HSPD1 / HSP60 Cancer Research Results

HSPD1 / HSP60, HSPD1 = HSP60 / mitochondrial chaperonin 60: Click to Expand ⟱
Source:
Type:

high HSPD1/HSP60 supports tumor survival, mitochondrial proteostasis, metabolism, apoptosis resistance, invasion, and therapy tolerance. But in some settings, reduced HSPD1 can also worsen tumor behavior, so direction must be considered with cancer type/model.

Field Suggested Entry
Target HSP60 / HSPD1
Full Name Heat shock protein family D member 1
Target Class Mitochondrial chaperonin; heat shock protein
Main Complex HSP60-HSP10 mitochondrial chaperonin complex
Primary Biology Mitochondrial protein folding, mitochondrial proteostasis, oxidative stress response, apoptosis regulation, cellular stress survival
Cancer Relevance Medium-high: HSP60 can support tumor mitochondrial stress tolerance, apoptosis resistance, survival signaling, angiogenesis, and therapy resistance in some cancers
AD Relevance Medium: indirect but plausible relevance through mitochondrial dysfunction, proteotoxic stress, oxidative stress, and neurodegenerative protein-quality-control pathways
Therapeutic Direction Context-dependent. In cancer, inhibition may be useful where tumors are HSP60-dependent. In AD/neurodegeneration, preservation or normalization of HSP60-mediated mitochondrial proteostasis is more likely desirable.


Scientific Papers found: Click to Expand⟱
6518- BCP,    beta-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116
angioG↓, VEGF↓, TumVol↓, HSPD1 / HSP60↓, HTRA↓, survivin↓, XIAP↓, P21↑, TumCP↓, TumCMig↓, TumCG↓, Dose↝,
6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, VEGF↓, TumVol↓, Apoptosis↑, HSPD1 / HSP60↓, HTRA↓, survivin↓, XIAP↓, P21↑, *toxicity↓, *neuroP↑, *ROS↓, *COX2↓, *Inflam↓, *cardioP↑, AntiCan↑, ChemoSen↑, ROS↑, MMP↑, Bax:Bcl2↑, TumCG↓,
6160- Cin,    Cinnamaldehyde induces apoptosis and enhances anti-colorectal cancer activity via covalent binding to HSPD1
- vitro+vivo, CRC, HCT116
AntiTum↑, Apoptosis↑, PI3K↓, Akt↓, TumCG↓, TumCCA↑, HSPD1 / HSP60↓, Ki-67↓, ChemoSen↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

HSPD1 / HSP60↓, 3,   HTRA↓, 2,  

Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,   XIAP↓, 2,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 2,   Bax:Bcl2↑, 1,   survivin↓, 2,  

Cell Cycle & Senescence ⓘ

P21↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,   TumCG↓, 3,  

Migration ⓘ

Ki-67↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   VEGF↓, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   Dose↝, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   TumVol↓, 2,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: HSPD1 / HSP60, HSPD1 = HSP60 / mitochondrial chaperonin 60
2 Beta-Caryophyllene
1 Cinnamon
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1472  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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