12-HETE Cancer Research Results

12-HETE, 12-hydroxyeicosatetraenoic acid: Click to Expand ⟱
Source:
Type:

12-HETE (12-hydroxyeicosatetraenoic acid; primarily 12(S)-HETE) is an arachidonic-acid-derived eicosanoid produced predominantly through ALOX12/12-lipoxygenase, with 12(S)-HpETE as an intermediate. 12-HETE functions as a bioactive lipid mediator and can signal through receptors including GPR31. In cancer, increased ALOX12–12-HETE signalling can promote tumour-cell migration, epithelial–mesenchymal transition, invasion, angiogenesis and metastatic dissemination, including interactions between platelets and circulating tumour cells. The typical cancer-associated direction is therefore generally up, while the desired anticancer modulation is generally down. 12-HETE also participates in inflammatory and vascular signalling and has been reported as increased in some Alzheimer-related lipidomic models, although its specific causal role in Alzheimer’s disease remains less established.



Scientific Papers found: Click to Expand⟱
7142- GI,    Phase II study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer
- Trial, Nor, NA
COX2↓, *PGE2↓, *5-HETE↓, *12-HETE↓, *Eic↓, *AntiCan↑, *antiOx↑, *Inflam↓, 5LO↓, eff↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration(tgid=13) ⓘ

5LO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↝, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

12-HETE↓, 1,   5-HETE↓, 1,   Eic↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   PGE2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: 12-HETE, 12-hydroxyeicosatetraenoic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1587  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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