LIMK1 Cancer Research Results

LIMK1, LIM domain kinase 1: Click to Expand ⟱

Source:

Type:

LIM domain kinase 1 (LIMK1) is a serine/threonine kinase that regulates actin-cytoskeleton dynamics primarily by phosphorylating and inactivating cofilin. LIMK1 acts downstream of Rho-family GTPases and kinases including ROCK and PAK. In many cancers, LIMK1 expression or activity ↑ promotes actin polymerization, cell migration, invasion, epithelial-mesenchymal transition, and metastatic progression. Conversely, LIMK1 inhibition or activity ↓ commonly reduces cancer-cell motility and invasion. Gene reference.

Scientific Papers found: Click to Expand⟱

6978-

Form,

Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway

vitro+vivo,

Nor,

HUVECs

zebrafish

*angioG↑, *VEGF↑, *MYPT1 / PPP1R12A↑, *MMP2↑, *MMP9↑, *p‑MYPT1 / PPP1R12A↑, *p‑MLC2/MYL9↑, *p‑LIMK1↑, *p‑Cofilin↑, *ROCK1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

p‑LIMK1↑, 1, p‑MLC2/MYL9↑, 1, MYPT1 / PPP1R12A↑, 1, p‑MYPT1 / PPP1R12A↑, 1,

Migration(tgid=13) ⓘ

p‑Cofilin↑, 1, MMP2↑, 1, MMP9↑, 1, ROCK1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1, VEGF↑, 1,
Total Targets: 10

Scientific Paper Hit Count for: LIMK1, LIM domain kinase 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells