TG/TAG Cancer Research Results

TG/TAG, triglycerides: Click to Expand ⟱
Source:
Type: biomarker, lipid/metabolic

Triglycerides are also called triacylglycerols: molecules consisting of glycerol esterified to three fatty acids. They are the principal storage form of fat and are transported in blood mainly within chylomicrons and very-low-density lipoproteins.

-Triglycerides / intracellular TAG 
Triglycerides are commonly measured in studies involving:
  dyslipidemia and metabolic syndrome;
  insulin resistance;
  obesity and fatty liver disease;
  cardiovascular risk;
  treatment-related metabolic toxicity;
  nutritional and omega-3 interventions.

Different Compartments:
  Serum TG
  Plasma TG
  Intracellular TG (TAG)
  Hepatic TG


Scientific Papers found: Click to Expand⟱
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
9265- BTB,    Cooked Black Turtle Beans Ameliorate Insulin Resistance and Restore Gut Microbiota in C57BL/6J Mice on High-Fat Diets
- in-vivo, Nor, NA
*other↝, *LDL↓, *TG/TAG↓, *IL4↝, *IL5↝, *IFN-γ↝, *TNF-α↝, *IRes↓, *GutMicro↑,
7422- CS,    Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis
- Review, Nor, NA
*LDL↓, *TG/TAG↓, *HDL∅,
7429- CS,    Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
- Review, Nor, NA - Review, IBD, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *ICAM-1↓, *IL1β↓, *IL6↓, *MUC1↑, *OCLN↑, *IBI↑, *ROS↓, *cardioP↑, *SOD↑, *GPx↑, *GSH↑, *TG/TAG↓, *LDL↓, *neuroP↑, *5HT↑, *BDNF↑,
7421- CS,    Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial
- Trial, Nor, NA
*hepatoP↑, *Dose↝, *toxicity↓, *BloodF↑, *ALAT↓, *AST↓, *Bil↓, *LDL↓, *HDL↓, *TG/TAG↓,
9037- CV,  SP,    Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence
- Review, Nor, NA
*NRF2↑, *NF-kB↓, *antiOx↑, *BP↝, *GutMicro↑, *Ingr?, *Synergy↑, *antiOx↑, *ROS↓, *toxicity↝, *MMP↑, *ATP↑, *MitoP↑, *lipid-P↓, *MDA↓, *SOD↑, *GPx↑, *TAC↑, *NK cell↑, *IFN-γ↑, *CRP↓, *SCFAs↑, *TC↓, *LDL↓, *TG/TAG↓, *toxicity↝, AntiTum↑, Ki-67↓, ER-α36↓, P53↑, P21↑, TumCCA↑, Bax:Bcl2↑, Apoptosis↑, Synergy↑,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
8585- FS,    Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
- Review, Nor, NA
*cardioP↑, *Obesity↓, *lipidLev↓, *BP↓, *Inflam↓, *CRP↓, *IL6↓, *ROS↓, *hepatoP↑, *Ingr↝, *GutMicro↑, *Dose↑, *Ingr↝, *Ingr?, *CompStab↝, *MDA↓, *hs-CRP↓, *TNF-α↓, *AntiDiabetic↑, *ALAT↓, *AST↓, *GGT/CD224↓, *TG/TAG↓, *LDL↓, *HDL∅, *TC↓, *glucose↓, *Insulin↓, *SIRT1↑, *Dose↝, *Dose?,
8586- FS,    The Role of Flaxseed in Improving Human Health
- Review, Nor, NA
*lipidLev↓, *BP↓, *HOMA↓, *AntiCan↑, *antiOx↑, *BioAv↑, *Ingr↑, *Ingr↝, *Ingr↝, *GutMicro↑, *CompStab↝, *TC↓, *TG/TAG↓, *LDL↓, *HDL↑, *BP↓, *AntiDiabetic↑, *AntiCan↑, TumCD↑, selectivity↑, TumCP↓, Apoptosis↑, DNAdam↑, i-ROS↑, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, ChemoSen↑, Synergy↑, *Inflam↓, *hs-CRP↓, *VCAM-1↓, *BDNF↑,
8604- FSO,  VitD3,    An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management
- Trial, Diabetic, NA
*TAC↑, *Weight↓, *glucose↓, *Insulin↓, *TG/TAG↓, *TC↓, *QoL↑, *Pain↓, *toxicity↓, *Dose↝,
9232- ITCs,  SFN,    The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update
- Review, AD, NA
*ROS↓, *Inflam↓, *eff↑, *toxicity↓, *HDAC?, *neuroP↑, *NRF2↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑, *CHIP↑, *memory↑, *NeuroI↓, *ROS↓, *BACE/β-secretase↓, *BDNF↑, *GSH↑, *GPx↑, *AChE↓, *BChE↓, *TC↓, *TG/TAG↓, *LDL↓, ROS↑,
8155- lamb,    Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)
- vitro+vivo, Nor, 3T3
*p‑AMPK↑, *PPARγ↓, *CEBPA↓, *adiP↓, *Fas↓, *SREBP1/SREBF1↓, *HMGCR↓, *lipidLev↓, *TG/TAG↓, *Weight↓, *LDL↓, *Obesity↓,
8924- MBS,    Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits
- Review, Var, NA
*hepatoP↑, *AntiCan↑, *Ingr↝, *NO↓, *TNF-α↓, *IL6↓, *IL1β↓, *TG/TAG↓, *BG↓, *LDL↓, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *mt-ROS↓, *Ingr?, Risk↓,
8818- MCP,    Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model
- in-vivo, CRC, NA
AntiTum↑, TG/TAG↓, GutMicro↑,
9086- MGF,    Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial
- Trial, Obesity, NA
*Dose↝, *TG/TAG↓, *FFA/NEFA↓, *IRes↓,
8909- MO,    Effect of Moringa oleifera on inflammatory diseases: an umbrella review of 26 systematic reviews
- Review, Nor, NA
*Ingr↝, *LDL↓, *TG/TAG↓, *TC↓, *HDL↑, *VLDL↓, *ROS↓, *TAC↑, *HK2↑, *Glycolysis↑, *GLUT4↑, Apoptosis↑, P53↑, ROS↑, NF-kB↓, TumCP↓, TumCCA↑, COX2/PTGS2↓, NO↓, MAP2K1/MEK1↓, *GSTs↑, *NQO1↑, *NRF2↑, *ARE↑,
9058- PatchO,    Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation
- in-vivo, LiverDam, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *LDH↓, *ROS↓, *TNF-α↓, *FFA/NEFA↓, *TG/TAG↓, *GSH↑, *GSR↑, *SOD↑, *GSH/GSSG↑, *AMPK↑, *PPARα↑, *CPT1A↑, *NF-kB↓, *SREBP1/SREBF1↓, *Fas↓, *SCD1↓, *lipid-P↓,
7954- RT,    Rutin : therapeutic potential and recent advances in drug delivery
- Review, Nor, NA - Review, IBD, NA
*antiOx↑, *antiAll↑, *Inflam↓, *AntiTum↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *AntiArt↑, *PLA2↓, *chemoP↑, *ROS↓, *Casp3↓, *TNF-α↓, *NF-kB↓, *cardioP↑, *Stroke↓, *TG/TAG↓, *FFA/NEFA↓, *LDL↓, *HDL↑, *AntiDiabetic↑, *MPO↓, *NF-kB↓, *BioAv↓, *BioAv↝,

