HSP90 Cancer Research Results

HSP90, HSP90: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a critical role in the proper folding, stabilization, and function of many proteins, including those involved in cell signaling, cell cycle regulation, and stress responses.
-Hsp90 interacts with a variety of client proteins that are often mutated or overexpressed in cancer. These include oncogenes (like HER2, BRAF, and AKT) and tumor suppressor proteins (like p53).
-Hsp90 is often overexpressed in cancer cells, which can help them survive under stressful conditions, such as those found in the tumor microenvironment. This overexpression is associated with poor prognosis in several types of cancer.
-HSPs, particularly HSP90, are known to stabilize many proteins that drive cancer progression (oncoproteins).
Scientific Papers found: Click to Expand⟱
554- Anamu,    Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells
- in-vitro, NA, 769-P
TumCCA↑, HSP70/HSPA5↓, HSP90↓,
1352- And,    Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy
- in-vitro, AML, K562
Apoptosis↑, ROS↑, HSP90↓,
175- Api,    Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, DLD1 - vitro+vivo, CRC, LS174T
MMP↓, p‑Akt↓, TumCP↓, TumCI↓, NADH↓, HSP90↓, other↑, talin?,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, NA, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, eff↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, eff↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
1358- Ash,    Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, eff↑, ChemoSen↑, ChemoSen↑, eff↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,
5395- Ash,    Withaferin A Targets Heat Shock Protein 90 in Pancreatic Cancer Cells
- vitro+vivo, PC, PANC1 - in-vitro, PC, MIA PaCa-2
TumCP↓, HSP90↓, Akt↓, CDK4↓, TumCG↓, Apoptosis↑, AntiCan↑,
5398- Ash,    HSP90%2C196381%2C0%2C2.html">Withaferin-A inhibits colorectal cancer growth and metastasis by targeting the HSP90/HIF-1α/EMT axis
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
TumCG↓, TumCMig↓, TumCI↓, HSP90↓, Hif1a↓, EMT↓,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP/DDIT3↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
3162- Ash,    Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A
- Review, Var, NA
lipid-P↓, SOD↑, GPx↑, P53↑, Bcl-2↑, E6↓, E7↓, pRB↑, CycB/CCNB1↑, CDC2↑, P21↑, PCNA↓, ALDH1A1↓, Vim↓, Glycolysis↓, cMyc↓, BAX↑, NF-kB↓, Casp3↑, CHOP/DDIT3↑, DR5↑, ERK↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, HSP90↓,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
3681- BBR,    The efficacy and mechanism of berberine in improving aging-related cognitive dysfunction: A study based on network pharmacology
- in-vivo, AD, NA
*memory↑, *cognitive↑, MAPK↑, *Akt↑, *PI3K↑, *TP53↑, *Jun↓, *HSP90↑, *neuroP↑, *Inflam↓, *antiOx↑, *p16↓, *ER Stress↓,
5674- BTZ,    Bortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic, anti-tumor effects
- in-vivo, GBM, NA - in-vivo, HNSCC, NA
ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, PERK↑, IRE1↑, UPR↑, HSP70/HSPA5↑, HSP90↑, eff↑,
2016- CAP,    Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)
