Urea Cancer Research Results

Urea, Urea: Click to Expand ⟱
Source:
Type: Biomarker

Urea is the principal nitrogenous waste product formed in the liver through the urea cycle from ammonia generated during amino-acid metabolism. It is transported in blood and excreted mainly by the kidneys. Urea is a metabolite and clinical biomarker, not a molecular signalling target. Its direction is context-dependent: increased serum urea may indicate renal impairment, dehydration, protein catabolism, or treatment toxicity, while reduced urea may reflect impaired hepatic synthesis, malnutrition, or altered nitrogen metabolism. Reference.



Scientific Papers found: Click to Expand⟱
6885- FA,    Mitigation of renal toxicity induced by paraquat using ferulic acid: Role of inflammatory pathways
- in-vivo, Nor, NA
*Dose↝, *TAC↑, *MDA↓, *RenoP↑, *PI3K↓, *Akt↓, *ROS↓, *Inflam↓, PPARγ↝, *NF-kB↓, *IL6↓, *TNF-α↓, *iNOS↓, *ALAT↓, *AST↓, *Urea↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑,
7049- GA,    Pharmacological effects of gallic acid in health and diseases: A mechanistic review
- Review, Var, NA
*antiOx↑, *Inflam↓, *antiNeop↑, *cardioP↑, *Bacteria↓, *AST↓, *ALAT↓, *ALP↓, *lipid-P↓, *GSH↑, *Catalase↑, *GPx↑, *GSTs↑, *Urea↓, *creat↓, tumCV↓, TumCCA↑, i-Ca+2↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, MMP↓, ROS↑, MMPs↓, *GastroP↑, *hepatoP↑, *ROS↓, *AChE↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
8225- LCA,  Cisplatin,    Licochalcone A protects against cisplatin-induced acute kidney injury via the modulation of Nrf2/Keap1-mediated ferroptosis and apoptosis
- in-vivo, Nor, NA
*RenoP↑, *Urea↓, *BUN↓, *creat↓, *Apoptosis↓, *Ferroptosis↓, *Iron↓, *ROS↓, *lipid-P↓, *mtDam↓, *NRF2↑,
8904- MOR,    A 13-week subchronic toxicity study of dietary administered morin in F344 rats
- in-vivo, Nor, NA
*Dose?, *ALAT↓, *ALP↓, *creat↑, *Urea↑, *toxicity↝,
8883- MOR,  5-FU,    Morin Mitigates 5-Fluorouracil-Induced Nephrotoxicity by Activating Nrf2/HO-1 and FXR, and Suppressing ERK/VCAM-1 and NF-κB Pathways
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *Dose↝, *Urea↓, *creat↓, *ROS↓, *NRF2↑, *HO-1↑, *NR1H4↑, *RenoP↑, *TNF-α↓, *IL6↓, *ERK↓, *VCAM-1↓, *NF-kB↓, *chemoP↑,
8453- OM,    Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress
- in-vivo, Nor, NA
Dose↝, creat↓, Urea↓, uricA↓, BUN↓, MDA↓, GSH↑, SOD↑, Catalase↑, RenoP↑, *ROS↓,
8434- OM,    Traditional use, phytochemistry, toxicology, and pharmacology of Origanum majorana L
- Review, Var, NA
*Bacteria↓, *AntiFungal↑, *antiOx↑, *AntiP↑, *AntiDiabetic↑, *AntiCan↑, *RenoP↑, *Inflam↓, *Analgesic↑, *antiPy↑, *antiM↑, *Ingr↝, *Ingr↝, *creat↓, *Urea↓, *uricA↓, *BUN↓, *ALAT↓, *AST↓, *ALP↓, *Catalase↑, *SOD↑, *GSTA1↑,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 2,   GSH↑, 1,   MDA↓, 2,   ROS↓, 1,   ROS↑, 2,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SCD1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   Bcl-2↓, 1,   Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 2,   CellShr↑, 1,   Cyt‑c↑, 1,   FADD↑, 1,   IAP2/BIRC3↓, 1,   MOMP↑, 1,   TNFR 1↑, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   mTOR↓, 1,   PI3K↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   miR-124-3p↓, 1,   tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK4↓, 1,   CDK6↑, 1,   ChrCon↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

i-Ca+2↑, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibronectin↓, 1,   MALAT1↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   Twist↓, 1,   Vim↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   VCAM-1↓, 1,   VEGF↓, 1,   VEGFR1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 1,   ICAM-1↓, 1,   Imm↑, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NK cell↑, 1,   Th1 response↑, 1,   Th17↑, 1,   TRADD↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 1,   Dose↝, 4,   eff↑, 1,   selectivity↑, 1,   Synergy?, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BUN↓, 1,   creat↓, 1,   EZH2↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 3,   NP/CIPN↓, 1,   PFS↑, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 2,   TumVol↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 92

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↑, 5,   GPx↑, 3,   GSH↑, 2,   GSTs↑, 1,   HO-1↑, 2,   Iron↓, 1,   lipid-P↓, 3,   MDA↓, 2,   MPO↓, 1,   NRF2↑, 3,   ROS↓, 7,   SOD↑, 4,   TAC↑, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 5,   ATP↑, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Casp12↓, 1,   Casp3↓, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   CREB↑, 1,   ERK↓, 1,   p‑JNK↓, 1,   mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   other↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

Migration(tgid=13) ⓘ

TGF-β↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   IBI↑, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   IFN-γ↓, 1,   IL10↑, 1,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 3,   Imm↑, 1,   Inflam↓, 5,   LPS↓, 1,   NeuroI↓, 1,   NF-kB↓, 2,   NLRP3↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 1,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

NR1H4↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↝, 1,   Dose?, 1,   Dose↝, 4,   eff↑, 1,   GSTA1↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 3,   AST↓, 4,   BUN↓, 2,   creat↓, 6,   creat↑, 1,   IL6↓, 3,   Urea↓, 7,   Urea↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   antiM↑, 1,   antiNeop↑, 1,   antiPs↑, 1,   antiPy↑, 1,   cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 2,   hepatoP↑, 4,   memory↑, 1,   neuroP↑, 3,   Obesity↓, 1,   RenoP↑, 5,   Stroke↓, 1,   toxicity↓, 1,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiP↑, 1,   Bacteria↓, 2,   GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 110

Scientific Paper Hit Count for: Urea, Urea
2 Morin
2 Marjoram (Origanum majorana)
1 Ferulic acid
1 Gallic acid
1 Hydrogen Gas
1 Licochalcone A
1 Cisplatin
1 5-fluorouracil
1 Spirulina(Arthrospira/Limnospira)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1535  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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