity↓, *AntiViral↑, *antiOx↑, *Imm⇅, AntiCan↑, TumCCA↑, Apoptosis↑, TumMeta↓, angioG↓, antiNeop↑, VEGF↓, MMPs↓, BioAv↑, BioAv↑, ROS⇅, cl‑PARP↑, Casp3↑, Casp7↑, ROS↑, GSH↓, MMP↓, PI3K↓, ERK↓, MAPK↑, TumCP↓, Bax:Bcl2↑, TJ↑, ZO-1↑, OCLN↑, CLDN1↑, IBI↑, GutMicro↑, NK cell↑, STAT3↓, eff↑,
7035- GA,    Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF-κB/MAPK signaling pathway
- in-vitro, IBD, Caco-2
*Inflam↓, *antiOx↑, *CLDN1↓, *OCLN↓, *ZO-1↓, *IL6↓, *IL1β↓, *TNF-α↓, *BAX↓, *BAD↓, *Casp3↓, *Casp8↓, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *TJ↑, *Apoptosis↓, *NF-kB↓, *MAPK↓,
7557- HYP,    Hyperoside protects the blood-brain barrier from neurotoxicity of amyloid beta 1-42
- in-vitro, AD, NA
*neuroP↑, *Aβ↓, *Casp3↑, *ZO-1↓, *CLDN5↓, *OCLN↓, *MMP2↑, *MMP↓,
7861- isoO,    Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *GSK‐3β↓, *TNF-α↓, *IL6↓, *IL1β↓, *p‑GSK‐3β↑, *Synergy↑, *COX2/PTGS2↓, *ERK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *OCLN↑, *ZO-1↑, *BBB↝,
8546- Matr,    Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice
- in-vivo, Stroke, NA
*Dose?, *Stroke↓, *BBB↝, *TJ↑, *ZO-1↑, *OCLN↑, *CLDN4↑, *HMGB1↓, *RAGE↓, *JNK↓, *p38↓, *ERK↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *BAX↓, *Bcl-2↑, *Apoptosis↓, *Iron↓, *ACSL4↓, *GPx4↑, *Ferroptosis↓, *neuroP↑, *Inflam↓, *antiOx↑,
5934- TV,    Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties
- Review, Var, NA
*Inflam↓, *antiOx↑, *Bacteria↓, AntiTum↑, *toxicity∅, *IBI↑, *ZO-1↑, *OCLN↑, *COX1↑, *TLR4↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *TAC↑, *NRF2↑, *GutMicro↑,
5935- TV,  CAR,    Effects of thymol and carvacrol supplementation on intestinal integrity and immune responses of broiler chickens challenged with Clostridium perfringens
- in-vivo, Nor, NA
*Dose↝, *OCLN↑, *TLR2↓, *TNF-α↓, Bacteria↓, GutMicro↑,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   lipid-P↑, 1,   ROS↑, 1,   ROS⇅, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   MDM2↑, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   EGFR↓, 1,   ERK↓, 1,   ERK↑, 1,   HER2/EBBR2↓, 1,   MAPK↓, 1,   MAPK↑, 1,   PI3K↓, 2,   STAT3↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   Ki-67↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,   Ki-67↓, 1,   TumCG↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

MMPs↓, 1,   TumMeta↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↑, 1,   IBI↑, 1,   MMP↓, 1,   OCLN↑, 1,   TJ↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 2,   NK cell↑, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 1,   CYP1A1↑, 1,   eff↑, 1,   eff↝, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   HER2/EBBR2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   antiNeop↑, 1,   AntiTum↑, 1,   Risk↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 66

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   Catalase↑, 1,   GPx↑, 1,   GPx4↑, 1,   GSH↑, 2,   HO-1↑, 1,   Iron↓, 1,   lipid-P↓, 1,   NRF2↑, 3,   ROS↓, 3,   SOD↑, 2,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↑, 1,   LDL↓, 2,   lipidLev↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAD↓, 1,   BAX↓, 2,   Bcl-2↑, 1,   Casp3↓, 1,   Casp3↑, 1,   Casp8↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   iNOS↑, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt2↓, 1,   ERK↓, 2,   IKKα↓, 1,   JNK↓, 1,   MAPK↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   MLC2/MYL9↝, 1,   MMP2↑, 1,   MUC1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↝, 2,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN3↑, 1,   CLDN4↑, 1,   CLDN5↓, 1,   IBI↑, 3,   MMP↓, 1,   OCLN↓, 3,   OCLN↑, 6,   OCLN↝, 1,   TJ↑, 3,   ZO-1↓, 2,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↑, 1,   COX2/PTGS2↓, 2,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1β↓, 5,   IL6↓, 5,   Imm⇅, 1,   Inflam↓, 8,   NF-kB↓, 7,   NLRP3↓, 1,   PGE2↓, 1,   RAGE↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 7,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   Dose?, 1,   Dose↝, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   hs-CRP↓, 1,   IL6↓, 5,   RAGE↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiArt↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 4,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 5,   Obesity↓, 1,   Stroke↓, 1,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 2,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 101

Scientific Paper Hit Count for: OCLN, Occludin
2 Carvacrol
2 Thymol-Thymus vulgaris
1 Chlorogenic acid
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Flaxseed/Linseed
1 Fucoidan
1 Gallic acid
1 Hyperoside
1 isoorientin
1 Matrine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1463  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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