HSP90↓, ATPase↓, eff↑, HSP70/HSPA5↓, other↝, NF-kB↓, EGFR↓, CDK4↓, Src↓, VEGF↓, PI3K↓, Akt↓,
5905- CAR,  HCQ,    Synergistic inhibition of metastatic melanoma by carvacrol and chloroquine: an in vitro and in silico investigation of apoptosis and molecular targets
- in-vitro, Melanoma, NA
eff↑, tumCV↑, IGF-1R↓, SIRT2↓, HSP90↓, TumCP↓, Akt↓,
5939- Cela,  Chemo,    Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
- in-vitro, Melanoma, U266 - in-vitro, Melanoma, RPMI-8226
TumCP↓, ChemoSen↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, XIAP↓, Mcl-1↓, NF-kB↓, IL6↓, STAT3↓, Apoptosis↑, TumCCA↑, Casp3↑, HSP90↓, HO-1↑, JAK2↓, Src↓, Akt↑,
5938- Cela,    Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
- Review, Var, NA
AntiCan↑, BioAv↓, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, angioG↓, Inflam↓, antiOx↑, ChemoSen↑, HSP90↓, ROS↑, RadioS↑, P53↑, NLRP3↓,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
5944- Cela,    HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way
- in-vitro, AML, U937
TumCP↓, TumCCA↑, TumCD↑, HSP90↓, HSP70/HSPA5↑, cycD1/CCND1↓, CDK4↓, CDK6↓, ATPase↓,
5945- Cela,    Targeting the dynamic HSP90 complex in cancer
- Review, Var, NA
HSP90↓,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP/DDIT3↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
5950- Cela,    Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects
- Review, Var, NA
ChemoSen↑, HSP90↓, Akt↓, CDK4↓,
5951- Cela,    Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer
- vitro+vivo, Pca, NA
NF-kB↓, AR↓, MCP1/CCL2↓, Akt↓, HSP90↓, TumCG↓,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
7180- CHA,    Chaetocin: A review of its anticancer potentials and mechanisms
- Review, Var, NA
TumCG↓, TumCP↓, Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumCMig↓, SUV39H↓, TrxR↓, Hif1a↓, HSP90↓, ox-Trx1↑, ROS↑, PI3K↓, Akt↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, DR5↑, CHOP/DDIT3↑, ATF3↑, angioG↓, VEGF↑, LDHA↓, ENO1↓,
6212- CUR,  Rad,    Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers
- Review, Var, NA
RadioS↑, *radioP↑, EGFR↓, TGF-β↓, ROS↑, P53↑, PI3K↓, NF-kB↓, COX2↓, EMT↓, Hif1a↓, HSP90↓, mTOR↓, *Catalase↑, *SOD↑, *MDA↑, *Wound Healing↑, *hepatoP↑, *NF-kB↓, *ROS↓,
6671- Deg,    A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy
- in-vitro, Nor, BEAS-2B - in-vitro, Lung, H1299 - in-vitro, Lung, H460
HSP90↓, toxicity↝, eff↑, chemoPv↑, p53 Wildtype↓, CDK4↓, MAPK↓, Hif1a↓, selectivity↑, compI↓, TumCP↓, BioAv↑,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
4685- EGCG,    Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines
- in-vitro, NPC, TW01 - in-vitro, NPC, TW06
CSCs↓, EMT↓, TumCMig↓, TumCI↓, OCT4↓, Snail↓, Vim↓, E-cadherin↓, HSP70/HSPA5↓, HSP90↓, AntiTum↓,
6391- Eug,  BCP,  5-FU,    Exploring Mechanism of Actions for Eugenol and Beta-Caryophyllene to Combat Colorectal Cancer Chemotherapy Using Network Pharmacology
- in-vitro, CRC, HCT116
eff↑, ChemoSen↑, HSP90↓, Dose↝, TumAuto↑, Apoptosis↑, PI3K↓, Akt↓, mTOR↓, JNK↓, p38↓, EMT↓,
6911- FIS,    New Mitochondria-Targeted Fisetin Derivative Compromises Mitophagy and Limits Survival of Drug-Induced Senescent Breast Cancer Cells
