MLC2/MYL9 Cancer Research Results

MLC2/MYL9, Regulatory myosin light chain: Click to Expand ⟱

Source:

Type:

Regulatory myosin light chain (MLC2; commonly MYL9 in smooth-muscle and nonmuscle-cell studies) regulates actomyosin contraction through phosphorylation-dependent activation of myosin II. In cancer, MLC2 phosphorylation ↑ generally increases actomyosin contractility, stress-fibre formation, cell motility, invasion, and metastatic potential. Conversely, phosphorylated MLC2 ↓ commonly indicates inhibition of the RhoA/ROCK or MLCK contractility pathways and is usually anti-migratory. Total MLC2/MYL9 expression may also be increased in some cancers, but phosphorylation is the more direct functional endpoint. MYL9 gene reference; Cancer review.

Scientific Papers found: Click to Expand⟱

6978-

Form,

Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway

vitro+vivo,

Nor,

HUVECs

zebrafish

*angioG↑, *VEGF↑, *MYPT1 / PPP1R12A↑, *MMP2↑, *MMP9↑, *p‑MYPT1 / PPP1R12A↑, *p‑MLC2/MYL9↑, *p‑LIMK1↑, *p‑Cofilin↑, *ROCK1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

p‑LIMK1↑, 1, p‑MLC2/MYL9↑, 1, MYPT1 / PPP1R12A↑, 1, p‑MYPT1 / PPP1R12A↑, 1,

Migration(tgid=13) ⓘ

p‑Cofilin↑, 1, MMP2↑, 1, MMP9↑, 1, ROCK1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1, VEGF↑, 1,
Total Targets: 10

Scientific Paper Hit Count for: MLC2/MYL9, Regulatory myosin light chain

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells