PTK2B / PYK2 Cancer Research Results

PTK2B / PYK2, Protein tyrosine kinase 2 beta: Click to Expand ⟱
Source:
Type:

PTK2B / PYK2 (protein tyrosine kinase 2 beta) is a non-receptor tyrosine kinase activated by calcium, integrins, GPCRs, cytokines, and cellular stress. It regulates focal adhesions, cytoskeletal organization, migration, survival, immune signalling, and synaptic function. Increased PYK2 activation commonly supports cancer invasion, metastasis, EMT, and treatment resistance, so inhibition or reduced phosphorylation is usually considered beneficial in cancer studies.



Scientific Papers found: Click to Expand⟱
6793- EPA,    Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells
- in-vitro, Pca, PC3
tumCV↓, ERK↓, PTK2B / PYK2↓, TumCG↓, ROS↑, TumCMig↓, TumCI↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

PTK2B / PYK2↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PTK2B / PYK2, Protein tyrosine kinase 2 beta
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1528  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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