IL6 Cancer Research Results

IL6, Interleukin-6: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Interleukin-6 (IL-6) is a cytokine that plays a significant role in inflammation and the immune response. It is produced by various cell types, including T cells, B cells, macrophages, and fibroblasts.
IL-6 can promote tumor cell proliferation and survival. Many cancer cells produce IL-6, which can create an autocrine loop that supports their growth.
IL-6 is a high-value inflammatory biomarker in cancer, reporting cytokine burden, catabolic stress, and STAT3-linked survival signaling. While not tumor-specific, elevated and rising IL-6 strongly predicts poor prognosis and limited treatment tolerance, making it an important system-state indicator alongside CRP and ferritin.


Scientific Papers found: Click to Expand⟱
2326- 2DG,    Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2–Signal Transducer and Activator of Transcription 3 Pathway
- in-vivo, Nor, NA
PKM2↓, Inflam↓, TNF-α↓, IL6↓, OS↑,
5463- AF,    Will Auranofin Become a Golden New Treatment Against COVID-19?
- Review, Covid, NA
IL6↓, NF-kB↓, ATF2↓, TrxR↓, ROS↑, Apoptosis↑, IL6↓, Dose↑,
5470- AF,    Exploring a Therapeutic Gold Mine: The Antifungal Potential of the Gold-Based Antirheumatic Drug Auranofin
- Review, Var, NA
TrxR↓, other↝, IL6↑, IL8↑, NK cell⇅, COX2↓, NOS2↓, NRF2↑, Prx↑, Half-Life↑, Dose↝, ROS↑, NF-kB↓,
5444- AG,    A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine
- Review, Var, NA
*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,
5436- AG,    Therapeutic Effect of Astragalus Polysaccharides on Hepatocellular Carcinoma H22-Bearing Mice
- in-vivo, HCC, NA
TumCG↓, BAX↑, Bcl-2↓, IL2↑, IL6↑, TNF-α↑, toxicity↓,
4387- AgNPs,    Attenuation of diethylnitrosamine (DEN) - Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles
- in-vitro, Liver, NA
IL6↓, TNF-α↓, IL1β↓, hepatoP↑,
4360- AgNPs,    Silver Nanoparticles as Real Topical Bullets for Wound Healing
- Study, Nor, NA
*other↝, *toxicity↓, *eff↑, *eff↑, *Inflam↓, *IL6↓, *TGF-β↑, *MMP9↓, *eff↑,
4363- AgNPs,    Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma
- in-vivo, fibroS, NA
TumVol↓, TNF-α↓, IL6↓, IL1β↓, *toxicity↝, TumCG↓, selectivity↑, selectivity↑, Weight↑, ROS↑, NO↑,
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
2661- AL,    Allicin alleviates traumatic brain injury-induced neuroinflammation by enhancing PKC-δ-mediated mitophagy
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *ROS↓, *NLRP3↓, *TLR4↓, *PKCδ↑, neuroP↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
232- AL,    A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans
- Human, Nor, NA
*AhR↑, *ARNT↑, *Hif1a↑, *Jun↑, *NFAT↑, *NFAM1↑, *REL↑, *OSM↑, *NFAT↑, *CXCc↑, *IL2↑, *IL6↑, *LIF↑,
3456- ALA,    Renal-Protective Roles of Lipoic Acid in Kidney Disease
- Review, NA, NA
*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,
3449- ALA,    Alpha-Lipoic Acid Downregulates IL-1β and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells
- in-vitro, AD, SK-N-BE
*antiOx↑, *NRF2↑, *NF-kB↓, *IL1β↓, *IL6↓, neuroP↑,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, NA, NA
NRF2↑, COX2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
1543- Api,    Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms
- Review, NA, NA
TNF-α↓, IL1β↓, IL6↓, IL10↓, COX2↓, iNOS↓, Inflam↓, Dose∅, Dose∅,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
3665- ART/DHA,    Artemisinin B Improves Learning and Memory Impairment in AD Dementia Mice by Suppressing Neuroinflammation
- Review, AD, NA
*Inflam↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *MyD88↓, *NF-kB↓, *TLR4↓, *memory↑,
3667- ART/DHA,    Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
- Review, Sepsis, NA
