HTRA Cancer Research Results

HTRA, high-temperature requirement A serine proteases: Click to Expand ⟱
Source:
Type:

HTRA1 is a secreted/extracellular serine protease involved in protein quality control, extracellular matrix remodeling, TGF-β-family signaling, and disease-related proteolysis. The human HtrA family has four members, HtrA1–4, and reviews link HtrA dysregulation to cancer, arthritis, neurodegenerative disease, and reproductive disorders.

-most literature supports HTRA1 and HTRA3 as tumor-suppressive, while HTRA2 is more often associated with tumor growth and metastasis.
Field Suggested Entry
Target HTRA1 / HtrA1
Full Name HtrA serine peptidase 1 / high-temperature requirement A serine peptidase 1
Target Class Secreted/extracellular serine protease; HtrA family protease
Primary Biology Extracellular matrix remodeling, protein quality control, TGF-β-family signaling modulation, proteolysis of misfolded or disease-associated proteins
Cancer Relevance Medium and context-dependent: often described as tumor-suppressive through effects on apoptosis, invasion, extracellular matrix, and chemotherapy response, but cancer type matters
AD Relevance Medium-high: implicated in APP/Aβ processing and broader protein-clearance biology; also relevant to vascular/degenerative disease mechanisms
Therapeutic Direction Context-dependent. In AD/protein-aggregation contexts, supporting appropriate HTRA1 protease activity may be beneficial. In cancer, HTRA1 is often tumor-suppressive, so restoration/support may be more logical than inhibition, but tumor-specific annotation is needed.


Scientific Papers found: Click to Expand⟱
6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, VEGF↓, TumVol↓, Apoptosis↑, HSPD1 / HSP60↓, HTRA↓, survivin↓, XIAP↓, P21↑, *toxicity↓, *neuroP↑, *ROS↓, *COX2↓, *Inflam↓, *cardioP↑, AntiCan↑, ChemoSen↑, ROS↑, MMP↑, Bax:Bcl2↑, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

HSPD1 / HSP60↓, 1,   HTRA↓, 1,  

Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,   XIAP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   survivin↓, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   TumVol↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: HTRA, high-temperature requirement A serine proteases
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1501  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page