- vitro+vivo, BC, NA
MMP↓, mt-ROS↑, Apoptosis↑, p‑AMPK↑, Akt↓, HSP90↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, TumMeta↓, angioG↓, TumCD↑, selectivity↑, TumVol↓,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp↓, survivin↓,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
7066- GamB,    Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, *cardioP↑, *Inflam↓, *AntiViral↑, *antiOx↑, NF-kB↓, TNF-α↓, COX2↓, iNOS↓, Apoptosis↑, TumAuto↑, TumCP↓, TumCI↓, BioAv↓, ROS↑, MMP↓, SIRT1↓, Akt↓, mTORC1↓, AMPK↑, LRIG1↑, ER Stress↑, Paraptosis↑, Ferroptosis↑, HSP90↓, GSH↓, lipid-P↑, GPx4↓, miR-21↓, PI3K↓, Akt↓, PTEN↑, ASAP2↓, CDK7↓,
7067- GamB,    Gambogic Acid and Its Role in Chronic Diseases
- Review, Var, NA
*NF-kB↓, PI3K↓, Akt↓, STAT3↓, STAT5↓, IL6↓, COX2↓, iNOS↓, MMPs↓, Src↓, PKA↓, CXCR4↑, VEGF↓, Bcl-2↓, Bcl-xL↓, IAP1↓, Mcl-1↓, survivin↓, cycD1/CCND1↓, HSP90↓, HSP70/HSPA5↓, MAPK↓, HATs↓, HDAC↓, FAK↓, ROS↑, MMP7↓, MMP9↓, α-tubulin↑, cl‑PARP↑, TNF-α↓, BID↑, BAD↑, Cyt‑c↑, Casp3↑, Casp9↑, *AntiArt↑, *antiPs↑,
809- GAR,    High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors
- Review, NA, NA
HRI↓, HSP90↓,
7213- GAs,    Anti-Cancer Properties of Ginkgolic Acids in Human Nasopharyngeal Carcinoma CNE-2Z Cells via Inhibition of Heat Shock Protein 90
- vitro+vivo, NPC, CNE2 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Lung, H1975
ATPase↓, HSP90↓, TumCP↓, *toxicity↝, MMP2↓, MMP9↓, HER2/EBBR2↓, c-Raf↓, Akt↓, Bcl-2↓, other↝,
7101- Geld,    Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs
- in-vitro, Nor, NA
*toxicity↑, *AntiBio↑, HSP90↓, AntiCan↑,
7100- Geld,  Rad,    Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin
- in-vitro, Var, NA
HSP90↓, Akt↓, RadioS↑, selectivity↑,
7099- Geld,    Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation
- in-vitro, CRC, DLD1
RadioS↑, EF-1α↓, Akt↓, HSP90↓,
7098- Geld,    Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy
- Review, Var, NA
HSP90↓, *toxicity↑, *toxicity↓, *BioAv↑, eff↑, *toxicity↓, other↝,
7097- Geld,    Geldanamycin, a Naturally Occurring Inhibitor of Hsp90 and a Lead Compound for Medicinal Chemistry
- Review, Var, NA
HSP90↓, *Bacteria↓, *toxicity↑,
7096- Geld,    A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues
- Study, Var, NA
HSP90↓, AntiTum↑,
7095- Geld,    Mechanistic studies on Hsp90 inhibition by ansamycin derivatives
- Study, Var, NA
HSP90↓, selectivity↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
7169- HDN-1,  CHA,    Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90
- in-vitro, Lung, H1975 - in-vitro, Lung, HCC827 - in-vitro, Lung, A549
HSP90↓, TumCP↓, EGFR↓, STAT3↓, Akt↓, ERK↓, Raf↓, cycD1/CCND1↓, SUV39H↓,
2874- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6‐mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
MMP9↓, α-tubulin↑, TumCI↓, HDAC6↓, HSP90↓, TumCMig↓, EGFR↓,
2876- HNK,    Honokiol from Magnolia spp. induces G1 arrest via disruption of EGFR stability through repressing HDAC6 deacetylated Hsp90 function in lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H23 - in-vitro, Lung, HCC827
EGFR↓, HSP90↓,

