MUC2 Cancer Research Results

MUC2, Mucin 2, oligomeric mucus/gel-forming: Click to Expand ⟱
Source:
Type:

MUC2 is the dominant intestinal gel-forming mucin and directly affects mucus barrier integrity, inflammation, microbiome interaction, colorectal cancer biology, immune exclusion, and drug penetration. Recent CRC work reports that MUC2 can act as a physical barrier limiting immune infiltration, and reviews describe mucin-rich barriers as contributing to immune evasion and therapy resistance.
Scientific Papers found: Click to Expand⟱
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, eff↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

JNK↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↑, 1,   Wnt↓, 1,  

Migration ⓘ

fascin↓, 1,   MMP9↓, 1,   TGF-β↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

MUC19↓, 1,   MUC2↓, 1,  

Redox & Oxidative Stress ⓘ

lipid-P↓, 1,  

Cell Death ⓘ

MAPK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   GSK‐3β↓, 1,  

Migration ⓘ

VCAM-1↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

ICAM-1↓, 1,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 2,   Inflam↓, 1,   NF-kB↓, 1,   PGE2↓, 1,  

Protein Aggregation ⓘ

AGEs↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,  

Clinical Biomarkers ⓘ

IL6↓, 2,  

Functional Outcomes ⓘ

neuroP↑, 1,  

Infection & Microbiome ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,  
Total Targets: 23

Scientific Paper Hit Count for: MUC2, Mucin 2, oligomeric mucus/gel-forming
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1493  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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