ASAP2 Cancer Research Results

ASAP2, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; AMAP2: Click to Expand ⟱
Source:
Type:

ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; AMAP2) is a multidomain ADP-ribosylation-factor GTPase-activating protein involved in membrane trafficking, actin-cytoskeleton organization, focal-adhesion dynamics and cell migration. In pancreatic ductal adenocarcinoma, ASAP2 can be amplified and overexpressed, and high expression has been associated with poorer prognosis. Experimental ASAP2 disruption reduced pancreatic-cancer-cell migration, supporting a role in tumour invasion and metastasis. In hepatocellular carcinoma, elevated ASAP2 promoted proliferation, migration, invasion, epithelial–mesenchymal transition and lung metastasis, partly by sustaining HGF/c-MET signalling. The typical cancer-associated direction is up, while the desired anticancer modulation is down or functional inhibition.



Scientific Papers found: Click to Expand⟱
7066- GamB,    Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, *cardioP↑, *Inflam↓, *AntiViral↑, *antiOx↑, NF-kB↓, TNF-α↓, COX2↓, iNOS↓, Apoptosis↑, TumAuto↑, TumCP↓, TumCI↓, BioAv↓, ROS↑, MMP↓, SIRT1↓, Akt↓, mTORC1↓, AMPK↑, LRIG1↑, ER Stress↑, Paraptosis↑, Ferroptosis↑, HSP90↓, GSH↓, lipid-P↑, GPx4↓, miR-21↓, PI3K↓, Akt↓, PTEN↑, ASAP2↓, CDK7↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ASAP2↓, 1,   CDK7↓, 1,   LRIG1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   lipid-P↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↑, 1,   Ferroptosis↑, 1,   iNOS↓, 1,   Paraptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTORC1↓, 1,   PI3K↓, 1,   PTEN↑, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 1,  
Total Targets: 32

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: ASAP2, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; AMAP2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1575  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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