*cognitive↑, *neuroP↑, *TNF-α↓, *IL6↓, *NF-kB↓, *AMPK↑, *ROS↓, *Akt↑, *MCP1↓, *MIP2↓, *TGF-β↑, *Inflam↓,
4278- ART/DHA,    Artemisinin Ameliorates the Neurotoxic Effect of 3-Nitropropionic Acid: A Possible Involvement of the ERK/BDNF/Nrf2/HO-1 Signaling Pathway
- in-vivo, NA, NA
*IL6↓, *Casp3↓, *Casp9↓, *BDNF↑, *ERK↑, *NRF2↑, *HO-1↑, *neuroP↑, *antiOx↑, *Inflam↓,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, KDR/FLK-1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
565- ART/DHA,    Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma
STAT↓, IL6↓, pro‑Casp3↝, Bcl-xL↝, survivin↝,
1074- ART/DHA,    Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells
- in-vitro, Nor, BV2
*TNF-α↓, *IL6↓, *MCP1↓, *NO↓, *iNOS↓, *IκB↑,
5396- Ash,    Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
- Review, Var, NA
selectivity↑, ROS↑, Apoptosis↑, ChemoSen↑, RadioS↑, NF-kB↓, ER-α36↓, P53↑, *ROS∅, γH2AX↑, DNAdam↑, MMP↓, XIAP↓, IAP1↓, survivin↓, SOD↓, Dose↝, IL6↓, TNF-α↓, COX2↓, p‑Akt↓, NOTCH1↓, FOXO↑, Casp↑, MMP2↓, CSCs↓, *ROS↓, *SOD2↑, chemoP↑, ChemoSen↑, RadioS↑,
3685- Ash,    Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation
- in-vivo, NA, NA
*TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *NOX↓, *cognitive↑, *Inflam↓, *NF-kB↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
1177- Ash,    Withaferin A downregulates COX-2/NF-κB signaling and modulates MMP-2/9 in experimental endometriosis
- in-vivo, EC, NA
TumVol↓, MMP2↓, MMP9↓, NF-kB↓, COX2↓, NO↓, IL1β↓, IL6↓,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
5384- AsP,  MEL,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
1146- AsP,    Potential use of nanoformulated ascorbyl palmitate as a promising anticancer agent: First comparative assessment between nano and free forms
- in-vivo, Nor, NA
TumCCA↑, Apoptosis↑, IL6↓, STAT3↓, angioG↓, TumMeta↓, VEGF↓, MMP9↓, SOD↑, Catalase↑, GSH↓, MDA↓, NO↓, *BioAv↑,
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
5418- ASTX,    Astaxanthin supplementation mildly reduced oxidative stress and inflammation biomarkers: a systematic review and meta-analysis of randomized controlled trials
- Review, Nor, NA
*MDA↓, *SOD↑, *IL6↓, *ROS↓, *Inflam↓,
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
5371- AV,    Assessment of the immunomodulatory effect of Aloe vera polysaccharides extracts on macrophages functions
- Study, Nor, NA
*eff↑, *IL6↑, *toxicity↓, *Imm↑,
5568- B-Gluc,  immuno,    Beta-glucans in oncology: revolutionizing treatment with immune power & tumor targeting
- Review, Var, NA
TNF-α↓, IL6↓, NF-kB↓, PD-L1↓, Imm↑, BAX↑, Bcl-2↓, TumCCA↑, angioG↓, VEGF↓, MMPs↓, OS↑, chemoP↑, eff↑, BioAv↑,
5577- B-Gluc,    Lentinan progress in inflammatory diseases and tumor diseases
- Review, Var, NA - Review, IBD, NA
AntiTum↑, GutMicro↑, *Inflam↓, *TNF-α↓, *NF-kB↓, ChemoSen↑, OS↑, Imm↑, IL6↓, ERK↓, MAPK↓, *antiOx↑, eff↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
4276- BA,    Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
- in-vivo, Stroke, NA
*BDNF↑, *neuroP↑, *TrkB↑, *PI3K↑, *Akt↑, *MAPK↑, *ERK↑, *NO↓, *MDA↓, *SOD↑, *TNF-α↓, *IL1β↓, *IL6?,
1522- Ba,    Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production
- in-vitro, Nor, RAW264.7
*p‑STAT1↓, *p‑STAT3↓, *p‑JAK1↓, *p‑JAK2↓, *iNOS↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓,
2610- Ba,    Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice
- in-vivo, Nor, NA
*TNF-α↑, *IL6↑, *hepatoP↑,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2627- Ba,  Cisplatin,    Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways
RenoP↑, *iNOS↑, *TNF-α↓, *IL6↓, *NF-kB↓, *MAPK↓, *ERK↓, *JNK↓, *antiOx↑, *NRF2↓, *HO-1↑, *Cyt‑c∅, *Casp3∅, *Casp9∅, *PARP∅,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,