Showing Research Papers: 1 to 50 of 65
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 65

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ASAP2↓, 1,   CDK7↓, 1,   LRIG1↑, 1,   SUV39H↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   ATF3↑, 2,   Catalase↓, 1,   Catalase↑, 1,   compI↓, 1,   Ferroptosis↑, 4,   GPx↑, 1,   GPx4↓, 3,   GSH↓, 2,   GSR↑, 1,   HO-1↓, 1,   HO-1↑, 5,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 2,   NADH↓, 1,   NQO1↑, 2,   NRF2↓, 3,   NRF2↑, 2,   OXPHOS↓, 1,   Prx↓, 2,   PrxII↓, 1,   ROS↓, 1,   ROS↑, 18,   mt-ROS↑, 1,   SIRT3↓, 1,   SIRT3↑, 1,   SOD↑, 1,   ox-Trx1↑, 1,   TrxR↓, 2,   TrxR1↓, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   CDC2↓, 1,   CDC2↑, 1,   ETC↓, 1,   mitResp↓, 1,   MMP↓, 8,   Mortalin↓, 1,   mtDam↑, 1,   OCR↓, 1,   Raf↓, 1,   c-Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMP↓, 1,   AMPK↑, 4,   p‑AMPK↑, 1,   cMyc↓, 1,   CYP3A4↓, 1,   ENO1↓, 1,   FASN↓, 1,   Glycolysis↓, 2,   lactateProd↓, 1,   LDH↓, 1,   LDHA↓, 2,   NADPH↑, 1,   PI3K/Akt↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   SIRT2↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 23,   Akt↑, 2,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 16,   BAD↓, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 5,   Bax:Bcl2↑, 2,   Bcl-2↓, 8,   Bcl-2↑, 1,   Bcl-xL↓, 2,   BID↓, 1,   BID↑, 1,   BIM↑, 1,   Casp↑, 3,   Casp3↑, 9,   cl‑Casp3↑, 2,   Casp8↑, 2,   Casp9↑, 5,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Chk2↓, 1,   CK2↓, 1,   Cyt‑c↑, 6,   DR5↑, 3,   FADD↑, 1,   Fas↓, 1,   Fas↑, 1,   FasL↑, 2,   Ferroptosis↑, 4,   HEY1↓, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   iNOS↓, 2,   JNK↓, 1,   JNK↑, 3,   MAPK↓, 3,   MAPK↑, 3,   Mcl-1↓, 4,   MDM2↓, 1,   MOMP↑, 1,   Myc↓, 1,   p27↑, 1,   p38↓, 1,   p38↑, 2,   Paraptosis↑, 1,   survivin↓, 6,   Telomerase↓, 2,   TumCD↑, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

EF-1α↓, 1,   FOXD3↑, 1,   HER2/EBBR2↓, 1,   RET↓, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↑, 1,   HATs↓, 1,   miR-21↓, 1,   other↓, 1,   other↑, 1,   other↝, 3,   pRB↑, 1,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 6,   eIF2α↓, 1,   ER Stress↑, 5,   GRP78/BiP↑, 1,   HRI↓, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 2,   HSP90↓, 47,   HSP90↑, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↝, 1,   TumAuto↑, 9,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↓, 1,   DNAdam↑, 1,   m-FAM72A↓, 1,   P53↑, 8,   p53 Wildtype↓, 1,   PARP↑, 1,   cl‑PARP↑, 6,   PCNA↓, 2,   SIRT6↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK2↓, 1,   CDK4↓, 7,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 2,   P21↑, 3,   p‑RB1↓, 1,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD44↓, 1,   cFos↓, 1,   cMET↓, 1,   cMYB↓, 1,   CSCs↓, 6,   EMT↓, 10,   EMT↑, 1,   ERK↓, 3,   FOXO3↑, 3,   p‑GSK‐3β↓, 1,   HDAC↓, 2,   HDAC6↓, 1,   IGF-1R↓, 1,   mTOR↓, 7,   mTORC1↓, 1,   Nanog↓, 2,   NOTCH↓, 1,   NOTCH1↓, 2,   NOTCH3↓, 1,   OCT4↓, 2,   PI3K↓, 11,   PTEN↑, 1,   SOX2↓, 1,   Src↓, 3,   STAT3↓, 10,   p‑STAT3↓, 1,   STAT5↓, 1,   TumCG↓, 6,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

annexin II↓, 1,   AP-1↓, 2,   ATPase↓, 3,   E-cadherin↓, 1,   ER-α36↓, 1,   FAK↓, 2,   MMP2↓, 4,   MMP7↓, 1,   MMP9↓, 7,   MMPs↓, 3,   N-cadherin↓, 2,   PKA↓, 1,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 2,   talin?, 1,   TGF-β↓, 2,   TumCI↓, 10,   TumCMig↓, 4,   TumCP↓, 13,   TumMeta↓, 7,   uPA↓, 2,   Vim↓, 4,   α-tubulin↑, 2,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 14,   ATF4↑, 1,   EGFR↓, 7,   Hif1a↓, 9,   Hif1a↑, 1,   PDGFR-BB↓, 1,   VEGF↓, 7,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 5,   CXCR4↓, 1,   CXCR4↑, 1,   IKKα↓, 1,   IL6↓, 4,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 3,   JAK2↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 16,   TNF-α↓, 4,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 4,   BioAv↝, 2,   ChemoSen↑, 11,   Dose↝, 5,   Dose∅, 1,   eff↓, 1,   eff↑, 24,   Half-Life↝, 1,   RadioS↑, 8,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   E6↓, 4,   E7↓, 4,   EGFR↓, 7,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 4,   LDH↓, 1,   Myc↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↓, 1,   AntiTum↑, 1,   CardioT↑, 1,   chemoP↑, 1,   chemoPv↑, 2,   hepatoP↓, 1,   neuroP↑, 2,   RenoP↑, 1,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 279

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GSH↑, 1,   MDA↑, 1,   NRF2↑, 1,   Prx↑, 1,   ROS↓, 3,   SOD↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   p‑PPARγ↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 2,   Apoptosis↓, 1,   Casp3?, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,   HSP90↑, 2,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p16↓, 1,   TP53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↑, 1,   Jun↓, 1,   mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 1,   PI3K↑, 1,  

Migration(tgid=13) ⓘ

APP↓, 1,   CD31↑, 1,   MMP9↓, 1,   N-cadherin↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 1,   CRP↓, 1,   CXCR4↓, 1,   IL17↓, 1,   IL18↓, 2,   IL1β↓, 2,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 3,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   Dose↑, 1,   Dose⇅, 1,   eff↝, 1,   Half-Life↝, 3,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   IL6↓, 2,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiPs↑, 1,   cardioP↑, 2,   chemoPv↑, 1,   cognitive↑, 2,   hepatoP↑, 2,   memory↑, 2,   neuroP↑, 3,   radioP↑, 1,   toxicity↓, 3,   toxicity↑, 5,   toxicity↝, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,  
Total Targets: 80

Scientific Paper Hit Count for: HSP90, HSP90
9 Celastrol
8 Ashwagandha(Withaferin A)
7 Geldanamycin
4 Gambogic Acid
3 Honokiol
3 Quercetin
2 Apigenin (mainly Parsley)
2 Berberine
2 chaetocin
2 Radiotherapy/Radiation
2 Deguelin
2 Luteolin
2 Magnetic Fields
2 Sulforaphane (mainly Broccoli)
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Bortezomib
1 Capsaicin
1 Carvacrol
1 hydroxychloroquine
1 Chemotherapy
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 Eugenol
1 Beta-Caryophyllene
1 5-fluorouracil
1 Fisetin
1 Garcinol
1 Ginkgolic acids
1 Ginkgetin
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Lactobacillus
1 Methylsulfonylmethane
1 Proanthocyanidins
1 Phenylbutyrate
1 Plumbagin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:149  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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