CDKN2C/p18 Cancer Research Results

CDKN2C/p18, CDKN2C / p18INK4c / p18-INK4C: Click to Expand ⟱
Source:
Type:

CDKN2C, p18

Field Description
Target CDKN2C / p18INK4c
Full Name Cyclin-dependent kinase inhibitor 2C
Target Class Endogenous CDK inhibitor; INK4-family tumor suppressor
Main Binding Partners CDK6, CDK4
Primary Biology G1/S cell-cycle checkpoint control, CDK4/6 inhibition, RB/E2F pathway suppression, proliferation restraint
Cancer Relevance Medium-high: tumor suppressor involved in CDK4/6-RB pathway control; loss or downregulation may contribute to pituitary tumors, brain tumors, endocrine tumors, myeloma, and other cancers
AD Relevance Low-medium: indirect relevance through aberrant neuronal cell-cycle re-entry and cell-cycle dysregulation, but not a primary AD therapeutic target
Therapeutic Direction Usually restore/support p18INK4c tumor-suppressor function or compensate for its loss with CDK4/6 pathway inhibition. Direct inhibition of p18 is generally not desirable in cancer.


Scientific Papers found: Click to Expand⟱
6480- LIN,    Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs
- in-vitro, lymphoma, U937 - in-vitro, Var, HeLa
TumCD↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, p16↑, CDKN2C/p18↑,
8610- MO,    Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species
- in-vitro, CRC, HT-29 - in-vitro, Colon, T84
TumCP↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, CDKN2C/p18↑, P21↑, cl‑Casp3↑, cl‑Casp7↑, Apoptosis↑, ROS↑, eff↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   TumCD↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p16↑, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK6↓, 1,   CDKN2C/p18↑, 2,   cycD1/CCND1↓, 1,   P21↑, 2,   p27/CDKN1B↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CDKN2C/p18, CDKN2C / p18INK4c / p18-INK4C
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1499  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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