Showing Research Papers: 1 to 50 of 277
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 277

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   Ferroptosis↑, 1,   GSH↓, 2,   HO-1↑, 1,   lipid-P↑, 1,   MDA↓, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 3,   p‑NRF2↓, 1,   OXPHOS↓, 1,   Prx↑, 1,   ROS↓, 1,   ROS↑, 9,   ROS⇅, 1,   i-ROS↑, 1,   SOD↓, 2,   SOD↑, 1,   TrxR↓, 3,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 4,   MPT↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   AMPK↑, 3,   p‑AMPK↑, 1,   cMyc↓, 3,   FASN↓, 2,   FDG↓, 1,   Glycolysis↓, 1,   Histones↝, 1,   HK2↓, 1,   HMG-CoA↓, 1,   LDH↓, 1,   LDHA↓, 1,   NADPH↑, 1,   PDH↑, 1,   PDK1↓, 1,   PKM2↓, 2,   PPARγ↓, 1,   PPARγ↑, 1,   p‑S6↓, 1,  

Cell Death ⓘ

Akt↓, 8,   p‑Akt↓, 4,   Apoptosis↑, 9,   ASK1↑, 1,   ATF2↓, 1,   BAX↑, 4,   BAX⇅, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 8,   Bcl-xL↓, 2,   Bcl-xL↝, 1,   Casp↑, 2,   Casp12↑, 2,   Casp3↑, 6,   pro‑Casp3↝, 1,   Casp8↑, 1,   Casp9↑, 4,   p‑Chk2↑, 1,   CK2↓, 1,   Cyt‑c↑, 4,   Fas↓, 1,   Fas↑, 1,   FasL↓, 1,   Ferroptosis↑, 1,   IAP1↓, 1,   iNOS↓, 3,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 1,   oncosis↑, 1,   p27↑, 2,   p38↓, 1,   p38↑, 2,   survivin↓, 2,   survivin↝, 1,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

p‑ATM↑, 1,   p‑ATR↑, 1,   CHK1↓, 1,   p‑CHK1↑, 1,   DNAdam↑, 4,   HR↓, 1,   p16↑, 1,   P53↑, 5,   cl‑PARP↑, 1,   PCNA↓, 1,   RAD51↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 3,   CycD3↓, 1,   cycE1↓, 1,   P21↑, 2,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

cMET↓, 1,   CSCs↓, 3,   EMT↓, 3,   ERK↓, 3,   p‑ERK↓, 2,   FOXO↑, 1,   FOXO3↑, 2,   Gli↓, 1,   Gli1↓, 1,   GSK‐3β↓, 2,   HDAC↓, 2,   HDAC1↓, 1,   HDAC10↓, 1,   HDAC3↓, 1,   IGF-1↓, 1,   mTOR↓, 4,   p‑mTOR↓, 2,   NOTCH↓, 1,   NOTCH1↓, 2,   NOTCH3↓, 1,   OCT4↓, 1,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 6,   PTEN↑, 1,   Shh↓, 2,   Smo↓, 1,   SOX2↓, 1,   STAT↓, 1,   STAT3↓, 9,   TOP2↓, 1,   TumCG↓, 5,   Wnt↓, 1,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

