5-HETE Cancer Research Results

5-HETE, 5-hydroxyeicosatetraenoic acid: Click to Expand ⟱
Source:
Type:

5-HETE (5-hydroxyeicosatetraenoic acid; primarily 5(S)-HETE) is an arachidonic-acid-derived eicosanoid produced predominantly through the 5-lipoxygenase (ALOX5/5-LOX) pathway, with 5-HPETE serving as an intermediate. 5-HETE functions as a lipid signaling mediator and can be further metabolized to other bioactive products such as 5-oxo-ETE. In several cancer models, increased 5-LOX pathway activity and 5-HETE production can support tumour-cell proliferation, survival and growth-factor signaling; exogenous 5-HETE has directly stimulated lung-cancer-cell growth, whereas inhibition of 5-LOX reduced proliferation and increased programmed cell death. Thus, in cancer contexts where the ALOX5–5-HETE pathway is activated, the typical disease-associated direction is up and the desired anticancer modulation is generally down. 5-HETE also participates in inflammatory lipid signaling and has been reported at increased levels in Alzheimer’s disease-related inflammatory lipid profiles, although its specific contribution to AD is less established than the broader 5-LOX pathway.



Scientific Papers found: Click to Expand⟱
7142- GI,    Phase II study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer
- Trial, Nor, NA
COX2↓, *PGE2↓, *5-HETE↓, *12-HETE↓, *Eic↓, *AntiCan↑, *antiOx↑, *Inflam↓, 5LO↓, eff↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration(tgid=13) ⓘ

5LO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↝, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

12-HETE↓, 1,   5-HETE↓, 1,   Eic↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   PGE2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: 5-HETE, 5-hydroxyeicosatetraenoic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1586  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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