Showing Research Papers: 1 to 18 of 18

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 18

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 3,   i-ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 4,   Bax:Bcl2↑, 1,   Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Fas↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

MAP2K1/MEK1↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-34a↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   Ki-67↓, 2,   P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   Ki-67↓, 2,   NOTCH1↓, 1,   TumCG↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

EMT↓, 1,   Slug↓, 1,   TRIB3↑, 1,   TumCI↓, 2,   TumMeta↓, 1,   TumMeta↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   NF-kB↓, 1,   NF-kB↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER-α36↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,   P-gp/ABCB1↓, 1,   selectivity↑, 2,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

TG/TAG↓, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 2,   Risk↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 51

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   ARE↑, 1,   Bil↓, 1,   Catalase↑, 2,   GPx↑, 6,   GSH↑, 5,   GSH/GSSG↑, 1,   GSR↑, 1,   GSTs↑, 1,   HDL↓, 1,   HDL↑, 4,   HDL∅, 2,   lipid-P↓, 6,   MDA↓, 3,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 4,   ROS↓, 10,   mt-ROS↓, 1,   SOD↑, 6,   TAC↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↓, 1,   ALAT↓, 4,   AMPK↓, 1,   AMPK↑, 1,   p‑AMPK↑, 1,   ATP↓, 1,   ATP↑, 1,   CPT1A↑, 1,   FFA/NEFA↓, 3,   glucose↓, 2,   Glycolysis↑, 1,   HK2↑, 1,   HMG-CoA↓, 1,   LDL↓, 13,   lipidLev↓, 3,   NAD↓, 1,   PLA2↓, 1,   SCD1↓, 1,   SCFAs↑, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↓, 1,   Casp3↓, 2,   Casp9↓, 1,   Cyt‑c↓, 1,   Fas↓, 2,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   HDAC?, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   CHIP↑, 1,   HMGCR↓, 1,  

Migration(tgid=13) ⓘ

MUC1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,   VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   GLUT4↑, 1,   IBI↑, 1,   MMP↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IFN-γ↝, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 2,   IL4↝, 1,   IL5↝, 1,   IL6↓, 4,   Imm↓, 1,   Inflam↓, 7,   NeuroI↓, 1,   NF-kB↓, 5,   NK cell↑, 1,   PGE2↓, 1,   TNF-α↓, 6,   TNF-α↝, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BChE↓, 1,   BDNF↓, 1,   BDNF↑, 3,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↑, 1,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 1,   CompStab↝, 2,   Dose?, 1,   Dose↑, 1,   Dose↝, 5,   eff↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP↓, 1,   AST↓, 4,   BG↓, 1,   Bil↓, 1,   BloodF↑, 1,   BP↓, 3,   BP↝, 1,   CRP↓, 3,   HOMA↓, 1,   hs-CRP↓, 2,   IL6↓, 4,   IRes↓, 2,   LDH↓, 1,   TC↓, 6,   TG/TAG↓, 16,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   AntiArt↑, 1,   AntiCan↑, 3,   AntiDiabetic↑, 5,   AntiTum↑, 1,   cardioP↑, 4,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 6,   memory↑, 1,   neuroP↑, 5,   Obesity↓, 2,   Pain↓, 1,   QoL↑, 1,   Stroke↓, 1,   toxicity↓, 3,   toxicity↝, 3,   Weight↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,   GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 3,   Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 153

Scientific Paper Hit Count for: TG/TAG, triglycerides
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Flaxseed/Linseed
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Black turtle bean
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Emodin
1 Flaxseed Oil
1 Vitamin D3
1 Isothiocyanates
1 Sulforaphane (mainly Broccoli)
1 lambertianic acid
1 Mung Bean Sprouts
1 Modified Citrus Pectin
1 Mangiferin
1 Moringa oleifera
1 Patchouli Oil (Pogostemon cablin)
1 Rutin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1529  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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