Ca+2↑, 2,   CDK4/6↓, 1,   E-cadherin↑, 3,   ER-α36↓, 1,   FAK↓, 1,   p‑FAK↓, 1,   ITGB1↑, 1,   Ki-67↓, 1,   MMP2↓, 10,   MMP9↓, 10,   MMPs↓, 2,   N-cadherin↓, 2,   NCAM↑, 1,   ROCK1↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP2↓, 1,   TIMP2↑, 1,   TumCI↓, 3,   TumCMig↓, 5,   TumCP↓, 5,   TumMeta↓, 2,   Twist↓, 2,   uPA↓, 2,   Vim↓, 2,   ZO-1↑, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   EGFR↓, 2,   EGR4↓, 1,   Hif1a↓, 8,   KDR/FLK-1↓, 1,   NO↓, 4,   NO↑, 1,   VEGF↓, 10,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 7,   CRP↓, 1,   IFN-γ↓, 1,   IKKα↓, 1,   p‑IKKα↓, 1,   IL1↓, 2,   IL10↓, 1,   IL1α↓, 1,   IL1β↓, 7,   IL2↓, 1,   IL2↑, 1,   IL6↓, 23,   IL6↑, 2,   IL8↓, 4,   IL8↑, 1,   Imm↑, 2,   Inflam↓, 4,   MIP2↓, 1,   NF-kB↓, 11,   NK cell↑, 1,   NK cell⇅, 1,   PD-L1↓, 2,   PGE2↓, 1,   TNF-α↓, 12,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 7,   Dose↑, 1,   Dose↝, 3,   Dose∅, 2,   eff↓, 1,   eff↑, 7,   eff↝, 1,   Half-Life↓, 1,   Half-Life↑, 1,   RadioS↑, 3,   selectivity↑, 5,  

Clinical Biomarkers ⓘ

CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 2,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   IL6↓, 23,   IL6↑, 2,   Ki-67↓, 1,   LDH↓, 1,   NOS2↓, 1,   PD-L1↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 4,   chemoPv↑, 1,   cognitive?, 1,   cognitive↑, 1,   hepatoP↑, 1,   neuroP↑, 3,   OS↑, 4,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   TumVol↓, 2,   Weight↑, 1,  
Total Targets: 249

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 15,   Catalase↑, 3,   GPx↑, 4,   GSH↑, 6,   GSR↑, 1,   GSTs↑, 2,   HO-1↑, 3,   Keap1↓, 1,   lipid-P↓, 4,   MDA↓, 8,   MPO↓, 2,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 6,   ROS?, 1,   ROS↓, 17,   ROS∅, 1,   SOD↑, 9,   SOD2↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   adiP↑, 1,   ALAT↓, 1,   AMPK↑, 2,   BUN↓, 1,   cAMP↑, 2,   GlucoseCon↑, 1,   H2S↑, 1,   LDH↓, 2,   p‑PPARγ↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

AhR↑, 1,   Akt↓, 1,   Akt↑, 3,   Casp3↓, 2,   Casp3∅, 1,   Casp6↓, 1,   Casp9↓, 3,   Casp9∅, 1,   Cyt‑c∅, 1,   iNOS↓, 7,   iNOS↑, 1,   JNK↓, 2,   MAPK↓, 1,   MAPK↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 2,   other↓, 2,   other↑, 1,   other↝, 4,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   PARP∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   ERK↑, 3,   GSK‐3β↓, 1,   Jun↑, 1,   PI3K↓, 1,   PI3K↑, 1,   p‑STAT1↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,  

Migration ⓘ

5LO↓, 1,   MMP2↓, 1,   MMP9↓, 2,   NFAM1↑, 1,   NFAT↑, 2,   PKCδ↑, 1,   TGF-β↑, 2,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,   NO↓, 7,   REL↑, 1,  

