FPN Cancer Research Results

FPN, Ferroportin: Click to Expand ⟱
Source:
Type: Biomarker

Ferroportin (FPN; gene symbol SLC40A1) is the principal cellular iron-export protein. It transports iron out of cells and is negatively regulated by hepcidin, which promotes ferroportin internalization and degradation. In many cancers, reduced ferroportin expression decreases iron export, increases intracellular iron retention, and may support proliferation and tumour progression. Therefore, FPN ↓ is commonly tumour-promoting, while FPN ↑ generally lowers intracellular iron; however, increased iron export may also reduce ferroptosis sensitivity. Record expression, protein abundance, or iron-export activity according to the specific study. Gene reference; Cancer and iron review.



Scientific Papers found: Click to Expand⟱
6891- Fer,    Iron oxide nanoparticles inhibit tumor growth by ferroptosis in diffuse large B-cell lymphoma
- vitro+vivo, lymphoma, NA
TumCG↓, Ferroptosis↑, i-Iron↑, lipid-P↑, GPx4↓, ROS↑, Fenton↑, TfR1/CD71↝, FPN↝, LIP↑, TumCP↓, Apoptosis↑, TumCG↓,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

FPN↝, 1,   LIP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↑, 1,   Ferroptosis↑, 2,   GPx4↓, 1,   Iron↝, 1,   i-Iron↑, 1,   lipid-P↑, 1,   ROS↓, 1,   ROS↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   TfR1/CD71↝, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Ferroptosis↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 2,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,   Inflam↓, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

anemia↓, 1,   Aβ42↓, 1,   FPN↑, 1,   RBC↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↓, 1,   GPx↑, 1,   GSH↑, 1,   ROS↓, 1,   SOD↑, 1,   TAC↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   TfR1/CD71↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Apoptosis↓, 1,   Casp3↓, 1,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PTEN↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ferritin↓, 1,   GutMicro↑, 1,   HemoG↑, 1,   IL6↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 31

Scientific Paper Hit Count for: FPN, Ferroportin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1536  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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