miR-149 Cancer Research Results

miR-149, miR-149: Click to Expand ⟱
Source:
Type:

MicroRNA-149 (miR-149; mature strands miR-149-5p and miR-149-3p) is a small non-coding RNA that regulates gene expression by binding target mRNAs and promoting transcript degradation or translational repression. In many cancers, particularly digestive, reproductive, renal, lung, breast, and bone malignancies, miR-149 ↓ is the more commonly reported pattern and miR-149 functions as a tumour suppressor. Restoration or miR-149 ↑ can inhibit cancer-cell proliferation, migration, invasion, epithelial-mesenchymal transition, and treatment resistance, while promoting apoptosis in susceptible models. Reported downstream targets and pathways include AKT, FOXM1, TGF-β/SMAD, WNT/β-catenin, NOTCH, and the TWEAK/Fn14 axis. However, miR-149 can act as an oncogenic microRNA in selected cancers, so its direction must be recorded according to tumour type, mature strand, specimen, and experimental context. Do not combine miR-149-5p and miR-149-3p results when the strand is identified. Cancer review; Tumour-suppressive example.



Scientific Papers found: Click to Expand⟱
6965- Form,    Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways
- in-vitro, CRC, HCT116
TumCP↓, TumCI↓, cycD1/CCND1↓, TumCCA↑, MMP2↓, MMP9↓, miR-149↑, tumCV↓, p‑PI3K↓, p‑Akt↓, p‑STAT3↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-149↑, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑PI3K↓, 1,   p‑STAT3↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,   TumCI↓, 1,   TumCP↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-149, miR-149
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1542  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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