PHB Cancer Research Results

PHB, prohibitin: Click to Expand ⟱
Source:
Type:

PHB1 and PHB2 form a conserved mitochondrial inner-membrane complex involved in mitochondrial structure, mitochondrial stress signaling, apoptosis, cell-cycle regulation, metabolism, and aging. Recent structural work describes the human prohibitin complex as linked to mitochondrial stress signaling, housekeeping, cell-cycle progression, apoptosis, and lifespan regulation.
Scientific Papers found: Click to Expand⟱
6587- EU,    Eurycoma longifolia, A Potential Phytomedicine for the Treatment of Cancer: Evidence of p53-mediated Apoptosis in Cancerous Cells
- in-vitro, Lung, A549 - in-vitro, BC, MCF-7
AntiCan↑, Apoptosis↑, P53↑, BAX↑, Bcl-2↓, PHB↓, ANXA1↓, hnRNPA1↓,
6577- EU,    Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28
- in-vitro, Lung, A549
Dose↝, TumCP↓, PHB↓, ANXA1↓, p38↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

PHB↓, 2,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   p38↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Migration ⓘ

hnRNPA1↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

ANXA1↓, 2,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PHB, prohibitin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1505  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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