Barriers & Transport ⓘ

BBB↑, 6,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 8,   CXCc↑, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL10↑, 3,   IL18↓, 1,   IL1β↓, 15,   IL2↓, 1,   IL2↑, 1,   IL4↑, 1,   IL5↑, 1,   IL6?, 1,   IL6↓, 23,   IL6↑, 3,   IL8↓, 1,   Imm↑, 3,   INF-γ↓, 1,   Inflam↓, 17,   IκB↑, 1,   p‑JAK1↓, 1,   p‑JAK2↓, 1,   LIF↑, 1,   MCP1↓, 3,   MIP2↓, 1,   MyD88↓, 1,   NF-kB↓, 13,   p‑NF-kB↓, 1,   OSM↑, 1,   PGE2↓, 3,   TLR4↓, 3,   TNF-α↓, 21,   TNF-α↑, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 4,   ChAT↑, 2,   tau↓, 1,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   NLRP3↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors ⓘ

ARNT↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 5,   BioAv↝, 6,   Dose↑, 1,   Dose↝, 2,   eff↑, 9,   Half-Life↓, 2,   Half-Life↝, 4,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 2,   creat↓, 2,   GutMicro↑, 3,   IL6?, 1,   IL6↓, 23,   IL6↑, 3,   LDH↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 4,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 6,   hepatoP↑, 4,   memory↑, 4,   neuroP↑, 11,   RenoP↑, 2,   Sleep↑, 1,   Strength↑, 1,   toxicity↓, 3,   toxicity↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 149

Scientific Paper Hit Count for: IL6, Interleukin-6
15 Quercetin
13 Curcumin
13 Hydrogen Gas
12 Lycopene
12 Sulforaphane (mainly Broccoli)
9 Magnetic Fields
8 Propolis -bee glue
8 Resveratrol
8 Silymarin (Milk Thistle) silibinin
8 Shikonin
8 Thymoquinone
7 Baicalein
7 EGCG (Epigallocatechin Gallate)
6 Artemisinin
6 Berberine
6 Boron
6 Rosmarinic acid
6 Urolithin
5 Alpha-Lipoic-Acid
5 Ashwagandha(Withaferin A)
5 Luteolin
4 Silver-NanoParticles
4 Cisplatin
4 Boswellia (frankincense)
4 Piperine
4 Piperlongumine
4 Vitamin C (Ascorbic Acid)
3 Allicin (mainly Garlic)
3 Apigenin (mainly Parsley)
3 Melatonin
3 Butyrate
3 Ellagic acid
3 Fisetin
3 Honokiol
3 Magnetic Field Rotating
3 Pterostilbene
3 Selenite (Sodium)
2 Auranofin
2 Astragalus
2 Ascorbyl Palmitate
2 Astaxanthin
2 Aloe anthraquinones
2 beta-glucans
2 Baicalin
2 Betulinic acid
2 borneol
2 Selenium
2 Caffeic acid
2 Celastrol
2 Chrysin
2 Coenzyme Q10
2 Ursolic acid
2 Paclitaxel
2 Chemotherapy
2 Rutin
2 Selenium NanoParticles
1 2-DeoxyGlucose
1 alpha Linolenic acid
1 Andrographis
1 Atorvastatin
1 immunotherapy
1 Berbamine
1 Biochanin A
1 Bacopa monnieri
1 Bruteridin(bergamot juice)
1 Capsaicin
1 Carnosine
1 Oxygen, Hyperbaric
1 Docosahexaenoic Acid
1 eicosapentaenoic acid
1 diet Short Term Fasting
1 Radiotherapy/Radiation
1 Electrical Pulses
1 Exercise
1 Ferulic acid
1 Garcinol
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 HydroxyCitric Acid
1 Orlistat
1 Juglone
1 Potassium
1 5-fluorouracil
1 Methylsulfonylmethane
1 Naringin
1 Niclosamide (Niclocide)
1 Oleuropein
1 probiotics
1 Bifidobacterium
1 Phosphatidylserine
1 Perilla
1 Docetaxel
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Vitamin B12
1 Folic Acid, Vit B9
1 Vitamin B3,Niacin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:158  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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