VEGFR1 Cancer Research Results

VEGFR1, vascular endothelial growth factor receptor 1: Click to Expand ⟱
Source:
Type:

VEGFR1 / FLT1 is a VEGF-family receptor involved in angiogenesis, tumor microenvironment signaling, myeloid/macrophage recruitment, tumor-cell migration/survival, metastasis, and pre-metastatic niche formation. In cancer, membrane VEGFR1 activation is generally pro-cancer, while VEGFR1 inhibition is generally anti-angiogenic and anti-metastatic.
Scientific Papers found: Click to Expand⟱
6271- DL,    D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells
- in-vitro, Colon, SW480 - in-vitro, Colon, HT-29
TumCP↓, Apoptosis↑, Bax:Bcl2↑, VEGF↓, angioG↓, TumMeta↓, VEGFR1↓, MMP9↓,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *eff↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6336- Eug,    Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG
- in-vivo, GC, NA
Apoptosis?, Bcl-2↓, Cyt‑c↝, Casp↑, TumCI↓, angioG↓, MMPs↓, VEGF↓, VEGFR1↓, TIMP2↑, RECK↑,
6491- Nimb,    Nanodelivery and anticancer effect of a limonoid, nimbolide, in breast and pancreatic cancer cells
- Review, PC, NA
eff↑, uPA↓, uPAR↓, p‑EGFR↓, VEGFR1↓, NF-kB↓, IKKα↓, MMP2↓, MMP9↓, TIMP2↑, TumCP↓, IGFR↓, Akt↓, ERK↓, TumCCA↓, BAX↑, BAD↑, FasL⇅, Cyt‑c↑, EPR↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,   Thiols↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PDK1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis?, 1,   Apoptosis↑, 2,   BAD↓, 1,   BAD↑, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 1,   Cyt‑c↑, 1,   Cyt‑c↝, 1,   FasL⇅, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   E2Fs↓, 1,   TumCCA↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCs↓, 1,   EpCAM↓, 1,   ERK↓, 1,   FOXO3↝, 1,   IGFR↓, 1,   mTOR↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 1,   RECK↑, 2,   TIMP1↑, 1,   TIMP2↑, 3,   TumCI↓, 1,   TumCP↓, 2,   TumMeta↓, 2,   uPA↓, 1,   uPAR↓, 1,   VEGFR1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   p‑EGFR↓, 1,   EPR↑, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IKKα↓, 1,   NF-kB↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

p‑EGFR↓, 1,   HER2/EBBR2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   antiNeop↑, 1,  
Total Targets: 63

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSTs↑, 1,   lipid-P↓, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   neuroP↑, 1,   Pain↓, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 21

Scientific Paper Hit Count for: VEGFR1, vascular endothelial growth factor receptor 1
2 Eugenol
1 D-limonene
1 Nimbolide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1476  State#:%  Dir#:%
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