miR-375 Cancer Research Results

miR-375, miR-375: Click to Expand ⟱
Source:
Type:

miR-375 is a regulatory microRNA that generally functions as a tumour suppressor in head-and-neck and HPV-associated squamous cell carcinomas. It can suppress oncogenic transcripts involved in proliferation, survival, invasion, and extracellular-matrix degradation, including AEG-1/MTDH, IGF1R, JAK2, and YAP1. miR-375 may also directly or indirectly reduce HPV16/18 E6 and E7 expression, thereby supporting p53 and RB tumour- suppressor activity. miR-375 is frequently downregulated in these cancers; therefore, restoration or increased expression is generally considered the favourable direction in this context. Effects may differ by cancer type.



Scientific Papers found: Click to Expand⟱
7394- Amla,    Emblica officinalis extract downregulates pro-angiogenic molecules via upregulation of cellular and exosomal miR-375 in human ovarian cancer cells
- vitro+vivo, Ovarian, NA
antiNeop↑, TumCP↓, TumCMig↓, TumCI↓, TumCG↓, miR-375↑, IGFR↓, Snail↓, E-cadherin↑,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2/PTGS2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, eff↑, eff↑, other↝, RadioS↑, toxicity↓, Dose↝, eff↑, eff↑, eff↑, toxicity↝, eff↓,
6990- Form,    Formononetin induces apoptosis of human osteosarcoma cell line U2OS by regulating the expression of Bcl-2, Bax and MiR-375 in vitro and in vivo
- vitro+vivo, OS, U2OS
TumCP↓, Apoptosis↑, Bcl-2↓, miR-375↓, BAX↑,
6977- Form,    Differential ability of formononetin to stimulate proliferation of endothelial cells and breast cancer cells via a feedback loop involving MicroRNA-375, RASD1, and ERα
- in-vitro, BC, MCF7 - in-vitro, BC, BT474 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs
*Apoptosis↓, miR-375↝, p‑Akt↑, Bcl-2↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-375↓, 1,   miR-375↑, 2,   miR-375↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSTZ1↓, 1,   OXPHOS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   lipoGen↓, 1,   PDK1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↑, 1,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp↑, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   IGFR↓, 1,   mTOR↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 2,   eff↓, 2,   eff↑, 6,   Half-Life↓, 1,   RadioS↑, 1,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,   fatigue↓, 1,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: miR-375, miR-375
2 Formononetin
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Dichloroacetate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1522  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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